Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus

Mahler, Kimberly L; Fleming, Jessica L.; Dworkin, Amy M.; Gladman, Nicholas; Cho, Hee‐Yeon; Mao, Jian‐Hua; Balmain, Allan; Toland, Amanda E.

doi:10.1186/1471-2164-9-626

Cited by 16 publications

(26 citation statements)

References 37 publications

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“…The high sequence divergence of M. spretus from other members of the Palearctic clade and its outgroup appearance within the clade supports the view that the lineage leading to M. spretus diverged earlier before split of the lineage leading to other species of the Palearctic clade (Prager et al 1996 and references there in). The instability in position of M. spretus within the clade may be due to the rapid speciation of this Palaeartic lineage (Lundrigan et al 2002) or may be due to differences in selection pressure between M. musculus and M. spretus (Mahler et al 2008) after the diversification of the lineage.…”

Section: Phylogenetic Relationshipsmentioning

confidence: 97%

Phylogenetic relationship and time of divergence of Mus terricolor with reference to other Mus species

Rudra

Chatterjee

Bahadur

2016

J Genet

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Mitochondrial DNA control region of Mus terricolor, three aboriginal species M. spretus, M. macedonicus, M. spicilegus; the Asian lineage M. caroli, M. cervicolor, M. cookii; and the two house mice, M. musculus domesticus and M. m. castaneus were analysed to estimate the substitution rate, phylogenetic relationship and the probable time of divergence. Results showed that M. spretus, M. caroli and M. terricolor are highly diverged from each other (caroli/terricolor = 0.146, caroli/spretus = 0.147 and terricolor/spretus = 0.122), whereas M. spretus showed less divergence with two house mice species (0.070 and 0.071). Sequence divergence between M. terricolor and the Palearctic group were found to be ranging from 0.121 to 0.134. Phylogenetic analysis by minimum evolution, neighbour-joining, unweighed pair group method with arithmetic mean and maximum parsimony showed almost similar topology. Two major clusters were found, one included the Asian lineage, M. caroli, M. cookii and M. cervicolor and the other included the house mice M. m. domesticus, M. m. castaneus and the aboriginal mice M. macedonicus and M. spicilegus along with M. spretus, forming the Palearctic clade. M. terricolor was positioned between the Palearctic and Asian clades. Results showed that Palearctic-terricolor and the Asian lineages diverged 5.47 million years ago (Mya), while M. terricolor had split around 4.63 Mya from their ancestor. M. cervicolor, M. cookii and M. caroli diverged between 4.70 and 3.36 Mya, which indicates that M. terricolor and the Asian lineages evolved simultaneously. M. spretus is expected to have diverged nearly 2.9 Mya from their most recent common ancestor.

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Section: Phylogenetic Relationshipsmentioning

confidence: 97%

Phylogenetic relationship and time of divergence of Mus terricolor with reference to other Mus species

Rudra

Chatterjee

Bahadur

2016

J Genet

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“…The distribution pattern for sensitivity to tumor promotion by TPA (SENCAR > DBA/2 ≥ CD-1 > C3H/He >> C57BL/6) has been well documented reviewed in 55 . A number of chromosomal loci underlying this complex trait have been identified in various stocks and strains of mice 56–63 . A similar distribution pattern for the sensitivity to different classes of promoting agents suggests that common genetic factors modify the response to tumor promotion by different classes of promoting agents 64 .…”

Section: Introductionmentioning

confidence: 99%

Multi-stage chemical carcinogenesis in mouse skin: Fundamentals and applications

et al. 2009

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For more than 60 years, the chemical induction of tumors in mouse skin has been used to study mechanisms of epithelial carcinogenesis and evaluate modifying factors. In the traditional two-stage skin carcinogenesis model, initiation is accomplished by the application of a subcarcinogenic dose of a carcinogen. Subsequently, tumor development is elicited by repeated treatment with a tumor promoting agent. The initiation protocol can be completed within 1–3 hours depending on the number of mice used, while the promotion phase requires twice weekly treatments (1–2 hours) and once weekly tumor palpation (1–2 hours) for the duration of the study. A highly reproducible papilloma burden is expected within 10–20 weeks with progression of a portion of the tumors to squamous cell carcinomas within 20–50 weeks. In contrast to complete skin carcinogenesis, the two-stage model allows for greater yield of premalignant lesions as well as separation of the initiation and promotion phases.

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“…In previous linkage studies of dimethylbenz [a] anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)- induced skin cancer a number of skin cancer susceptibility loci were identified in SPRET/Outbred by NIH/Ola F1 backcross mice [1]–[4]. Linkage studies were also performed using SPRET/EiJ by FVB/N, SPRET/EiJ by NIH/Ola and STF/Pas by NIH/Ola F1 backcross mice which identified additional susceptibility loci.…”

Section: Introductionmentioning

confidence: 99%

The Impact of 3′UTR Variants on Differential Expression of Candidate Cancer Susceptibility Genes

et al. 2013

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Variants in regulatory regions are predicted to play an important role in disease susceptibility of common diseases. Polymorphisms mapping to microRNA (miRNA) binding sites have been shown to disrupt the ability of miRNAs to target genes resulting in differential mRNA and protein expression. Skin tumor susceptibility 5 (Skts5) was identified as a locus conferring susceptibility to chemically-induced skin cancer in NIH/Ola by SPRET/Outbred F1 backcrosses. To determine if polymorphisms between the strains which mapped to putative miRNA binding sites in the 3′ untranslated region (3′UTR) of genes at Skts5 influenced expression, we conducted a systematic evaluation of 3′UTRs of candidate genes across this locus. Nine genes had polymorphisms in their 3′UTRs which fit the linkage data and eight of these contained polymorphisms suspected to interfere with or introduce miRNA binding. 3′UTRs of six genes, Bcap29, Dgkb, Hbp1, Pik3cg, Twistnb, and Tspan13 differentially affected luciferase expression, but did not appear to be differentially regulated by the evaluated miRNAs predicted to bind to only one of the two isoforms. 3′UTRs from four additional genes chosen from the locus that fit less stringent criteria were evaluated. Ifrd1 and Etv1 showed differences and contained polymorphisms predicted to disrupt or create miRNA binding sites but showed no difference in regulation by the miRNAs tested. In summary, multiple 3′UTRs with putative functional variants between susceptible and resistant strains of mice influenced differential expression independent of predicted miRNA binding.

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Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus

Cited by 16 publications

References 37 publications

Phylogenetic relationship and time of divergence of Mus terricolor with reference to other Mus species

Phylogenetic relationship and time of divergence of Mus terricolor with reference to other Mus species

Multi-stage chemical carcinogenesis in mouse skin: Fundamentals and applications

The Impact of 3′UTR Variants on Differential Expression of Candidate Cancer Susceptibility Genes

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