Sequence determination and anticoagulant and antithrombotic activities of a novel sulfated fucan isolated from the sea cucumber Isostichopus badionotus

Fucosylated Chondroitin Sulfate from Sea Cucumber in Combination with Rosiglitazone Improved Glucose Metabolism in the Liver of the Insulin-Resistant Mice

“…1, CHS from sea cucumber is an acid glycosaminoglycan composed of a chondroitin sulfate-E backbone with branches of sulfated fucose at a ratio of approximately 30%, a distinguishing feature different from CHS isolated from other species. 8) Current reports on the bioactivities of this component focus mainly on anticoagulation, [8][9][10][11] antithrombosis, 8,10) and antitumor. 12,13) But as far as we know, there is not any report on CHS from sea cucumber.…”

Structure and rheological characteristics of fucoidan from sea cucumber Apostichopus japonicus

“…While fucoidan from sea cucumber L. grisea, I. badionotus, A. molpadioides and T. ananas are all linear polysaccharide; branch structure and 1,4-linkage are absent in those fucoidan (Chen et al, 2012;Mulloy et al, 1994;. Although two fucoidans with branch structure have been found in Stichopus japonicus by Kariya et al (2004), it should be noticed that they are extracted by using organic solvent (chloroform-methanol) while other reported sea cucumber fucoidans including Aj-FUC are all extracted in aqueous phase.…”

“…Biological activity of polysaccharide has a profound relationship with its structure, and several studies have focused on the structural analysis of sea cucumber fucoidan. Mulloy, Ribeiro, Alves, Vieira, and Mourao (1994), Chen et al (2012) clarified the structure of fucoidan from Ludwigothurea grisea and Isostichopus badionotus respectively, and the delicate structures of fucoidan from Acaudina molpadioides and Thelenota ananas were recently elucidated by us . All these fucoidans are linear polysaccharides, consisting of tetrasaccharide repeating units with diverse sulphated patterns ( Supplementary Fig.…”

A historical perspective of the biophysics of the thrombin–heparin system: an example of nonspecific binding and the consequent parking problem in action

“…Discovery of the anticoagulant activity of heparin has led not only to its widespread clinical use but also to the search for other highly-sulfated polysaccharides as heparin substitutes/supplanters-a search that is ongoing (Chen et al 2012;Fernández et al 2013) despite concurrent emphasis on direct thrombin inhibitors (Coppens et al 2012;Marson et al 2012). Heparin, a sulfated glycosaminoglycan in which the repeat unit is a disaccharide comprising α-L-iduronic acid-2-sulfate linked β-1,4 to Nsulfurylglucosamine-6-sulfate, exerts its therapeutic effect by catalyzing the antithrombin-mediated inhibition of various coagulation proteases (Björk and Lindahl 1982;Björk et al 1989).…”