Septopremaxillary Ligament Resection and Midfacial Growth in a Chimpanzee Animal Model

Siegel, Michael I.; Mooney, Mark P.; Eichberg, Jorg W.; Gest, Thomas R.; Lee, D R

doi:10.1097/00001665-199001040-00006

Cited by 32 publications

(42 citation statements)

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“…The experimental group exhibited both an absolute and relative increase in premaxillary length. Thus, although facial length was reduced, the continued expansion of the nasal septum presumably produced compensatory premaxillary growth, likely via the septo-premaxillary ligament (e.g., Latham, 1970;Siegel, 1986, 1991;Siegel et al, 1990). The relative increase in premaxillary length was further reflected in the multivariate geometric morphometric analysis.…”

Section: Discussionmentioning

confidence: 99%

“…The nasal septal traction model emphasizes the morphogenetic capacity of the nasal septum and considers the midface, including the premaxilla, as responsive to developmentally induced biomechanical forces placed on the facial skeleton (e.g., along the premaxillary suture) during septal expansion (e.g., Scott, 1953). Thus, as the nasal septum increases in length, tension is placed on the premaxilla via the septo-premaxillary ligament (Latham, 1970;Gange and Johnston, 1974;Siegel, 1986, 1991;Siegel et al, 1990). This dynamic results from the nasal septal cartilage acting as a growth plate, which develops through a combination of interstitial cellular division, chondrocyte hypertrophy, and endochondral ossification along its caudal border (Scott, 1953;Baume, 1961;Catala and Johnston, 1980;Copray, 1986;Wealthall and Herring, 2006).…”

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confidence: 99%

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Nasal Septal and Premaxillary Developmental Integration: Implications for Facial Reduction in Homo

Holton

Franciscus

Marshall

et al. 2010

The Anatomical Record

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The influence of the chondrocranium in craniofacial development and its role in the reduction of facial size and projection in the genus Homo is incompletely understood. As one component of the chondrocranium, the nasal septum has been argued to play a significant role in human midfacial growth, particularly with respect to its interaction with the premaxilla during prenatal and early postnatal development. Thus, understanding the precise role of nasal septal growth on the facial skeleton is potentially informative with respect to the evolutionary change in craniofacial form. In this study, we assessed the integrative effects of the nasal septum and premaxilla by experimentally reducing facial length in Sus scrofa via circummaxillary suture fixation. Following from the nasal septal-traction model, we tested the following hypotheses: (1) facial growth restriction produces no change in nasal septum length; and (2) restriction of facial length produces compensatory premaxillary growth due to continued nasal septal growth. With respect to hypothesis 1, we found no significant differences in septum length (using the vomer as a proxy) in our experimental (n ¼ 10), control (n ¼ 9) and surgical sham (n ¼ 9) trial groups. With respect to hypothesis 2, the experimental group exhibited a significant increase in premaxilla length. Our hypotheses were further supported by multivariate geometric morphometric analysis and support an integrative relationship between the nasal septum and premaxilla. Thus, continued assessment of the growth and integration of the nasal septum and premaxilla is potentially informative regarding the complex developmental mechanisms that underlie facial reduction in genus Homo evolution. Anat Rec, 294:68-78, 2011. V V C 2010 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Nasal Septal and Premaxillary Developmental Integration: Implications for Facial Reduction in Homo

Holton

Franciscus

Marshall

et al. 2010

The Anatomical Record

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“…variability in the range of ANT morphologies seen within sexes in the present stud , and the multi le tubercles noted by Ec Elated to variations in the attachment site(s) of the septopremaxillary ligament (SPL) to the face of the remaxilla. Recent ex erimental findings gy Siegel et al (1990) Rave shown significant growth deficits in the premaxillary component following SPL resection in 120 day old chimpanzees com ared to ment an important role of the SPL for early anterior displacement of the midface in the chimpanzee. Further dissection and histological examination of the SPL and ANT regions in chim anzees are needed to eluci-Y l be t f e case in the more pro athic, male maxi P lary sutures close, slowing midfacial hardt (persona P communication), may be resham operated controls.…”

Section: Methodsmentioning

confidence: 96%

Premaxillary‐maxillary suture fusion and anterior nasal tubercle morphology in the chimpanzee

Mooney

Siegel

1991

American J Phys Anthropol

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The anterior nasal spine (ANS) is considered by some to be a unique characteristic of modern humans; however, it has been reported to occur in chimpanzees. Among human populations, ANS size correlates with facial prognathism and timing of premaxillary-maxillary sutural fusion, which may have implications for models of midfacial growth. To investigate these questions, skulls from 55 chimpanzees (Pan troglodytes) (29 male, 26 female), ranging in age from infants to adults, were examined. None of the 55 specimens examined had a true ANS, but a number of specimens exhibited raised anterior nasal prominences or tubercles (ANT) on the nasal surface of the premaxilla. Female specimens had significantly (P less than .05) more ANTs and more extensive fusion of both the palatal and facial components of the suture than did the male specimens. Results from the present study document the presence of an ANT in a sample of chimpanzee crania and are consonant with associations predicted by a septal-traction model of midfacial growth.

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“…This was the case until removal of the distractors after 6 weeks according to the protocol, and indicates that, in the palatal region, 6 weeks of retention provides a good balance between fixation for osteogenesis and early exposure to functional loads for remodeling 13,22,23 . Since the palatal bone shelf in the radiographs of this region was not shown in strong contrast, the newly formed trabeculae that oriented in parallel to the distraction vector could be easily identified like in other sites 12,13,24,25 .…”

Section: Discussionmentioning

confidence: 93%

A new approach to repairing cleft palate and acquired palatal defects with distraction osteogenesis

Wang

Chen

Liao

et al. 2006

International Journal of Oral and Maxillofacial Surgery

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Septopremaxillary Ligament Resection and Midfacial Growth in a Chimpanzee Animal Model

Cited by 32 publications

References 0 publications

Nasal Septal and Premaxillary Developmental Integration: Implications for Facial Reduction in Homo

Nasal Septal and Premaxillary Developmental Integration: Implications for Facial Reduction in Homo

Premaxillary‐maxillary suture fusion and anterior nasal tubercle morphology in the chimpanzee

A new approach to repairing cleft palate and acquired palatal defects with distraction osteogenesis

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