Sequential Activation of CD8+ T Cells in the Draining Lymph Nodes in Response to Pulmonary Virus Infection

Yoon, Heesik; Legge, Kevin L.; Sung, Sun-sang J.; Braciale, Thomas J.

doi:10.4049/jimmunol.179.1.391

Cited by 47 publications

(57 citation statements)

References 42 publications

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“…Using i.n. CFSE administration, we demonstrated that this rapid augmentation of DC migration into the LN is transient, however, peaking within 18 h post infection and returning to baseline levels by 48 h post infection [65,129]. Contrasting reports have demonstrated a slightly longer period of enhanced DC migration from the lungs to the LN, sometimes as long as 5-7 days post infection [122,125], suggesting that the period of enhanced migration may be dependent upon the strain of IAV and the dose of infection.…”

Section: Migration From the Lungs To The Lnmentioning

confidence: 93%

Innate immune control and regulation of influenza virus infections

McGill

Heusel

Legge

2009

Journal of Leukocyte Biology

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145

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Adaptive immune responses are critical for the control and clearance of influenza A virus (IAV) infection. However, in recent years, it has become increasingly apparent that innate immune cells, including natural killer cells, alveolar macrophages (aMphi), and dendritic cells (DC) are essential following IAV infection in the direct control of viral replication or in the induction and regulation of virus-specific adaptive immune responses. This review will discuss the role of these innate immune cells following IAV infection, with a particular focus on DC and their ability to induce and regulate the adaptive IAV-specific immune response.

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Section: Migration From the Lungs To The Lnmentioning

confidence: 93%

Innate immune control and regulation of influenza virus infections

McGill

Heusel

Legge

2009

Journal of Leukocyte Biology

Self Cite

145

150

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“…This process is tightly regulated in a spatiotemporal manner. Although naive T cells are constantly trafficking through the MLNs, only those that have arrived within a limited time window were able to differentiate into effector cells (39). Activated NK cells were required to promote optimal recruitment of both DC and T cells into the pMLN.…”

Section: Discussionmentioning

confidence: 99%

NK Cells Regulate CD8+ T Cell Priming and Dendritic Cell Migration during Influenza A Infection by IFN-γ and Perforin-Dependent Mechanisms

Tang

et al. 2012

The Journal of Immunology

102

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An effective immune response against influenza A infection depends on the generation of virus-specific T cells. NK cells are one of the first-line defenses against influenza A infection. We set out to delineate the role of NK cells in T cell immunity using a murine model of influenza A infection with A/PR/8/34. We show that early T cell recruitment mainly occurs in the posterior mediastinal lymph node (pMLN). Depletion of NK cells significantly impaired both dendritic cell (DC) and T cell recruitment into the pMLN. A similar reduction of T cell recruitment was observed when migration was blocked by pertussis toxin, suggesting that migration of pulmonary NK cells and DCs regulates cell recruitment to the pMLN. T cell recruitment was dependent on IFN-γ, and transfer of IFN-γ–competent naive NK cells into IFN-γ−/− mice restored T cell recruitment, whereas IFN-γ–deficient NK cells failed to do so. In addition, NK cell depletion reduced the uptake and transport of influenza A virus by DCs, and significantly impaired the virus-specific T cell response. Both IFN-γ−/− and perforin−/− mice showed reduced viral Ag transport by DCs, suggesting that the ability of NK cells to influence virus transport depends on IFN-γ and perforin. In summary, our data suggest that NK cells play a critical role in the initiation and shaping of the T cell response after influenza A infection.

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“…The kinetics of T cell activation following intranasal (i.n.) influenza A virus infection depends upon the strain of virus used and the time it takes to reach the peak viral load in the lungs (8). Ag presentation to CD8 T cells after influenza A virus infection has not been assessed directly but rather inferred indirectly from in vitro studies suggesting that draining lymph nodes are the site of T cell activation (7,9).…”

mentioning

confidence: 99%

Cutting Edge: Antigen Presentation to CD8 T Cells after Influenza A Virus Infection

Ingulli

Funatake

Jacovetty

et al. 2009

The Journal of Immunology

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Influenza A virus infection induces massive inflammation and lung damage. Activation of CD8 T cells by dendritic cells (DCs) is necessary to control disease. We undertook studies to track directly Ag presentation to CD8 T cells in vivo through the first 72 h after infection with OVA-expressing influenza A virus. We found that Ag presentation by DCs occurs strictly in the draining lymph nodes and not within the lung itself. Surprisingly, Ag presentation was found to be mediated by a CD11b+ DC population. Finally, the expression of antigenic complexes on DCs correlated with the location and timing of CD8 T cell activation. These results have implications for approaches to control influenza A virus infection.

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Sequential Activation of CD8+ T Cells in the Draining Lymph Nodes in Response to Pulmonary Virus Infection

Cited by 47 publications

References 42 publications

Innate immune control and regulation of influenza virus infections

Innate immune control and regulation of influenza virus infections

NK Cells Regulate CD8+ T Cell Priming and Dendritic Cell Migration during Influenza A Infection by IFN-γ and Perforin-Dependent Mechanisms

Cutting Edge: Antigen Presentation to CD8 T Cells after Influenza A Virus Infection

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