Sequence Analysis of Exon 8 of MAO-A Gene in Alcoholics with Antisocial Personality and Normal Controls

Parsian, Abbas

doi:10.1006/geno.1998.5664

Cited by 35 publications

(19 citation statements)

References 14 publications

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“…Early-onset alcohol dependence with antisocial traits has consistently been reported to be associated with MAOA alleles that imply low MAO activity: MAOA (CA) n , Parsian et al (1995); MAOA (VNTR), Gade et al (1998); MAOA (T1460C), Parsian (1999) and Parsian and Cloninger (2001); MAOA-LPR, Samochowiec et al (1999). Gade et al (1998) found one VNTR allele to be more frequent in substance-dependent patients (a group that may have AAL characteristics), compared with purely alcohol-dependent patients.…”

Section: Discussionmentioning

confidence: 98%

“…Although there is some disagreement, overall there is significant evidence for association of MAOA with AAL. Parsian (1999) found both the T1460C and Fnu markers significantly associated with AAL, but not the CA repeat (see also Parsian and Cloninger, 2001). For an AAL subtype, Parsian (1999) verified case-control differences in haplotypes of MAOA by testing a small sam-ple of mothers by the transmission disequilibrium test.…”

Section: Introductionmentioning

confidence: 85%

“…Parsian (1999) found both the T1460C and Fnu markers significantly associated with AAL, but not the CA repeat (see also Parsian and Cloninger, 2001). For an AAL subtype, Parsian (1999) verified case-control differences in haplotypes of MAOA by testing a small sam-ple of mothers by the transmission disequilibrium test. Gade et al (1998) found one VNTR allele to be higher for substance abuse patients, compared with alcohol-dependent patients.…”

Section: Introductionmentioning

confidence: 85%

See 2 more Smart Citations

Antisocial alcoholism and serotonin-related polymorphisms: association tests

Hill

Stoltenberg²,

Bullard

et al. 2002

Psychiatric Genetics

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 85%

See 1 more Smart Citation

Antisocial alcoholism and serotonin-related polymorphisms: association tests

Hill

Stoltenberg²,

Bullard

et al. 2002

Psychiatric Genetics

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“…133,[143][144][145][146][147][148][149][150][151] No association findings with antidepressant response can also be found in the literature. 81,152,153 Moreover, it has been reported that the 941T>G polymorphism (rs6323) in the MAOA gene is associated with mirtazapine response in girls and women.…”

Section: Monoamine Oxidase Amentioning

confidence: 98%

Pharmacogenetics of antidepressant response

Porcelli

Drago

Fabbri

et al. 2011

J Psychiatry Neurosci

157

103

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87Personalized medicine -the adaptation of therapies based on an individual's genetic and molecular profile -is one of the most promising aspects of modern medicine. The identification of the relation between genotype and drug response, including both the therapeutic effect and side effect profile, is expected to deeply affect medical practice. In this paper, we review the current knowledge about the genes related to antidepressant treatment response and provide methodologic proposals for future studies. We have mainly focused on genes associated with pharmacodynamics, for which a list of promising genes has been identified despite some inconsistency across studies. We have also synthesized the main results for pharmacokinetic genes, although so far they seem less relevant than those for pharmaco dynamic genes. We discuss possible reasons for these inconsistent findings and propose new study designs.

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“…A variant of the tyrosine hydroxylase enzyme, which is involved in the synthesis of dopamine, is associated with early-onset alcoholism (Dahmen, Volp, Singer, Hiemke & Szegedi, 2005). Besides, certain variants in the genes encoding for dopamine metabolizing enzyme monoamine oxidase A and the dopamine D2 receptor are associated with the emergence of antisocial personality traits and a higher proneness for alcoholism (Parsian, 1999;T. J. Wang et al, 2007).…”

Section: Dopaminergic Systemmentioning

confidence: 99%

Alteraciones neurobiológicas en el alcoholismo: revisión

Erdozain

Callado

2014

Adicciones

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The exact mechanism by which ethanol exerts its effects on the brain is still unknown. However, nowadays it is well known that ethanol interacts with specific neuronal membrane proteins involved in signal transmission, resulting in changes in neural activity. In this review different neurochemical alterations produced by ethanol are described. Primarily, ethanol interacts with two membrane receptors: GABA A and NMDA ion channel receptors. Ethanol enhances the GABA action and antagonizes glutamate action, therefore acting as a CNS depressant. In addition, ethanol affects most other neurochemical and endocrine systems. In regard to the brain reward system, both dopaminergic and opioid system are affected by this drug. Furthermore, the serotonergic, noradrenergic, corticotropinreleasing factor and cannabinoid systems seem to play an important role in the neurobiology of alcoholism. At last but not least, ethanol can also modulate cytoplasmic components, including the second messengers. We also review briefly the different actual and putative pharmacological treatments for alcoholism, based on the alterations produced by this drug.

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Sequence Analysis of Exon 8 of MAO-A Gene in Alcoholics with Antisocial Personality and Normal Controls

Cited by 35 publications

References 14 publications

Antisocial alcoholism and serotonin-related polymorphisms: association tests

Antisocial alcoholism and serotonin-related polymorphisms: association tests

Pharmacogenetics of antidepressant response

Alteraciones neurobiológicas en el alcoholismo: revisión

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