Sequenceserver: a modern graphical user interface for custom BLAST databases

Abstract

28The dramatic drop in DNA sequencing costs has created many opportunities for novel biological research. These 29 opportunities largely rest upon the ability to effectively compare newly obtained and previously known sequences. 30This is commonly done with BLAST, yet using BLAST directly on new datasets requires substantial technical skills or 31 helpful colleagues. Furthermore, graphical interfaces for BLAST are challenging to install and largely mimic underlying 32 computational processes rather than work patterns of researchers. 33We combined a user-centric design philosophy with sustainable software development approaches to create Se-34 quenceserver (http://sequenceserver.com), a modern graphical user interface for BLAST. Sequenceserver sub-35 stantially increases the efficiency of researchers working with sequence data. This is due to innovations at three 36 levels. First, our software can be installed and used on custom datasets extremely rapidly for personal and shared

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3D sorghum reconstructions from depth images identify QTL regulating shoot architecture

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