Septal Rebound Stretch is a Strong Predictor of Outcome After Cardiac Resynchronization Therapy

Leenders, Geert E.; Boeck, Bart W.L. De; Teske, Arco J.; Meine, Mathias; Bogaard, Margot D.; Prinzen, Frits W.; Doevendans, Pieter A.

doi:10.1016/j.cardfail.2012.02.001

Cited by 46 publications

(64 citation statements)

References 41 publications

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“…Recently, Leenders et al demonstrated that the systolic rebound stretch in the septum, a marker of LV discoordination estimated by speckle-tracking longitudinal strain, was a stronger predictor of long-term prognosis after CRT than other clinical and echocardiographic parameters, including the septal to lateral wall shortening delay. 16 Our result that the SRDI could relate to adverse events after CRT better than the time-delay indices supports their findings.…”

Section: Disclosuressupporting

confidence: 85%

Strain Rate Dispersion Index Can Predict Changes in Left Ventricular Volume and Adverse Cardiac Events Following Cardiac Resynchronization Therapy

Iwano

Yamada

Watanabe

et al. 2013

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp causes dispersion of myocardial shortening and external work, resulting in a reduction in left ventricular (LV) global systolic function. 9-11 Several indices reflecting the wasted contractility by mechanical dyssynchrony have been proposed, 12-16 but have not been widely used in routine clinical practice because they require complex calculation.We recently demonstrated that an index of LV contractility loss because of mechanical dyssynchrony, the strain rate dispersion index (SRDI), better correlated with the changes in global LV systolic function 2 weeks after CRT than did the time-delay indices. 17 However, the efficacy of the SRDI for predicting reductions in both LV volume in the chronic phase and cardiac ardiac resynchronization therapy (CRT) is an established therapy for patients with advanced heart failure (HF) and prolonged QRS duration. 1-3 However, a certain group of patients do not respond favorably to CRT despite having a wide QRS duration. 2,4 One of the reasons for this poor, or lack of, response to CRT has been considered to be the absence of mechanical dyssynchrony, and extensive studies have been performed to identify responders by the use of indices of mechanical dyssynchrony. 5-8 In addition, the amount of wasted contractility because of mechanical dyssynchrony should be also taken into account in the prediction of the response to CRT, because conduction disturbance such as left bundle branch block Background: We previously reported that the strain rate dispersion index (SRDI), an index of left ventricular (LV) contractility loss because of mechanical dyssynchrony, better predicted the acute response to cardiac resynchronization therapy (CRT) than time-delay indices. However, it remains unclear whether the SRDI can predict the chronic response. Additionally, the SRDI needs to be simplified for use in clinical practice.

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Section: Disclosuressupporting

confidence: 85%

Strain Rate Dispersion Index Can Predict Changes in Left Ventricular Volume and Adverse Cardiac Events Following Cardiac Resynchronization Therapy

Iwano

Yamada

Watanabe

et al. 2013

Circ J

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“…Cross-correlation techniques 24 that find similarities between tissue Doppler waveforms and newer quantitative strain indices, septal rebound stretch, 17,25 have also improved prediction of CRT response. These indices indicate that comparing entire waveforms and understanding the underlying pathophysiology are better than a single measurement in predicting outcomes of CRT.…”

Section: Measuring Mechanical Dyssynchrony and Cpdmentioning

confidence: 98%

“…Various clinical and computer models [8][9][10]17 have suggested that such impairment of electrical activation would result in mechanical dyssynchrony characterized by late activation or contraction of the lateral LV wall that terminates (or overpowers) early septal wall contraction, impairing the left ventricle. This dyssynchrony leads to mechanical inefficiency reflected in the discoordination index.…”

Section: Context Of Activation Delays Mechanical Dyssynchrony and Crtmentioning

confidence: 99%

Classic-Pattern Dyssynchrony and Electrical Activation Delays in Pediatric Dilated Cardiomyopathy

Forsha

Slorach

Chen

et al. 2014

Journal of the American Society of Echocardiography

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“…Examples of such indices are the CURE index, 39 internal stretch fraction, 37 systolic dyssynchrony index, 40 and septal rebound stretch. 41,42 So far these indices have only been tested in single-center studies. In direct comparisons, discoordination markers had an area under the curve (AUC) for response that were approximately 0.1 unit higher than dyssynchrony indices.…”

Section: Mechanical Dyssynchrony Versus Mechanical Discoordinationmentioning

confidence: 99%

“…In direct comparisons, discoordination markers had an area under the curve (AUC) for response that were approximately 0.1 unit higher than dyssynchrony indices. 39,41,42 Although promising, these indices of mechanical discoordination have to be validated in prospective multicentre studies yet.…”

Section: Mechanical Dyssynchrony Versus Mechanical Discoordinationmentioning

confidence: 99%

Cardiac Resynchronization Therapy

Prinzen¹,

2013

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Septal Rebound Stretch is a Strong Predictor of Outcome After Cardiac Resynchronization Therapy

Cited by 46 publications

References 41 publications

Strain Rate Dispersion Index Can Predict Changes in Left Ventricular Volume and Adverse Cardiac Events Following Cardiac Resynchronization Therapy

Strain Rate Dispersion Index Can Predict Changes in Left Ventricular Volume and Adverse Cardiac Events Following Cardiac Resynchronization Therapy

Classic-Pattern Dyssynchrony and Electrical Activation Delays in Pediatric Dilated Cardiomyopathy

Cardiac Resynchronization Therapy

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