Sequelae of Arrested Mild Retinopathy of Prematurity

Schaffer, David B.; Quinn, Graham E.; Johnson, Lois

doi:10.1001/archopht.1984.01040030291021

Cited by 65 publications

(22 citation statements)

References 9 publications

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“…19 Quinn et al 14 reported a 4.8% incidence of anisometropia in 1548 ROP infants. The increased incidence of anisometropia in resolved ROP is not unexpected, because many cases of regressed ROP are asymmetric regarding the final peripheral retinal fibrosis.…”

Section: Discussionmentioning

confidence: 41%

“…This asymmetry may contribute to the occurrence of anisometropia. 18,19 In this study, the presence of anisometropia and a higher degree of astigmatism are also found in laser-treated ROP. We also demonstrate that significant anisometropia (X1.5 D) is often associated with impaired visual function in patients with lasertreated ROP.…”

Section: Discussionmentioning

confidence: 43%

“…[18][19][20][21] The incidence of strabismus is reported to be higher in infants with regressed ROP (34%) in comparison with premature infants without ROP (16%). Furthermore, the incidence of strabismus rose with the severity of ROP.…”

Section: Discussionmentioning

confidence: 45%

“…Furthermore, the incidence of strabismus rose with the severity of ROP. 19,20,22 In this study, strabismus occurred in 30.0% of the patients with lasertreated threshold ROP. Meanwhile, impaired visual acuity is more frequent among premature infants with visual pathway damage.…”

Section: Discussionmentioning

confidence: 47%

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Long-term visual outcomes of laser-treated threshold retinopathy of prematurity: a study of refractive status at 7 years

Yang

Wang

Sung

et al. 2009

Eye

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Section: Discussionmentioning

confidence: 41%

Section: Discussionmentioning

confidence: 43%

Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 47%

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Long-term visual outcomes of laser-treated threshold retinopathy of prematurity: a study of refractive status at 7 years

Yang

Wang

Sung

et al. 2009

Eye

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“…11 28 29 Schaffer et al 30 found the degree and frequency of myopia to be similar in premature infants with low grade retinopathy of prematurity (ROP) and no retinopathy. In our study, only one eye in the spontaneously regressed subthreshold group developed high myopia.…”

Section: Myopiamentioning

confidence: 99%

Treated threshold stage 3 versus spontaneously regressed subthreshold stage 3 retinopathy of prematurity: a study of motility, refractive, and anatomical outcomes at 6 months and 36 months

Sahni

Subhedar²,

Clark³

2005

British Journal of Ophthalmology

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Aim: To compare the visual acuity (VA), spherical equivalent refractive error, motility, and anatomical outcomes in children with treated regressed threshold stage 3 retinopathy of prematurity (ROP) and those with spontaneously regressed subthreshold stage 3 ROP. Method: 6 month and 3 year data collected from infants examined between 1989 and 1999 with regressed stage 3 ROP, with or without treatment were retrospectively reviewed. Results: 85 infants were included in this study. 40 eyes received cryotherapy, 81 eyes laser photocoagulation, and 34 eyes had spontaneously regressed subthreshold stage 3 ROP. Grating acuity score >2 cycles/degree (c/d) at 6 months was predictive of optotype acuity >6/9 in 69% of eyes and a score ,2 c/d at 6 months was predictive of acuity ,6/9 in 88% of eyes. Eyes with subthreshold stage 3 ROP were twice as likely to have VA of 6/9 or better at 36 months than the treated eyes. The mean spherical equivalent refractive error at 36 months was 26.5 dioptres (D) (221.5D to +1.38D) in cryotherapy treated eyes, 22.4D (213D to +4D) in the laser group, and 20.22D (29D to +2.25D) in the subthreshold group. Eyes within the treated groups were more myopic than the eyes within the spontaneously regressed group (p = 0.005). At 36 months, 42 out of the 85 infants (that is, 49%) had strabismus (44% in the cryotherapy group, 26% in the laser group, and 25% in the subthreshold group). There was a statistically significant association between the presence of strabismus and anisometropia (p = 0.016) and strabismus and intraventricular haemorrhage (IVH) (p = 0.005). There was a statistically significant difference in the incidence of strabismus between mild and moderate and severe grade IVH (p = 0.01). Eight out of 40 eyes in the cryotherapy group and six out of the 81 eyes in the laser group developed macular ectopia. None of the eyes in the spontaneously regressed group had macular dragging. Conclusions: In this study, the grating acuity at 6 months was a good predictor of the 3 year optotype acuity in all groups. Eyes with spontaneously regressed subthreshold stage 3 ROP were associated with better vision at 3 years of age and a lesser degree of myopia compared to the treated groups. Strabismus developed predominantly in the treated groups and was frequently associated with neurological damage and/or anisometropia. The spontaneously regressed subthreshold stage 3 group had a better anatomical outcome compared to the groups in which the retinopathy regressed following treatment.

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