Sequence-Specific Molecular Lithography on Single DNA Molecules

Keren, Kinneret; Krueger, Michael; Gilad, Rachel; Ben-Yoseph, Gdalyahu; Sivan, Uri; Braun, Erez

doi:10.1126/science.1071247

Cited by 586 publications

(420 citation statements)

References 18 publications

Supporting

Mentioning

405

Contrasting

Unclassified

Order By: Relevance

“…As a result, some approaches have combined DNA and proteins to create functional nanomaterials. 14 In contrast, peptides and proteins are built from 20 proteinogenic plus a wide variety of non-natural amino-acids. This degeneracy leads to chemical diversity, evident by the display of aliphatic, acidic, basic, or aromatic side chains from a peptide backbone, and structural complexity, manifested by the multitude of possible molecular architectures like helices, β-sheets, and tubules.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled collagen-like peptide fibers as templates for metallic nanowires

et al. 2008

View full text Add to dashboard Cite

Inspired by nature's ability to fabricate supramolecular nanostructures from the bottom-up, materials scientist have become increasingly interested in the use of biomolecules like DNA, peptides, or proteins as templates for the creation of novel nanostructures and nanomaterials. Although the advantages of self-assembling biomolecular structures clearly lie in their chemical diversity, spatial control, and numerous geometric architectures, it is challenging to elaborate them into functional hybrid inorganic-bionanomaterials without rendering the biomolecular scaffold damaged or dysfunctional. In this study, attachment of gold nanoparticles to collagen-related self-assembling peptides at L-lysine residues incorportated within the peptides sequence and the N-terminus led to metal nanoparticle-decorated fibers. After electroless silver plating, these fibers were completely metalized, creating electrically conductive nanowires under mild conditions while leaving the peptide fiber core intact. This study demonstrates the bottom-up assembly of synthetic peptidic fibers under mild conditions and their potential as templates for other complex inorganic-organic hybrid nanostructures.

show abstract

Section: Introductionmentioning

confidence: 99%

Self-assembled collagen-like peptide fibers as templates for metallic nanowires

et al. 2008

View full text Add to dashboard Cite

show abstract

“…For example, Keren et al showed that sequence-specific molecular lithography is possible; they used proteins that bind to specific sites on DNA to create patterns of metal coatings on single molecules of DNA. 8 The objective of this work is to demonstrate that DNA also satisfies the other two requirements for a template. We do so by stretching and orienting individual DNA molecules in microscopic channels.…”

mentioning

confidence: 99%

Combing of Molecules in Microchannels (COMMIC): A Method for Micropatterning and Orienting Stretched Molecules of DNA on a Surface

Petit

Carbeck

2003

Nano Lett.

View full text Add to dashboard Cite

This paper presents a new method for creating microscopic patterns of stretched and oriented molecules of DNA on a surface. Combing of molecules in microchannels (COMMIC), a process by which molecules are deposited and stretched onto a surface by the passage of an air−water interface, creates these patterns. This approach demonstrates that the direction of stretching of the molecules is always perpendicular to the air−water interface; the shape and motion of this interface serve as an effective local field directing the chains dynamically as they are stretched onto the surface. The geometry of the microchannel directs the placement of the DNA molecules, while the geometry of the air− water interface directs the local orientation and curvature of the molecules. This ability to control both the placement and orientation of chains has implication for the use of COMMIC in genetic analysis and in the bottom-up approach to nanofabrication.

show abstract

“…However, the transfer of spatial information to other 2D materials remains unexplored. Metallization produces nanowires and particles composed of disconnected grains, which decrease the conductivity [34][35][36][37][38][39][40] . In this way, DNA metallization is limited in its ability to construct nanoelectronic devices 40 .…”

mentioning

confidence: 99%

“…DNA nanostructures can be used to expand the morphological and functional diversity of other nanomaterials. For example, DNA nanostructures can template the positioning of nanoparticles and carbon nanotubes [29][30][31][32][33] and they can also be functionalized into metallic nanostructures [34][35][36][37][38][39][40] . However, the transfer of spatial information to other 2D materials remains unexplored.…”

mentioning

confidence: 99%

Metallized DNA nanolithography for encoding and transferring spatial information for graphene patterning

et al. 2013

View full text Add to dashboard Cite

The vision for graphene and other two-dimensional electronics is the direct production of nanoelectronic circuits and barrier materials from a single precursor sheet. DNA origami and single-stranded tiles are powerful methods to encode complex shapes within a DNA sequence, but their translation to patterning other nanomaterials has been limited. Here we develop a metallized DNA nanolithography that allows transfer of spatial information to pattern two-dimensional nanomaterials capable of plasma etching. Width, orientation and curvature can be programmed by specific sequence design and transferred, as we demonstrate for graphene. Spatial resolution is limited by distortion of the DNA template upon Au metallization and subsequent etching. The metallized DNA mask allows for plasmonic enhanced Raman spectroscopy of the underlying graphene, providing information on defects, doping and lattice symmetry. This DNA nanolithography enables wafer-scale patterning of two-dimensional electronic materials to create diverse circuit elements, including nanorings, three-and four-membered nanojunctions, and extended nanoribbons.

show abstract

Sequence-Specific Molecular Lithography on Single DNA Molecules

Cited by 586 publications

References 18 publications

Self-assembled collagen-like peptide fibers as templates for metallic nanowires

Self-assembled collagen-like peptide fibers as templates for metallic nanowires

Combing of Molecules in Microchannels (COMMIC): A Method for Micropatterning and Orienting Stretched Molecules of DNA on a Surface

Metallized DNA nanolithography for encoding and transferring spatial information for graphene patterning

Contact Info

Product

Resources

About