Septic arthritis and osteomyelitis in a 10-year-old boy, caused by Fusobacterium nucleatum, diagnosed with PCR/16S ribosomal bacterial DNA amplification

Infections caused by Fusobacterium in children: a 14-year single-center experience

“…Severe infections caused by Fusobacterium are reported in the head and neck [9,15,16], pulmonary [17], intracranial [18], gastrointestinal [19], osteoarticular [20,21], urogenital [22], in the skin and soft tissue [4] and as neonatal bacteremia [2]. Mild infections, including uncomplicated acute pharyngitis are, however, also reported [23].…”

Fusobacterium nucleatumFacilitates Apoptosis, ROS Generation, and Inflammatory Cytokine Production by Activating AKT/MAPK and NF-κB Signaling Pathways in Human Gingival Fibroblasts

“…F. nucleatum , as a bridging bacterium, transfers critical periodontal pathogens to periodontal infectious sites and recruits and activates local immune cells, which results in tooth-supporting tissue destruction [10, 11]. F. nucleatum has been identified as a high-frequency pathogen in periodontal disease [12] and many other infectious diseases, such as ventriculitis and brain abscesses [13], liver abscesses [14, 15], lung abscesses [16], septicemia-related infections [17], pelvic inflammatory disease [18], and intrauterine infections [19–21]. F. nucleatum attacks host tissues and obstructs the healing of damaged oral tissues by secreting large amounts of ammonia and butyrate [22, 23] and accelerates the initiation and progression of colorectal cancer by promoting tumor cell proliferation [24].…”

Subacute osteomyelitis caused by Fusobacterium nucleatum in a healthy child

“…Osteomyelitis due to F. nucleatum is rare and mostly reported in boys older than 4 years 3–8 . Presentation is generally subacute, with pain progressing over 1–2 weeks, consistent with the low virulence of this organism.…”