Sequence of epicardial repolarisation and configuration of the T wave.

Cowan, J. C.; Hilton, Colin J.; Griffiths, Clive; Tansuphaswadikul, S.; Bourke, John; Murray, Alan; Campbell, R. W. F.

doi:10.1136/hrt.60.5.424

Cited by 130 publications

(78 citation statements)

References 25 publications

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“…The available, which is in fact the reason for the ongoing discussion on this topic mentioned in the introduction. However, the results were in agreement with those from the sparse invasive studies available [35,36]. Moreover, the results are in full qualitative agreement with those observed, by means of essentially the same method, when applied to several healthy individuals.…”

Section: B the Normal T Wavesupporting

confidence: 88%

Measuring the T Wave of the Electrocardiogram; The How and Why

Oosterom¹

2009

Measurement Science Review

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Section: B the Normal T Wavesupporting

confidence: 88%

Measuring the T Wave of the Electrocardiogram; The How and Why

Oosterom¹

2009

Measurement Science Review

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“…QT interval length was usually measured in the ventral (V)2 and V3 leads using a digitiser (CalComp, Newbury, Berks, UK). Measurements in V2 and V3 were chosen, since they provide a close approximation of maximal QT [23]. QT interval length was measured from the onset of the QRS to the end of the T wave.…”

Section: Study Populationmentioning

confidence: 99%

QTc interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up

et al. 2006

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Aims/hypothesis We evaluated the association of QT interval corrected for heart rate (QT c ) and resting heart rate (rHR) with mortality (all-causes, cardiovascular, cardiac, and ischaemic heart disease) in subjects with type 1 and type 2 diabetes. Methods We followed 523 diabetic patients (221 with type 1 diabetes, 302 with type 2 diabetes) who were recruited between 1974 and 1977 in Switzerland for the WHO Multinational Study of Vascular Disease in Diabetes. Duration of follow-up was 22.6±0.6 years. Causes of death were obtained from death certificates, hospital records, post-mortem reports, and additional information given by treating physicians.

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“…The measurement on the thoracic leads was performed by a single investigator, who was blinded with respect to the patient characteristics. The dispersion of QTc was calculated using the difference between the maximum and minimum QTc in any thoracic lead (6,11). A QTd Ͼ0.080 s was considered abnormally increased.…”

Section: Q-t Interval Dispersionmentioning

confidence: 99%

Prevalence of Q-T Interval Dispersion in Type 1 Diabetes and Its Relation With Cardiac Ischemia

Veglio¹,

Giunti²,

Stevens³

et al. 2002

Diabetes Care

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OBJECTIVE -The interlead variation in duration of the Q-T interval on the surface electrocardiogram (Q-T interval dispersion [QTd]) has been shown to predict mortality in type 2 diabetic patients. We evaluated the prevalence of QTd prolongation in the EURODIAB population and its relation to corrected Q-T interval (QTc), sex, age, duration of diabetes, blood glucose control, and complications.RESEARCH DESIGN AND METHODS -A total of 3,042 type 1 diabetic patients were studied. QTc was calculated according to the Bazett's formula; QTc Ͼ0.44 s was considered abnormally prolonged. QTd was calculated using the difference between the maximum and the minimum QTc in any thoracic lead. QTd Ͼ0.080 s was considered abnormally prolonged.RESULTS -The prevalence of an increased QTd was 7%. A significant relation was observed between QTd prolongation and diastolic blood pressure (P Ͻ 0.05). A higher prevalence of QTd prolongation was observed in patients with ischemic heart disease (P ϭ 0.004), whereas no relationship was observed with retinopathy, albumin excretion rate, or measures of somatic and autonomic neuropathy. QTc and QTd were significantly related (P ϭ 0.001); however, a proportion of patients with normal QTd showed a prolonged QTc (Ͼ0.44 s).CONCLUSIONS -In patients with type 1 diabetes, QTd is associated with ischemic heart disease and diastolic blood pressure but not neuropathy. Although QTd is statistically related to duration of QTc, increased QTd and increased QTc identify different patients, and their predictive value deserves prospective evaluation. Diabetes Care 25:702-707, 2002T he Q-T interval in the electrocardiogram (ECG) reflects the total duration of ventricular myocardial depolarization and repolarization. It has been shown that a prolonged Q-T interval is associated with sudden death and poor survival in healthy subjects (1) and in a variety of clinical conditions, including newly diagnosed type 2 diabetes (2), nephropathy (3), and type 1 diabetes (4,5).The observation that the Q-T interval exhibits a certain degree of spatial variability on the epicardial surface (6) has led to the hypothesis that differences in the duration of the Q-T interval between ECG leads may reflect heterogeneity in recovery of excitability (7). Based on the evidence that nonuniform repolarization provides a substrate for the development of malignant ventricular arrhythmias (8), variation in the duration of the Q-T interval has been advocated as a more predictive marker of arrhythmias and mortality than the maximum duration of the Q-T interval (9).The interlead variation in duration of the Q-T interval on the surface ECG has been referred to as Q-T interval length dispersion or Q-T dispersion (QTd). It has been shown that the QTd is predictive of mortality in normal subjects and different groups of patients. Increased QTd has been described in patients with recent myocardial infarction (10), long Q-T syndrome (9,11), heart failure (12), and hypertrophic cardiomyopathy (13). Furthermore, QTd has been related to arrhythmia and ...

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Sequence of epicardial repolarisation and configuration of the T wave.

Cited by 130 publications

References 25 publications

Measuring the T Wave of the Electrocardiogram; The How and Why

Measuring the T Wave of the Electrocardiogram; The How and Why

QTc interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up

Prevalence of Q-T Interval Dispersion in Type 1 Diabetes and Its Relation With Cardiac Ischemia

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