Septo-hippocampal relationship during EEG theta rhythm

Gaztelu, J.M.; Buño, Washington

doi:10.1016/0013-4694(82)90201-2

Cited by 92 publications

(46 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, a similar muscarinic long-lasting enhancement of SC EPSPs may be induced by tetanic stimulation of septohippocampal cholinergic fibers, suggesting that LTP IP3 may be functional in the natural condition. This view is consistent with the high firing rates of medial septal neurons in vivo (Gogolak et al, 1968;Gaztelu and Buno, 1982). This novel LTP IP3 indicates that sustained modifications of synaptic efficacy may be more diverse than previously considered and reveals yet another cascade of postsynaptic events that might be present during behavior and can drive AMPARs into synapses and enhance synaptic transmission exclusively through Ca 2ϩ release from ER stores.…”

Section: Discussionsupporting

confidence: 80%

“…The high-frequency stimulation (HFS) of the medial septum used to induce long-term potentiation (LTP) consisted of three 500 ms duration pulse barrages of 100 A, 0.3 ms pulses at 100 Hz presented every 2 s delivered without SC stimulation. The stimulation frequency of 100 Hz is similar to the discharge rate exhibited by groups of medial septal neurons (Gaztelu and Buno, 1982;Zenchenko et al, 2000), suggesting that high firing rate activity could be present in physiological conditions.…”

Section: Methodsmentioning

confidence: 57%

See 1 more Smart Citation

Cholinergic-Mediated IP₃-Receptor Activation Induces Long-Lasting Synaptic Enhancement in CA1 Pyramidal Neurons

Sevilla¹,

Núñez²,

Borde³

et al. 2008

J. Neurosci.

129

View full text Add to dashboard Cite

Cholinergic-glutamatergic interactions influence forms of synaptic plasticity that are thought to mediate memory and learning. We tested in vitro the induction of long-lasting synaptic enhancement at Schaffer collaterals by acetylcholine (ACh) at the apical dendrite of CA1 pyramidal neurons and in vivo by stimulation of cholinergic afferents. In vitro ACh induced a Ca 2ϩ wave and synaptic enhancement mediated by insertion of AMPA receptors in spines. Activation of muscarinic ACh receptors (mAChRs) and Ca 2ϩ release from inositol 1,4,5-trisphosphate (IP 3 )-sensitive stores were required for this synaptic enhancement that was insensitive to blockade of NMDA receptors and also triggered by IP 3 uncaging. Activation of cholinergic afferents in vivo induced an analogous atropine-sensitive synaptic enhancement. We describe a novel form of synaptic enhancement (LTP IP3 ) that is induced in vitro and in vivo by activation of mAChRs. We conclude that Ca 2ϩ released from postsynaptic endoplasmic reticulum stores is the critical event in the induction of this unique form of long-lasting synaptic enhancement.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Methodsmentioning

confidence: 57%

Cholinergic-Mediated IP₃-Receptor Activation Induces Long-Lasting Synaptic Enhancement in CA1 Pyramidal Neurons

Sevilla¹,

Núñez²,

Borde³

et al. 2008

J. Neurosci.

129

View full text Add to dashboard Cite

show abstract

“…In addition to the extensively studied fast-firing, rhythmic-bursting neurons, many MSvDB neurons are nonetheless slow-firing and do not fire theta-range rhythmic bursts (Ford et al 1989;Gaztelu and Buno 1982;Stewart and Fox 1989). As such, these latter cells are unlikely candidates to participate in pacing theta oscillations.…”

mentioning

confidence: 99%

A distinctive subpopulation of medial septal slow-firing neurons promote hippocampal activation and theta oscillations

Zhang

Lin

Nicolelis

2011

Journal of Neurophysiology

View full text Add to dashboard Cite

Although many previous studies have focused on understanding how MSVDB neurons fire rhythmic bursts to pace hippocampal theta oscillations, a significant portion of MSVDB neurons are slow-firing and thus do not pace theta oscillations. The function of these MSVDB neurons, especially their role in modulating hippocampal activity, remains unknown. We recorded MSVDB neuronal ensembles in behaving rats, and identified a distinct physiologically homogeneous subpopulation of slow-firing neurons (overall firing Ͻ4 Hz) that shared three features: 1) much higher firing rate during rapid eye movement sleep than during slow-wave (SW) sleep; 2) temporary activation associated with transient arousals during SW sleep; 3) brief responses (latency 15ϳ30 ms) to auditory stimuli. Analysis of the fine temporal relationship of their spiking and theta oscillations showed that unlike the theta-pacing neurons, the firing of these "pro-arousal" neurons follows theta oscillations. However, their activity precedes short-term increases in hippocampal oscillation power in the theta and gamma range lasting for a few seconds. Together, these results suggest that these pro-arousal slow-firing MSvDB neurons may function collectively to promote hippocampal activation. medial septum; small-amplitude irregular activity, auditory response; theta oscillations; cholinergic THE MEDIAL SEPTUM-VERTICAL LIMB of the diagonal band of Broca (MSvDB) heavily innervates the hippocampus through cholinergic, GABAergic, and glutamatergic projections (Gritti et al. 2006;Kiss et al. 1990;Kohler et al. 1984;Lewis et al. 1967). These projections are essential for normal hippocampal functions. Lesion or inactivation of MSvDB recapitulates the memory deficit resulting from hippocampal lesions and eliminates hippocampal theta oscillations (Gray and McNaughton 1983;Green and Arduini 1954;Mahut 1972;Mizumori et al. 1990;Winson 1978).To achieve a mechanistic understanding of the critical role of MSvDB in hippocampal functioning, it is essential to elucidate how the neuronal activity in MSvDB modulates hippocampal activity, in particular its dynamic interactions on fine temporal scales. Indeed, this issue has been studied extensively at the electrophysiological level over the last few decades. Those studies have largely focused on the fast-firing, rhythmic-bursting MSvDB neurons and have demonstrated that these cells are the pacemaker of hippocampal theta oscillations (Ford et al. 1989;Hangya et al. 2009;Morales et al. 1971;Petsche et al. 1962).However, in parallel with their heterogeneity in terms of neurotransmitters, the physiological properties of MSvDB neurons are similarly diverse. In addition to the extensively studied fast-firing, rhythmic-bursting neurons, many MSvDB neurons are nonetheless slow-firing and do not fire theta-range rhythmic bursts (Ford et al. 1989;Gaztelu and Buno 1982;Stewart and Fox 1989). As such, these latter cells are unlikely candidates to participate in pacing theta oscillations. The function of these slow-firing neurons remains unknown, in ...

show abstract

“…1966: Buno el al.. 1978] were processed. The rhythmicity coefficient (RC) was calculated as the quotient of the power of the funda mental and the power of all the spectral components in order to quantify rhythmicity [Gaztelu and Buno, 1982). …”

Section: Processingmentioning

confidence: 99%

Electroencephalogram <i>in vitro </i>and Cortical Transmembrane Potentials in the Turtle <i>Chrysemys d'orbigny</i>

Velluti

Russo²,

Símini³

et al. 1991

Brain Behav Evol

View full text Add to dashboard Cite

An experimental stable model of an in vitro turtle brain (Chrysemys d'orbigny) was developed in order to compare electrographic activity (EEG) with transmembrane potentials. Two preparations were used: a whole intact hemisphere and a whole open hemisphere. The latter permitted easier impalement of cortical neurons through the ependymal surface. The EEG characteristics were similar to those described in turtles in vivo. The EEG was nonrhythmic (rhythmicity coefficient <0.40). The power spectrum presented a high energy band between 1 and 3 Hz, decreasing progressively towards the higher frequencies. Total power of the EEG was one order of magnitude greater than the system noise. Random large amplitude sharp waves (22–300 µV, 500–1,900 ms) were recorded spontaneously. Hypoxia produced an increase in frequency and amplitude of the large sharp waves, without modification of either EEG background activity or membrane potentials. Physostigmine provoked the disappearance of the large sharp waves, an effect reversed by atropine. The addition of TTX to the medium provoked the abolition of the EEG, although spikes and plateaus determined by Ca²⁺ conductances persisted. The power spectra band of maximum relative potency was 0.8–2.5 Hz for both EEG and slow membrane potentials.

show abstract

Septo-hippocampal relationship during EEG theta rhythm

Cited by 92 publications

References 22 publications

Cholinergic-Mediated IP₃-Receptor Activation Induces Long-Lasting Synaptic Enhancement in CA1 Pyramidal Neurons

Cholinergic-Mediated IP₃-Receptor Activation Induces Long-Lasting Synaptic Enhancement in CA1 Pyramidal Neurons

A distinctive subpopulation of medial septal slow-firing neurons promote hippocampal activation and theta oscillations

Electroencephalogram <i>in vitro </i>and Cortical Transmembrane Potentials in the Turtle <i>Chrysemys d'orbigny</i>

Contact Info

Product

Resources

About

Septo-hippocampal relationship during EEG theta rhythm

Cited by 92 publications

References 22 publications

Cholinergic-Mediated IP3-Receptor Activation Induces Long-Lasting Synaptic Enhancement in CA1 Pyramidal Neurons

Cholinergic-Mediated IP3-Receptor Activation Induces Long-Lasting Synaptic Enhancement in CA1 Pyramidal Neurons

A distinctive subpopulation of medial septal slow-firing neurons promote hippocampal activation and theta oscillations

Electroencephalogram <i>in vitro </i>and Cortical Transmembrane Potentials in the Turtle <i>Chrysemys d'orbigny</i>

Contact Info

Product

Resources

About

Cholinergic-Mediated IP₃-Receptor Activation Induces Long-Lasting Synaptic Enhancement in CA1 Pyramidal Neurons

Cholinergic-Mediated IP₃-Receptor Activation Induces Long-Lasting Synaptic Enhancement in CA1 Pyramidal Neurons