Sequencing and analysis of the complete mitochondrial genome of <i>Coenobita brevimanus</i>

Wang, Qi; Li, Yunjie; Tang, Dan; Wang, Jie; Xu, Jiayan; Xu, Xinyi; Wang, Zhengfei

doi:10.1080/23802359.2019.1643801

Cited by 7 publications

(5 citation statements)

References 9 publications

(10 reference statements)

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“…Anomura was divided into two main branches in our phylogenetic tree, which was identi ed with the previous researches [35,51] Consistent with the traditional morphological classi cation, the phylogenetic analyses based on molecular methods showed that D. Edwardsii was clustered rstly clustered with the Diogenidae species Clibanarius infraspinatus and then clustered with another Diogenidae species Dardanus arrosor. As reported, Clibanarius infraspinatus possesses a favor of codon TAT(Ser) and owns a highest Ser content in amino acid composition [40], which showed the same pattern with D. Edwardsii.…”

Section: Phylogenetic Relationshipssupporting

confidence: 82%

“…For the D. Edwardsii mitogenome, the AT skew is -0.110, and the GC skew is 0.233, which indicates bias toward T and G. This asymmetry often occurs on Anomura species [11,[33][34][35]. In mammals, the duration of single-stranded state of the "heavy-stranded" genes during mitochondrial DNA replication can explain this asymmetry [36].…”

Section: Edwardsii Mitogenome Organizationmentioning

confidence: 99%

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The complete mitochondrial genome of the hermit crab Diogenes Edwardsii (Anomura: Diogenidae) and phylogenetic relationships within infraorder Anomura

Pang

Feng

et al. 2022

Preprint

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Complete mitochondrial genome (mitogenome) can provide important information for gene rearrangement, molecular evolution and phylogenetic analysis. Currently, only a few mitogenomes of Paguridae in the infraorder Anomura have been reported. This study reports the first complete mitogenome of the hermit crab Diogenes Edwardsii assembled using high-throughput sequencing. The mitogenome of D. Edwardsii is 19,858 bp in length and comprises 13 protein-coding genes, 2 ribosomal RNA genes, and 22 transfer RNA genes. There are 28 and 6 genes observed on the heavy and light strands, respectively. The genome composition was highly A + T biased (72.16%), and exhibited a negative AT-skew (-0.110) and positive GC-skew (0.233). The D. Edwardsii mitogenome possessed distinctive gene arrangements compared with the reported mitogenomes of the species in the same family. Phylogenetic analyses based on the nucleotide dataset of 16 Anomura species indicated that D. Edwardsii was closely related to Clibanarius infraspinatus. Positive selection analysis showed that two residues located in cox1 and cox2 were identified as positively selected sites with high BEB value (> 95%), indicating that these two genes are under positive selection pressure. This finding helps to better understand the gene rearrangements and the evolutionary status of D. Edwardsii, and provide data for further phylogenetic study of Anomura.

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Section: Phylogenetic Relationshipssupporting

confidence: 82%

Section: Edwardsii Mitogenome Organizationmentioning

confidence: 99%

The complete mitochondrial genome of the hermit crab Diogenes Edwardsii (Anomura: Diogenidae) and phylogenetic relationships within infraorder Anomura

Pang

Feng

et al. 2022

Preprint

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“…Notably, it substantially improves patient survival rates and overall outcomes. Concurrent lapatinib administration in clinical trials has consistently resulted in substantially prolonged survival without progression and overall survival incidences than separate agents for chemotherapy [15]. It highlights lapatinib's significance in such treatment.…”

Section: Applications Of Lapatinib In Breast Cancer Treatmentmentioning

confidence: 93%

The mechanism of lapatinib and its application in breast cancer

Wang

2023

TNS

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This paper aims to study the synthetic route, mechanism of action and application of lapatinib in breast cancer. As a common malignant tumor, breast cancer poses a serious threat to the life and health of patients. As an effective targeted drug, lapatinib is significant in treating breast cancer. Its pharmacological effects can block the growth and metastasis of tumor cells by inhibiting specific signaling pathways and affect cancer cells metabolism and drug efficacy. Its molecular mechanism is mainly through targeting the epidermal growth factor receptor (EGFR) to inhibit the proliferation and survival of tumor cells. Studies on lapatinibs drug metabolism and pharmacodynamics also described its metabolism and therapeutic effect in vivo. Secondly, the pathophysiology of breast cancer was summarized, including the pathogenesis, clinical manifestations, and molecular biological characteristics of breast cancer. The therapeutic effect, application, efficacy evaluation, and adverse reaction management of lapatinib were analyzed for the application of lapatinib in the treatment of breast cancer. Moreover, the existing lapatinib synthetic routes were described. Lapatinib has a substantial treatment influence and may effectively decrease harmful reactions when used to treat breast cancer. Nevertheless, additional study is required to ascertain its optimal application and possible mechanism of action in breast cancer treatment.

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“…Additional references were cited within the Supporting Information. [24][25][26][27][28][29][30][31][32][33][34][35][36]…”

Section: Supporting Informationmentioning

confidence: 99%

“…[20][21][22] Based on recent reports describing the utilization of (S(e)CN) 2 for electrophilic S(e)CN-transfer reactions, [20,21] we thus rationalize that these species are formed in situ under our reaction conditions and that they are acting as the relevant electrophilic S(e)CN-transfer reagents with different pronucleophiles. To substantiate this proposal, we synthesized selenocyanogen ((SeCN) 2 ) using a slightly adopted literature procedure 24 and reacted it with 1 a, which delivered product 3 a in comparable yield to our oxidative procedure (Scheme 2). Furthermore, MS analyses of mixtures of KSeCN or NaSCN and DBPO revealed the in situ formation of S(e)(CN) 2 and (S(e)CN) 2 (analogous NMR experiments did not allow us to detect these species directly but we only observed benzoic acid, which a) underscores the rapid reaction between DBPO and the used nucleophilic S(e)CN salts and b) the high reactivity and sensitivity of the hereby formed electrophilic species).…”

mentioning

confidence: 98%

Dibenzoylperoxide‐Mediated Oxidative α‐Thio/Seleno‐Cyanation of β‐Ketoesters and Oxindoles

Mairhofer,

Röser,

Aryafard

et al. 2023

Eur J Org Chem

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We herein report a protocol for the α‐thio‐ and α‐seleno‐cyanation of different cyclic β‐ketoesters and oxindoles by using NaSCN or KSeCN as easily accessible inorganic nucleophilic S(e)CN sources under oxidative conditions. Key to success for both transformations is the use of dibenzoylperoxide as an oxidant allowing for the coupling of two inherently nucleophilic species under operationally simple conditions in high yields and with broad functional group tolerance.

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Sequencing and analysis of the complete mitochondrial genome of Coenobita brevimanus

Cited by 7 publications

References 9 publications

The complete mitochondrial genome of the hermit crab Diogenes Edwardsii (Anomura: Diogenidae) and phylogenetic relationships within infraorder Anomura

The complete mitochondrial genome of the hermit crab Diogenes Edwardsii (Anomura: Diogenidae) and phylogenetic relationships within infraorder Anomura

The mechanism of lapatinib and its application in breast cancer

Dibenzoylperoxide‐Mediated Oxidative α‐Thio/Seleno‐Cyanation of β‐Ketoesters and Oxindoles

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