Sequential analysis of cadherin expression in a 4-year-old girl with intracranial ependymoma

Yokoi, Kentaro; Akiyama, Masaharu; Yanagisawa, Takaaki; Takahashi‐Fujigasaki, Junko; Yokokawa, Yuichi; Mikami-Terao, Yoko; Fukuoka, Kohei; Fujisawa, Kohji; Nakazaki, Hiromichi; Oi, Shizuo; Eto, Yoshikatsu

doi:10.1007/s00381-006-0197-1

Cited by 4 publications

(3 citation statements)

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“…Decreased expression of N-cadherin has been reported in patients with ependymoma with CSF dissemination. [1213] The ADAMs (A Disintegrin AND Metalloproteinase) are a family of membrane proteins that have potential to be key modulators of cell-matrix interactions through the activities of their constituent domains. ADAMs 8, 12, 19 are significantly upgraded in ependymoma, particularly in the anaplastic variety and are known to be associated with more invasive behavior.…”

Section: Discussionmentioning

confidence: 99%

Fourth ventricular ependymoma with a distant intraventricular metastasis: Report of a rare case

Ambekar

Ranjan

Prasad

et al. 2013

Journal of Neurosciences in Rural Practice

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Ependymoma is one of the uncommon tumors of the central nervous system (CNS) in the adult age group. These tumors have a distinct propensity for metastasis, both within and outside the CNS. However, dissemination at the time of first presentation and retrograde dissemination of the tumor is rare. We report the case of a patient with fourth ventricular anaplastic ependymoma who presented with left lateral ventricular metastasis which was anatomically different from the primary tumor. We describe the clinic-pathological detail of the patient and discuss the probable pathophysiological basis for this rare presentation and its significance in management of the patient.

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Section: Discussionmentioning

confidence: 99%

Fourth ventricular ependymoma with a distant intraventricular metastasis: Report of a rare case

Ambekar

Ranjan

Prasad

et al. 2013

Journal of Neurosciences in Rural Practice

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“…In contrast to meningiomas and pituitary adenomas, the role of classical cadherins in other CNS tumors remains to be clarified, as published data remain limited and conflictive. For instance, leptomeningeal dissemination has been associated with increased N-cadherin expression in medulloblastoma [127], while lower expression levels were identified in disseminated neuroblastoma [95] and ependymoma [128]. Importantly, a recent study showed frequent positivity for N-cadherin in ependymoma and identified increased Ncadherin levels as a predictor of earlier tumor recurrence, arguing a contrary role for N-cadherin as a marker of worse prognosis in ependymoma [129].…”

Section: Meningiomasmentioning

confidence: 99%

Cadherin Expression and EMT: A Focus on Gliomas

et al. 2021

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Cadherins are calcium-binding proteins with a pivotal role in cell adhesion and tissue homeostasis. The cadherin-dependent mechanisms of cell adhesion and migration are exploited by cancer cells, contributing to tumor invasiveness and dissemination. In particular, cadherin switch is a hallmark of epithelial to mesenchymal transition, a complex development process vastly described in the progression of most epithelial cancers. This is characterized by drastic changes in cell polarity, adhesion, and motility, which lead from an E-cadherin positive differentiated epithelial state into a dedifferentiated mesenchymal-like state, prone to metastization and defined by N-cadherin expression. Although vastly explored in epithelial cancers, how these mechanisms contribute to the pathogenesis of other non-epithelial tumor types is poorly understood. Herein, the current knowledge on cadherin expression in normal development in parallel to tumor pathogenesis is reviewed, focusing on epithelial to mesenchymal transition. Emphasis is taken in the unascertained cadherin expression in CNS tumors, particularly in gliomas, where the potential contribution of an epithelial-to-mesenchymal-like process to glioma genesis and how this may be associated with changes in cadherin expression is discussed.

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“…A regulação epigenética através de microRNAs é um mecanismo importante na regulação de TEM de diversos tumores (BULLOCK et al, 2012) ____________________________________________________ 6. Discussão| 87 YOKOI et al, 2007;MOTTA et al, 2008 • Não há diferença estatística entre a expressão dos genes TGF-β1, TGF-β2, SMAD3 e SMAD7 entre as amostras de ependimoma de pacientes pediátricos e amostras de células ependimárias não-neoplásicas;…”

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Investigação do papel da via TGF-β em ependimomas pediátricos

Silva¹

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Investigation of the role of the TGF-β pathway in pediatric ependymomasEpendymoma (EPN) is the third most common brain tumor in pediatric patients, which 90% of cases are located in the intracranial area. The ependymoma originates from the ependymal cells that line the ventricular system and the spinal cord canal and is currently divided into nine molecular subgroups which the supratentorial ependymoma RELA (ST-EPN-RELA) and posterior fossa ependymoma A (PF-EPN-A) presenting the worst prognosis. The prognostic factors for EPN comprise age less or greater than 3 years-old (being less than 3 years-old worse prognosis) and degree of tumor resection. Because it is a highly invasive tumor, with frequent partial resection rate, the vast majority of EPN patients die due to tumor recurrence. The current treatment for EPN consists of surgical resection followed by radiation therapy. The use of chemotherapy has not shown satisfactory results on survival rate of EPN patients. Thus, it is necessary to search for new therapeutic approaches that enable improvement in the survival and quality of life of EPN patients. Some studies have shown that EPN presents alterations in important signaling pathways for several cellular processes, including the TGF-β pathway. The TGF-β signaling pathway acts mainly in the processes of cell migration and invasion in several tumors. Therefore, this study aimed to analyze the role of the TGF-β pathway in EPN aiming at the identification of possible new therapeutic targets based on genes from this signaling pathway. Through the RNAseq, it was possible to identify the enrichment of the TGF-β pathway in the subgroups with tee worst prognosis, ST-EPN-RELA and FP-EPN-A as well as, hub genes that participate or interact with components of the TGF-β pathway. The pharmacological inhibition of the TGF-β pathway with the drug SB431542 in the ependymoma cell line BXD-1425, despite causing a decrease in the gene and protein levels of the SMAD pathway, has not been shown to have an effect on cell viability, apoptosis, migration and cell invasion. However, after 24h of treatment with SB431542, there was a significant increase in cells in the G1 phase and decrease in cells in the S phase of the cell cycle. Hsa-miR-630 regulates several cellular processes, among which migration, cell invasion and epithelial-mesenchymal transition stand out, associated with the regulation of the TGF-β pathway in several tumors. As a possibility to modulate the TGF-β pathway and regulate the processes of migration and cellular invasion of EPN, the BXD-1425 cell line was transduced with the miR-630 hyperexpression lentivirus and its control. The overexpression of miR-630 led to a decrease in cell viability, an increase in the number of cells undergoing apoptosis, a decrease in the rate of migration and cell invasion. In addition, when overexpressing miR-630 there was a decrease in the gene and protein expression of components of the TGF-β/SMAD pathway. These results indicate that miR-630 may be modulating the TGF-β pathway and reg...

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Sequential analysis of cadherin expression in a 4-year-old girl with intracranial ependymoma

Abstract: Decreased expression of N-cadherin may be associated with CSF dissemination and may serve as a useful marker for CSF dissemination in patients with intracranial ependymoma.

Cited by 4 publications

References 11 publications

Fourth ventricular ependymoma with a distant intraventricular metastasis: Report of a rare case

Fourth ventricular ependymoma with a distant intraventricular metastasis: Report of a rare case

Cadherin Expression and EMT: A Focus on Gliomas

Investigação do papel da via TGF-β em ependimomas pediátricos

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Sequential analysis of cadherin expression in a 4-year-old girl with intracranial ependymoma

Abstract: Decreased expression of N-cadherin may be associated with CSF dissemination and may serve as a useful marker for CSF dissemination in patients with intracranial ependymoma.

Cited by 4 publications

References 11 publications

Fourth ventricular ependymoma with a distant intraventricular metastasis: Report of a rare case

Fourth ventricular ependymoma with a distant intraventricular metastasis: Report of a rare case

Cadherin Expression and EMT: A Focus on Gliomas

Investigação do papel da via TGF-&beta; em ependimomas pediátricos

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Investigação do papel da via TGF-β em ependimomas pediátricos