Sequential activation of microcircuits underlying somatosensory-evoked potentials in rat neocortex

Jellema, Tjeerd; Brunia, C.H.M.; Wadman, W.J.

doi:10.1016/j.neuroscience.2004.07.046

Cited by 54 publications

(51 citation statements)

References 34 publications

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“…3 A, B, black CSD traces). This pattern is similar to previously reported findings in the rodent barrel cortex and reflects the propagation of excitatory synaptic activity in the barrel cortical column (Agmon and Connors, 1991;Armstrong-James et al, 1992;Jellema et al, 2004;Lecas, 2004). Stimulation (8 Hz) was followed by a significant increase in the amplitude of several sinks (Fig.…”

Section: Laminar Profile Of 8 Hz Stimulation-induced Plasticitysupporting

confidence: 91%

“…The increased amplitude of the early latency current sink in layer IV of the barrel cortex also suggests that at least part of the potentiation in this system could be located at the thalamocortical synapse or at subcortical synapses. It should be noted here that, because SEP waveforms, particularly laterlatency components, are generated by the combined activity of several neuronal populations (Di et al, 1990;Jellema et al, 2004), waveform plasticity may reflect synaptic plasticity as well as plasticity occurring through other mechanisms, such as changes in neuronal excitability or in the activity of inhibitory interneurons ( Clapp et al, 2006). Interestingly, earlier studies showed that rhythmically patterned bursts of electrical stimulation in thalamic sensory relay nuclei, with frequencies of 5-7 Hz, could induce long-lasting potentiation of cortical responses to natural peripheral or single-pulse thalamic stimulation in the adult rat (Lee and Ebner, 1992;Heynen and Bear, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…1C) (test group, p Ͻ 0.001; control group, p Ͼ 0.928 for effect of recording time on SEP amplitude; repeated-measures ANOVA, n ϭ 5 in each group). This increase was visible already at the earliest poststimulus latencies (Ͻ10 ms poststimulus), where the SEP mostly reflects depolarization of layer IV cortical neurons by thalamocortical afferents from the ventroposteromedial (VPM) thalamic nucleus; it was even clearer between 10 and 30 ms poststimulus, where the SEP reflects disynaptic and plurisynaptic responses in supragranular and infragranular layers of the primary somatosensory cortex (Di et al, 1990;Jellema et al, 2004). SEP potentiation was Figure 1.…”

Section: Long-lasting Frequency-specific Increase Of Somatosensory Rmentioning

confidence: 97%

“…1 A) (Troncoso et al, 2000(Troncoso et al, , 2004. The SEP mainly reflects synchronized postsynaptic events evoked by somatosensory stimuli in populations of cortical neurons; the successive voltage peaks of the SEP waveform (traditionally described by their amplitude and latency) are generated by partly distinct neuronal populations and reflect stages in the processing of sensory information (Allison et al, 1989a,b;Di and Barth, 1991;Peterson et al, 1995;Jellema et al, 2004).…”

Section: Long-lasting Frequency-specific Increase Of Somatosensory Rmentioning

confidence: 99%

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Long-Term Plasticity in Mouse Sensorimotor Circuits after Rhythmic Whisker Stimulation

et al. 2009

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Mice actively explore their environment by rhythmically sweeping their whiskers. As a consequence, neuronal activity in somatosensory pathways is modulated by the frequency of whisker movement. The potential role of rhythmic neuronal activity for the integration and consolidation of sensory signals, however, remains unexplored. Here, we show that a brief period of rhythmic whisker stimulation in anesthetized mice resulted in a frequency-specific long-lasting increase in the amplitude of somatosensory-evoked potentials in the contralateral primary somatosensory (barrel) cortex. Mapping of evoked potentials and intracortical recordings revealed that, in addition to potentiation in layers IV and II/III of the barrel cortex, rhythmic whisker stimulation induced a decrease of somatosensory-evoked responses in the supragranular layers of the motor cortex. To assess whether rhythmic sensory input-based plasticity might arise in natural settings, we exposed mice to environmental enrichment. We found that it resulted in somatosensory-evoked responses of increased amplitude, highlighting the influence of previous sensory experience in shaping sensory responses. Importantly, environmental enrichment-induced plasticity occluded further potentiation by rhythmic stimulation, indicating that both phenomena share common mechanisms. Overall, our results suggest that natural, rhythmic patterns of whisker activity can modify the cerebral processing of sensory information, providing a possible mechanism for learning during sensory perception.

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Section: Laminar Profile Of 8 Hz Stimulation-induced Plasticitysupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Long-lasting Frequency-specific Increase Of Somatosensory Rmentioning

confidence: 97%

Section: Long-lasting Frequency-specific Increase Of Somatosensory Rmentioning

confidence: 99%

See 2 more Smart Citations

Long-Term Plasticity in Mouse Sensorimotor Circuits after Rhythmic Whisker Stimulation

et al. 2009

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“…One hundred stimuli were averaged per waveform at each of the 3 stimulus intensities. The peak latencies and amplitudes of the P1 and N1 parameters of the SSEP waveform, the primary evoked cortical field potential (Jellema et al, 2004), after 1.5mA stimulus onset were measured (Fig. 1).…”

Section: Ssepsmentioning

confidence: 99%

Loss and spontaneous recovery of forelimb evoked potentials in both the adult rat cuneate nucleus and somatosensory cortex following contusive cervical spinal cord injury

Onifer

Nunn

Decker

et al. 2007

Experimental Neurology

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Varying degrees of neurologic function spontaneously recovers in humans and animals during the days and months after spinal cord injury (SCI). For example, abolished upper limb somatosensory potentials (SSEPS) and cutaneous sensations can recover in persons post-contusive cervical SCI. To maximize recovery and the development/evaluation of repair strategies, a better understanding of the anatomical locations and physiological processes underlying spontaneous recovery after SCI is needed. As an initial step, the present study examined whether recovery of upper limb SSEPs after contusive cervical SCI was due to the integrity of some spared dorsal column primary afferents that terminate within the cuneate nucleus and not one of several alternate routes. C5-C6 contusions were performed on male adult rats. Electrophysiological techniques were used in the same rat to determine forelimb evoked neuronal responses in both cortex (SSEPS) and the cuneate nucleus (terminal extracellular recordings). SSEPs were not evoked 2 days post-SCI but were found at 7 days and beyond, with an observed change in latencies between 7 and 14 days (suggestive of spared axon remyelination). Forelimb evoked activity in the cuneate nucleus at 15 but not 3 days post-injury occurred despite dorsal column damage throughout the cervical injury (as seen histologically). Neuroanatomical tracing (using 1% unconjugated cholera toxin B subunit) confirmed that upper limb primary afferent terminals remained within the cuneate nuclei. Taken together, these results indicate Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access

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Layer IV of the primary somatosensory cortex has the highest complexity under anesthesia and cortical complexity is modulated by specific thalamic inputs

et al. 2006

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Sequential activation of microcircuits underlying somatosensory-evoked potentials in rat neocortex

Cited by 54 publications

References 34 publications

Long-Term Plasticity in Mouse Sensorimotor Circuits after Rhythmic Whisker Stimulation

Long-Term Plasticity in Mouse Sensorimotor Circuits after Rhythmic Whisker Stimulation

Loss and spontaneous recovery of forelimb evoked potentials in both the adult rat cuneate nucleus and somatosensory cortex following contusive cervical spinal cord injury

Layer IV of the primary somatosensory cortex has the highest complexity under anesthesia and cortical complexity is modulated by specific thalamic inputs

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