Five 3rd-order depositional sequences are interpreted from the early Albian to late Campanian interval in the Potiguar Basin. An integrated analysis of seismic interpretations, well logs, cores and biostratigraphic data provides a stratigraphic framework composed by stratigraphic surfaces, systems tracts and sequences. Depositional Sequence 1 and 2 are, respectively, Albian and early to mid-Cenomanian aged and are composed by the falling stage, low stand, transgressive and high stand systems tracts. Depositional Sequence 3 is late Cenomanian to mid-Turonian aged and is composed by the transgressive and high stand systems tracts. Depositional sequences 4 and 5 are, respectively, late Turonian to mid-Santonian and late Santonian to mid-Campanian aged and are composed only by transgressive and high stand systems tracts. The lack of falling stage and low stand systems tracts in depositional sequences 3, 4 and 5, as well the increasing in transgressive and highstand systems tracts thickness as depositional sequences get younger, are reflection of an overall transgressive trend of a 2nd-order sequence. The interpretation proposed in this paper correlates onshore with offshore deposits within a seismic scale (3rd-order) sequence stratigraphy framework. This approach allows a better understanding of the Açu Formation, the primary oil-bearing formation of the Potiguar Basin. The Açu Formation is part of depositional sequences 1, 2 and 3 and is characterized by lateral and vertical variations of depositional systems instead of being associated to a specific depositional system. This sequence stratigraphy analysis can be used as a low-resolution framework for future high-resolution (4th-order scale) studies.