Septic shock caused by<i>Elizabethkingia meningoseptica</i>: a case report and review of literature

Jung, Su Hyeon; Lee, Boeun; Mirrakhimov, Aibek E.; Hussain, Nasir

doi:10.1136/bcr-2013-009066

Cited by 12 publications

(11 citation statements)

References 18 publications

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“…Elizabethkingia spp. reportedly causing a variety of diseases, including pneumonia, bacteremia, sepsis, endocarditis, abdominal abscess, sinusitis, bronchitis, epididymitis, and dialysis-related peritonitis in immunocompromised adults [31] and bacterial necrotic inflammation may be a common pathological condition caused by Elizabethkingia spp.…”

Section: Discussionmentioning

confidence: 99%

Candidate Animal Disease Model of Elizabethkingia Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by E. miricola in Pelophylax nigromaculatus

Huang

Feng

Tang

et al. 2019

Oxidative Medicine and Cellular Longevity

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Most species of the genus Elizabethkingia are pathogenic to humans and animals, most commonly causing meningitis. However, our understanding of the pathogenic mechanisms involved is poor and there have been few pathological studies of Elizabethkingia spp. in animals. To understand the host injury induced by Elizabethkingia spp., we established a model of E. miricola infection in the black-spotted frog (Pelophylax nigromaculatus). The systematic pathology in and oxidative damage in the infection model were investigated. Our results show that recently isolated E. miricola is a bacterium that mainly parasitizes the host brain and that neurogenic organs are the predominant sites of damage. Infection mainly manifested as severe brain abscesses, meningoencephalitis, necrotic spondylitis, and necrotic retinitis. The liver, spleen, kidney, gastrointestinal tract, and lung were also affected to varying degrees, with bacterial necrotic inflammation. P. nigromaculatus also suffered enormous damage to its oxidative system during E. miricola infection, which may have further aggravated its disease state. Our results provide a preliminary reference for the study and treatment of Elizabethkingia spp.-induced neurological diseases in animals.

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Section: Discussionmentioning

confidence: 99%

Candidate Animal Disease Model of Elizabethkingia Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by E. miricola in Pelophylax nigromaculatus

Huang

Feng

Tang

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…There are a total of 251 articles on C. indologenes in the National Center for Biotechnology Information database when the widest possible search criteria are used, including articles on bacterial resistance [6] , [7] , pneumonia [8] , [9] , paediatric infections [10] , [11] and CF [4] , [7] . The same occurs in the case of E. meningoseptica, for which the same database lists 1436 published articles concerning contamination of hospital water [12] , [13] , bacteraemia [14] , [15] , [16] and CF [4] , [17] .…”

Section: Introductionmentioning

confidence: 87%

Challenges in the identification of Chryseobacterium indologenes and Elizabethkingia meningoseptica in cases of nosocomial infections and patients with cystic fibrosis

Filho

Marson

Levy

2017

New Microbes and New Infections

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Rare nonfermenting Gram-negative bacilli, such as Chryseobacterium indologenes and Elizabethkingia meningoseptica, have clinical importance in nosocomial infections and cystic fibrosis (CF), and their identification is a challenge to microbiology laboratories. Thus, the objective of this study was to verify the performance of phenotypic and mass spectrometry (matrix-assisted desorption ionization–time of flight mass spectrometry, MALDI-TOF MS) methods to identify C. indologenes and E. meningoseptica. In this context, the results obtained with phenotypic methods—namely manual biochemical and automated VITEK 2 (bioMérieux, Marcy l’Etoile, France) and Phoenix tests (Becton Dickinson (BD), San Diego, CA, USA)—and by MALDI-TOF MS—namely MALDI-TOF VITEK MS (MALDI-MS; bioMérieux) and MALDI-TOF BioTyper (MALDI-BD; BD)—of 22 isolates (blood cultures of patients with nosocomial infection (n = 15) and from patients with CF (n = 7)), initially identified as C. indologenes and E. meningoseptica, were compared. As result, using the manual phenotypic method, it was possible to identify the species level in 18/22; no identification was found in 4/22. There was a low agreement level between manual and VITEK 2 automated phenotypic methods when considering the genus level. The greatest agreement for genus-level identification occurred in MALDI-TOF MS equipment (15/22). When comparing all methods to identify the 22 isolates, there was agreement of 4/22 at the genus level and of 4/22 at the species level. In conclusion, there is low agreement level among identification methods of C. indologenes and E. meningoseptica. Although MALDI-TOF MS equipment shows a higher agreement level among them, results present low levels of confidence.

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“…EM has been found in saline solutions, disinfectants, humidifiers, respirators, and the hands of hospital staff [5]. Colonization of implantable medical devices like intravascular catheters has also been reported and was the most likely cause of infection in the patient of the present case [6].…”

Section: Discussionmentioning

confidence: 73%

Elizabethkingia meningosepticumin a Patient with Six-Year Bilateral Perma-Catheters

Boroda

2014

Case Reports in Infectious Diseases

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Elizabethkingia meningosepticum (EM) is a saprophyte which is ubiquitous in nature, but not normally present in the human flora. Instances of infection are rare in the USA, but EM may be an emerging pathogen among immune-compromised patients. EM can cause a variety of infections, but nosocomial pneumonia and bacteremia have been the most commonly reported among immune-compromised adults. EM has proven difficult to treat with a mortality rate of 23%–41% in adult bacteremia. This is likely due to its resistance to commonly used empiric antibiotics for Gram-negative infections. A review of the literature suggests that there has been a shift EM's susceptibility profile over time along with a great variability in antibiotic susceptibilities reported. This signifies the importance of close monitoring of these changes. In this report we present a case of a 64-year-old male with end stage renal disease and bilateral subclavian perma-catheters, who was admitted with systemic inflammatory response syndrome. While initial peripheral blood cultures were negative, cultures later drawn from his perma-catheters revealed Corneybacterium species and EM. The patient was initially treated with empiric vancomycin and piperacillin-tazobactam. After antibiotics susceptibilities became available, he was treated with levofloxacin and ceftazidime. The patient improved, was culture negative, and later had perma-catheter removal.

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Septic shock caused byElizabethkingia meningoseptica: a case report and review of literature

Cited by 12 publications

References 18 publications

Candidate Animal Disease Model of Elizabethkingia Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by E. miricola in Pelophylax nigromaculatus

Candidate Animal Disease Model of Elizabethkingia Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by E. miricola in Pelophylax nigromaculatus

Challenges in the identification of Chryseobacterium indologenes and Elizabethkingia meningoseptica in cases of nosocomial infections and patients with cystic fibrosis

Elizabethkingia meningosepticumin a Patient with Six-Year Bilateral Perma-Catheters

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