Sequence Variants ofADIPOQand Association with Type 2 Diabetes Mellitus in Taiwan Chinese Han Population

Abstract

Diabetes is a serious global health problem. Large-scale genome-wide association studies identified loci for type 2 diabetes mellitus (T2DM), including adiponectin (ADIPOQ) gene and transcription factor 7-like 2 (TCF7L2), but few studies clarified the effect of genetic polymorphisms of ADIPOQ and TCF7L2 on risk of T2DM. We attempted to elucidate association between T2DM and polymorphic variations of both in Taiwan's Chinese Han population, with our retrospective case-control study genotyping single nucleotide polymorphisms (SNPs) in ADIPOQ and TCF7L2 genes both in 149 T2DM patients and in 139 healthy controls from Taiwan. Statistical analysis gauged association of these polymorphisms with risk of T2DM to show ADIPOQ rs1501299 polymorphism variations strongly correlated with T2DM risk (P = 0.042), with rs2241766 polymorphism being not associated with T2DM (P = 0.967). However, both polymorphisms rs7903146 and rs12255372 of TCF7L2 were rarely detected in Taiwanese people. This study avers that ADIPOQ rs1501299 polymorphism contributes to risk of T2DM in the Taiwanese population.

ADIPOQ,KCNJ11 and TCF7L2 polymorphisms in type 2 diabetes in Kyrgyz population: A case‐control study

“…KCNJ11 gene Glu23Lys polymorphic marker's association with T2D is likely associated with the replacement of glutamate with lysine in the 23rd position of Kir 6.2 protein, which results in suppressed insulin blood secretion as a result of increased ATP‐dependent ionic channel activity, membrane potential change and intracellular calcium concentration decrease, which initiates insulin secretion . The association of ADIPOQ gene G276T polymorphic locus with T2D in our study was also previously confirmed in the Japanese and Taiwanese, and such association may be explained with impaired tissue susceptibility to insulin …”

“…Genetic predisposition to T2D was studied widely during the last decades . At present, around 50 candidate genes are considered to increase the likelihood of T2D, of which adiponectin gene ( ADIPOQ ), potassium channel, inwardly rectifying subfamily J, member 11 ( KCNJ11 ) and transcription factor 7‐like 2 ( TCF7L2 [IVS3C>T]) may be associated with insulin resistance and β‐cells dysfunction . Carriage of various SNP combinations may explain clinical heterogeneity of this disease.…”

“…[2][3][4] At present, around 50 candidate genes are considered to increase the likelihood of T2D, of which adiponectin gene (ADIPOQ), potassium channel, inwardly rectifying subfamily J, member 11 (KCNJ11) and transcription factor 7-like 2 (TCF7L2 [IVS3C>T]) may be associated with insulin resistance and β-cells dysfunction. [5][6][7][8][9][10][11][12][13] Carriage of various SNP combinations may explain clinical heterogeneity of this disease. Therefore, the analysis of cumulative SNP contribution in T2D is important.…”

Adiponectin Genotype, Blood Pressures, and Arterial Stiffness: The Cardiometabolic Risk in Chinese (CRC) Study

“…Recent genome‐wide association studies identified genetic variants in the adiponectin gene ( ADIPOQ ) associated with blood levels of adiponectin . The ADIPOQ variants have also been related to other metabolic disorders such as diabetes and insulin resistance . Among these genetic variants, one SNP rs864265, located 5 kb upstream of the widely discussed ADIPOQ promoter region and 16 kb upstream of the translation start site (chr3: 188 036 986), showed the strongest association with plasma adiponectin, also associated with insulin resistance and diabetes‐related metabolic traits .…”

“…[8][9][10][11][12] The ADIPOQ variants have also been related to other metabolic disorders such as diabetes and insulin resistance. [13][14][15] Among these genetic variants, one SNP rs864265, located 5 kb upstream of the widely discussed ADIPOQ promoter region and 16 kb upstream of the translation start site (chr3: 188 036 986), showed the strongest association with plasma adiponectin, also associated with insulin resistance and diabetes-related metabolic traits. 11,12 However, data are scarce on the relationship between ADIPOQ variants and markers of early-stage atherosclerosis.…”