Sequencing of 15 new BoLA‐DRB3 alleles

Abstract

The class II DR of bovine major histocompatibility complex of cattle (BoLA) plays a central role in the regulation of the immune response through their ability to present those peptides to T-cell receptors. In this work, we sequenced the exon2 of DRB3 to identify new alleles in Chinese yellow cattle, a total of 15 new BoLA-DRB3 alleles were found.

Genetic diversity and population genetic analysis of bovine MHC class II DRB3.2 locus in three Bos indicus cattle breeds of Southern India

“…The concluded nucleotide and translated amino acid sequences of the two newly identified BoLA‐DRB3.2 PCR‐RFLP alleles were compared with sequences in NCBI GenBank and EMBL cattle IPD‐MHC database (http://www.ebi.ac.uk/cgi-bin/ipd/mhc/view_nomenclature.cgi?bola.drb3). The comparative sequence analysis revealed that the BoLA‐DRB3.2 PCR‐RFLP allele DRB3.2*a′aa had absolute sequence similarity with previously reported BoLA‐DRB3.2 allele DRB3*5702 assigned NCBI GenBank ID: , observed in Chinese yellow cattle (Wang et al. , 2008) (Fig.…”

Major Histocompatibility Complex Class II (DRB3) Genetic Diversity in Spanish Morucha and Colombian Normande Cattle Compared to Taurine and Zebu Populations

“…Different BoLA-DRB3 alleles have been associated with variations in susceptibility to infectious diseases (Dietz et al, 1997;Acosta-Rodriguez et al, 2005;Martinez et al, 2006;Nascimento et al, 2006;Kulberg et al, 2007;Juliarena et al, 2008;Nikbakht et al, 2016;Carignano et al, 2017), vaccine responses (Garcia-Briones et al, 2000;Rupp et al, 2007;Baxter et al, 2009;Gowane et al, 2013) and production traits (Sharif et al, 1999). BoLA-DRB3 genetic diversity has been characterized in both widespread and autochthonous creole cattle breeds (Takeshima et al, 2001;Takeshima et al, 2002;Takeshima et al, 2003;Baxter et al, 2008;Wang et al, 2008;Giovambattista et al, 2013;Takeshima et al, 2014;Takeshima et al, 2015a).…”

The Major Histocompatibility Complex in Bovines: A Review

“… n a -Total number of alleles in the breed studied, n a a number of alleles with frequency higher than 0.05 N -Total number of animals studied, b Sharif et al [108], c Dietz et al [109], d Dietz et al [110], e Gilliespie et al [111], f Ripoli et al [112], g Giovambattista et al [113], h Takeshima et al [114], i Udina et al [115], j Nassiry et al [116], k Mosafer and Nassiry [117], l Kulberg et al [118], m Behl et al [119], n Behl et al [120], o Behl et al [121], p Pashmi et al [122], q Wang et al [123], r Mohammadi et al [124], s Yoshida et al [125], t Miyasaka et al [126]. …”