Sequence of improvement in depressive symptoms across cognitive therapy and pharmacotherapy

Bhar, Sunil; Gelfand, Lois A.; Schmid, Sabine; Gallop, Robert; DeRubeis, Robert J.; Hollon, Steven D.; Amsterdam, Jay D.; Shelton, Richard C.; Beck, Aaron T.

doi:10.1016/j.jad.2007.12.227

Cited by 26 publications

(24 citation statements)

References 19 publications

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“…At the end of the 16-week treatment phase of the study, there were no differences in outcome between ADM and CT, with 58% of patients in both treatment groups meeting the criteria for ‘response’. Curiously, there was no indication that the two treatments affected different symptom clusters of depression: patients treated with either ADM or CT showed comparable rates of change of both cognitive and vegetative symptoms of depression 36. This contrasts with results from studies that compared ADM with other psychosocial interventions.…”

Section: Outcomes Of Ct Versus Admmentioning

confidence: 81%

Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms

Siegle²,

2008

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Depression is one of the most prevalent and debilitating of the psychiatric disorders. Studies have shown that cognitive therapy is as efficacious as antidepressant medications at treating depression, and it seems to reduce the risk of relapse even after its discontinuation. Cognitive therapy and antidepressant medication probably engage some similar neural mechanisms, as well as mechanisms that are distinctive to each. A precise specification of these mechanisms might one day be used to guide treatment selection and improve outcomes.

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Section: Outcomes Of Ct Versus Admmentioning

confidence: 81%

Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms

Siegle²,

2008

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“…antidepressants, psychotherapy) improve all types of depressive symptoms (Bhar et al, 2008; Stewart and Harkness, 2012). However, substantial heterogeneity exists with respect to symptom patterns of depression in patients with CHD (Ormel and de Jonge 2011; Poole et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Changes in cognitive versus somatic symptoms of depression and event-free survival following acute myocardial infarction in the Enhancing Recovery In Coronary Heart Disease (ENRICHD) study

Roest¹,

Carney²,

Freedland³

et al. 2013

Journal of Affective Disorders

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Background Randomized controlled trials focusing on the effects of antidepressant treatment in cardiac patients have found modest effects on depressive symptoms but not on cardiac outcomes. A secondary analysis was conducted on data from the Enhancing Recovery in Coronary Heart Disease trial to assess whether changes in somatic or cognitive depressive symptoms following acute MI predicted event-free survival and whether the results differed per treatment arm (cognitive behavior therapy or care as usual). Methods Patients who met depression criteria and completed the 6th month depression assessment (n=1254) were included in this study. Measurements included demographic and clinical data and the Beck Depression Inventory at baseline and 6 months. The primary endpoint was a composite of recurrent MI and mortality over 2.4 years (standard deviation=0.9 years). Results Positive changes (per 1 point increase) in somatic depressive symptoms (HR: 0.95; 95% CI: 0.92–0.98; p=0.001) but not in cognitive depressive symptoms (HR: 0.98; 95% CI: 0.96–1.01; p=0.19) were related to a reduced risk of recurrent MI and mortality after adjustment for baseline depression scores. There was a trend for an interaction effect between changes in somatic depressive symptoms and the intervention (p=0.08). After controlling for demographic and clinical variables, the association between changes in somatic depressive symptoms and event-free survival remained significant in the intervention arm (HR: 0.93; 95% CI: 0.88–0.98; p=0.01) only. Limitations Secondary analyses. Conclusions Changes in somatic depressive symptoms, and not cognitive symptoms, were related to improved outcomes in the intervention arm, independent of demographic and clinical variables.

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“…Structured interviews and questionnaires, such as the Hamilton Depression Rating Scale (HAMD; Hamilton, 1960) and Beck Depression Inventory (BDI; Beck et al 1961;BDI-II;Beck et al 1996b) are important and commonly used tools to screen for, study, and follow the course of MDD (Beck et al 1996a). Bhar et al 2008;Stewart & Harkness, 2012;Fournier et al 2013). Relatively few studies use a more fine-grained analysis, in which the reduction of depression severity is studied by examining specific (clusters of) symptoms of depression instead of using the total score (e.g.…”

Section: Introductionmentioning

confidence: 99%

Revealing the dynamic network structure of the Beck Depression Inventory-II

et al. 2014

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Sequence of improvement in depressive symptoms across cognitive therapy and pharmacotherapy

Abstract: Background-The authors examined the patterns of improvement in cognitive and vegetative symptoms of major depression in individuals treated with cognitive therapy (CT) or pharmacotherapy (PT).

Cited by 26 publications

References 19 publications

Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms

Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms

Changes in cognitive versus somatic symptoms of depression and event-free survival following acute myocardial infarction in the Enhancing Recovery In Coronary Heart Disease (ENRICHD) study

Revealing the dynamic network structure of the Beck Depression Inventory-II

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