Sequencing and characterization of Varicella-Zoster virus vaccine strain SuduVax

Kim, Jong Ik; Jung, Gyoo Seung; Kim, Yu Young; Ji, Ga Young; Kim, Hyung Seok; Wang, Wen Dan; Park, Ho Sun; Park, Song Yong; Kim, Geun Hee; Kwon, Shi Nae; Lee, Keon Myung; Ahn, Jinhee; Yoon, Yeup; Lee, Chan Hee

doi:10.1186/1743-422x-8-547

Cited by 24 publications

(25 citation statements)

References 21 publications

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“…Hence, the right method of education with an opportunity to practice and apply what has been taught is essential. Nursing teachers should emphasize on prevention and management of Chickenpox [35][36][37].…”

Section: Nursing Educationmentioning

confidence: 99%

An Evaluation to assess the Knowledge regarding Prevention and Management of Chickenpox in Children among Mothers having Children below 10 years of age residing at selected community area of Allahabad (India)

Joseph

Mathew

2013

IJANS

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Chickenpox is a worldwide disease and is no respecter race or class. The incidence increases in spring & winter months in the temperate zones. In the tropics, the peak incidence is during winter and early spring. The disease in fact started spreading from February itself. Lack of knowledge among common people on preventing water contamination is helping the virus to spread rapidly. The descriptive study attempts to assess the knowledge regarding prevention and management of chickenpox among mothers of below 10 years of age children who are residing at Naini, Allahabad with a view to develop an information booklet. Method: The study involved single group test without a control, using nonexperimental descriptive design, with non-probability convenient sampling. 60 women were involved in data collection by using structured questionnaire. The study came to an end by implementation of information booklet on chickenpox and its prevention and management, and the results were described using descriptive and inferential statistics. Results: The overall mean knowledge score was found to be 48.86 % and S.D 5.87. The highest mean knowledge score was found on general health (46.5%). The mean knowledge score varied from 46.5% to 55.6% on different aspects of chickenpox. Chi-square test implies that there was a statistically significant association between selected demographic variables with knowledge of prevention and home care management of chickenpox at 5 percent level. Conclusion: The overall findings of the study clearly showed that there is lack of knowledge of prevention and home care management of chickenpox among mothers and the results revealed that distribution of information booklet on chickenpox and its prevention and management will be helpful for the women to gain knowledge.

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Section: Nursing Educationmentioning

confidence: 99%

An Evaluation to assess the Knowledge regarding Prevention and Management of Chickenpox in Children among Mothers having Children below 10 years of age residing at selected community area of Allahabad (India)

Joseph

Mathew

2013

IJANS

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“…The above claim is bolstered by the recent publication of a third unrelated VZV sequence. In a completely independent pharmaceutical endeavor, a second live attenuated varicella vaccine called Suduvax has been produced and distributed to children in South Korea since 1994 (18). As with vOka, the South Korean vaccine product was created after serial passaging of a wild-type Korean VZV strain in cultured cells.…”

Section: Discussionmentioning

confidence: 99%

The Attenuated Genotype of Varicella-Zoster Virus Includes an ORF0 Transitional Stop Codon Mutation

Peters

Tyler

Carpenter

et al. 2012

J Virol

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Varicella-zoster virus (VZV) is the first of the human herpesviruses to be attenuated and subsequently approved as a live vaccine to prevent varicella and herpes zoster. Both the attenuated VZV vaccine, called vaccine Oka or vOka, and the parental strain pOka have been completely sequenced. Yet the specific determinants of attenuation are uncertain. The open reading frame (ORF) with the most single nucleotide polymorphisms (SNPs), ORF62, encodes the regulatory protein IE62, but IE62 studies have failed to define a specific SNP associated with attenuation. We have completed next-generation sequencing of the VZV Ellen genome, a strain known to be highly attenuated by its very limited replication in human skin xenografts in the SCID mouse model of VZV pathogenesis. A comparative analysis of the Ellen sequence with all other complete VZV sequences was extremely informative. In particular, an unexpected finding was a stop codon mutation in Ellen ORF0 (herpes simplex virus UL56 homolog) identical to one found in vOka, combined with the absence of polymorphisms in most Ellen ORFs that were known to be mutated in vOka. The mutated ORF0 protein was also imaged in both two dimensions and three dimensions by confocal microscopy. The probability of two VZV strains not connected by a recent common ancestor having an identical ORF0 SNP by chance would be 1 × 10 −8 , in other words, extremely unlikely. Taken together, these bioinformatics analyses strongly suggest that the stop codon ORF0 SNP is one of the determinants of the attenuation genotype of live VZV vaccines.

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“…A varicella vaccine containing live-attenuated VZV (named Oka strain) was developed in Japan in the early 1970s 4 . Several licensed varicella vaccines are available, all using live-attenuated VZV and all based on the Oka strain except the vaccine developed in South Korea 5 . The vaccine is available as a single-antigen vaccine or in combination with measles, mumps, and rubella (MMRV).…”

Section: Introductionmentioning

confidence: 99%

Severe varicella in persons vaccinated with varicella vaccine (breakthrough varicella): a systematic literature review

Leung

Broder

Marin

2017

Expert Review of Vaccines

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INTRODUCTION Varicella vaccines are highly effective at preventing disease, but varicella may occur among vaccinated persons (termed breakthrough varicella). Breakthrough varicella is generally mild, but severe cases have been reported. The objective of this review is to describe severe breakthrough varicella. AREAS COVERED We conducted a systematic review of articles published during 1974–2016. A total of 34 articles were included in our review: 21 described breakthrough varicella with disseminated varicella-zoster virus (VZV) infection with other organ involvement in addition to skin (none among two-dose vaccinees); 9 described hospitalized breakthrough varicella without mention of other organ involvement in addition to skin (of which 2 reported 4 two-dose vaccinees); and 4 described both. A total of 52–60 unique breakthrough varicella cases with disseminated VZV infection with other organ involvement in addition to skin reported with the following complications, not mutually exclusive: pneumonia (n=8–9 cases), neurologic (n=18–24 cases), hematologic (n=10–11 cases), ocular (n=5 cases), renal (n=2 cases), hepatic (n=3 cases), secondary infection with bacteremia or sepsis (n=8 cases), and other complication (n=4 cases). There were 6 cases of fatal breakthrough varicella. EXPERT COMMENTARY With >31 million doses distributed annually worldwide since 2007, severe breakthrough varicella can occur but they appear to be uncommon.

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Sequencing and characterization of Varicella-Zoster virus vaccine strain SuduVax

Cited by 24 publications

References 21 publications

An Evaluation to assess the Knowledge regarding Prevention and Management of Chickenpox in Children among Mothers having Children below 10 years of age residing at selected community area of Allahabad (India)

An Evaluation to assess the Knowledge regarding Prevention and Management of Chickenpox in Children among Mothers having Children below 10 years of age residing at selected community area of Allahabad (India)

The Attenuated Genotype of Varicella-Zoster Virus Includes an ORF0 Transitional Stop Codon Mutation

Severe varicella in persons vaccinated with varicella vaccine (breakthrough varicella): a systematic literature review

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