Septische Enzephalopathie

Terborg, C.

doi:10.1007/s00063-012-0122-1

Cited by 11 publications

(8 citation statements)

References 47 publications

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“…In a study on 5 patients with CNS involvement due to Japanese spotted fever, CT revealed subdural haematoma in 1 of 4 patients and MRI performed on 1 patient was normal 30. Similarly, subtle MRI changes have also been reported in septic encephalopathy, which do not influence in the patient’s management 38. Cranial MRI is also essentially normal in viral infections with systemic manifestation such as dengue and chikungunya 11 39…”

Section: Discussionmentioning

confidence: 99%

Neurological manifestations of scrub typhus

Misra

Mani

2014

J Neurol Neurosurg Psychiatry

100

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Section: Discussionmentioning

confidence: 99%

Neurological manifestations of scrub typhus

Misra

Mani

2014

J Neurol Neurosurg Psychiatry

100

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“…Convulsions is a warning sign of severe/very severe pneumonia which might be related to cerebral ischemia either from hypoxemia or impaired cerebral perfusion secondary to consequence of sepsis [18]. We performed careful neurological examinations, but did not have the facilities for performing EEG.…”

Section: Discussionmentioning

confidence: 99%

Predictors and Outcome of Hypoxemia in Severely Malnourished Children under Five with Pneumonia: A Case Control Design

et al. 2013

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BackgroundThere is lack of information in the medical literature on predictors of hypoxemia in severely malnourished children with pneumonia, although hypoxemia is common and is often associated with fatal outcome in this population. We explored the predictors of hypoxemia in under-five children who were hospitalized for the management of pneumonia and severe acute malnutrition (SAM).MethodsIn this unmatched case-control design, SAM children of both sexes, aged 0–59 months, admitted to the Dhaka Hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) with radiological pneumonia and hypoxemia during April 2011 to April 2012 were studied. SAM children with pneumonia and hypoxemia (SpO2<90%) constituted the cases (n = 37), and randomly selected SAM children with pneumonia but without hypoxemia constituted controls (n = 111).ResultsThe case-fatality was significantly higher among the cases than the controls (30% vs. 4%; p<0.001). In logistic regression analysis, after adjusting for potential confounders such as nasal flaring, head nodding, inability to drink, and crackles in lungs, fast breathing (95% CI = 1.09–13.55), lower chest wall in-drawing (95% CI = 2.48–43.41), and convulsion at admission (95% CI = 3.14–234.01) were identified as independent predictors of hypoxemia in this population. The sensitivity of fast breathing, lower chest wall in-drawing and convulsion at admission and their 95% confidence intervals (CI) to predict hypoxemia were 84 (67–93)%, 89 (74–96)%, and 19 (9–36)% respectively, and their specificity were 53 (43–63)%, 60 (51–69)% and 98 (93–100)% respectively.Conclusion and SignificanceFast breathing and lower chest wall in-drawing were the best predictors of hypoxemia in SAM children with pneumonia. There thus, in resources poor settings where pulse oximetry is not available, identification of these simple clinical predictors of hypoxemia in such children could be reliably used for early O2 supplementation in addition to other appropriate management to reduce morbidity and deaths.

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“…Because of its ease and convenience, computed tomography of the brain is used most often [44], although more information is obtained by cranial magnetic resonance imaging (MRI). MRI is particularly helpful in excluding other diseases.…”

Section: Diagnosis Of Septic Encephalopathymentioning

confidence: 99%

Septic Encephalopathy

Ziaja

2013

Curr Neurol Neurosci Rep

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Every year, more cases of sepsis appear in intensive care units. The most frequent complication of sepsis is septic encephalopathy (SE), which is also the essential determinant of mortality. Despite many years of research, it still is not known at which stage of sepsis the first signs of SE appear; however, it is considered the most frequent form of encephalopathy. Patients have dysfunction of cognitive abilities and consciousness, and sometimes even epileptic seizures. Despite intensive treatment, the effects of SE remain for many years and constitute an important social problem. Numerous studies indicate that changes in the brain involve free radicals, nitric oxide, increased synthesis of inflammatory factors, disturbances in cerebral circulation, microthromboses, and ischemia, which cause considerable neuronal destruction in different areas of the brain. To determine at what point during sepsis the first signs of SE appear, different experimental models are needed to detect the aforementioned changes and to select the proper therapy for this syndrome.

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Septische Enzephalopathie

Cited by 11 publications

References 47 publications

Neurological manifestations of scrub typhus

Neurological manifestations of scrub typhus

Predictors and Outcome of Hypoxemia in Severely Malnourished Children under Five with Pneumonia: A Case Control Design

Septic Encephalopathy

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