Sepsis with multiple abscesses caused by staphylococcus warneri: a case report

Ivić, Ivo; Karanović, Jakica; Pavičić-Ivelja, Mirela

doi:10.2478/s11536-012-0066-0

Cited by 15 publications

(10 citation statements)

References 9 publications

(12 reference statements)

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“…Nevertheless, there are some case reports of S. warneri sepsis e.g. in immunocompetent patients with multiple abscesses [21]. It can also cause infections related to community-acquired native valve endocarditis even in patients apparently free from underlying valvular heart disease and haematogenous vertebral osteomyelitis.…”

Section: Introductionmentioning

confidence: 99%

Staphylococcal species less frequently isolated from human clinical specimens - are they a threat for hospital patients?

et al. 2020

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Background: Coagulase-negative staphylococci belonging to S. haemolyticus, S. hominis subsp. hominis, S. simulans, and S. warneri are often described as etiological factors of infections. Staphylococci are a phylogenetically coherent group; nevertheless, there are differences among the species which may be important to clinicians. Methods: We investigated selected virulence factors and antibiotic resistance that were phenotypically demonstrated, the presence and expression of genes encoding the virulence factors, and the type of the SCCmec cassette. Results: The differences between the tested species were revealed. A great number of isolates produced a biofilm and many of them contained single icaADBC operon genes. Clear differences between species in the lipolytic activity spectrum could be related to their ability to cause various types of infections. Our studies also revealed the presence of genes encoding virulence factors homologous to S. aureus in the analysed species such as enterotoxin and pvl genes, which were also expressed in single isolates of S. simulans and S. warneri. S. haemolyticus and S. hominis subsp. hominis isolates were resistant to all clinically important antibiotics including ß-lactams. The identified SCCmec cassettes belonged to IV, V, VII, and IX type but most of the detected cassettes were nontypeable. Among the investigated species, S. hominis subsp. hominis isolates accumulated virulence genes typical for S. aureus in the most efficient way and were widely resistant to antibiotics. Conclusions: Our results clearly indicated significant differences between the tested species, which might be a result of the horizontal gene transfer (HGT) and can lead to the formation and selection of multi-drug resistant strains as well as strains with new virulence features. Such strains can have a new clinical relevance.

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Section: Introductionmentioning

confidence: 99%

Staphylococcal species less frequently isolated from human clinical specimens - are they a threat for hospital patients?

et al. 2020

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“…The second most frequently identified species, S. warneri was isolated from one of the healthcare units and four hospital wards, including cardiology, sickroom of an intensive care unit and an infectious ward, whose patients' immune system may be compromised. This information might be important, as this species was reported to cause infections in hospitalized patients and was also suggested as a cause of, among others, ventricular shunt infections, endocarditis and even sepsis (32,33). One of the most dangerous CoNS, S. haemolyticus was isolated from 4 sites (n = 5) -three hospitals, including the isolation ward of an ICU.…”

Section: Discussionmentioning

confidence: 99%

Assessment of microbiological aerosol concentration in selected healthcare facilities in southern Poland

Stec

Lenart‐Boroń

2019

Cent Eur J Public Health

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Objectives: This study was aimed to assess the concentration of microbial aerosol and species composition of airborne staphylococci in 10 healthcare facilities in southern Poland including primary healthcare units and hospital wards; and to assess whether the selected components of microbial aerosol pose a threat of severe infections to either patients or the personnel. Methods: The study was conducted at monthly intervals over a period of one year. Air samples were collected by MAS-100 sampler. The number of mesophilic bacteria, mould fungi, actinomycetes and staphylococci was determined on general and selective media. The species identification of staphylococci was conducted using API tests for strains that were pre-selected based on macroscopic and microscopic observations. Results: A total number of 1,584 samples were collected during the sampling period. The numbers of airborne microorganisms varied between the examined premises and between the seasons of the year. The observed differences were statistically significant with one exception for actinomycetes and their differences between the examined premises. The concentrations of mesophilic bacteria varied from 5 to 297 CFU/m 3 of air, for Staphylococcus the values ranged from 1 to 96 CFU/m 3 , for fungi-from 1 to 100 CFU/m 3 , and the number of actinomycetes ranged from 7 to 321 CFU/m 3. Ten species of coagulase-negative staphylococci (CoNS) were identified among 55 isolates with S. saprophyticus and S. warneri being the most frequently detected (n = 14 and 13, respectively). S. haemolyticus, which is one of the most common causal agents of nosocomial infections was observed in four facilities (n = 5). Conclusions: The microbial concentrations varied both between the seasons of the year and between the examined facilities. The highest bioaerosol concentrations were observed in most crowded premises. The identified species of staphylococci, although not typically associated with human infections, are common causal agents of nosocomial infections and infections in immunocompromised people.

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“…[17][18][19] S. warneri are isolated rarely from patients with artificial heart valves, cerebrospinal fluid derivation shunts, intravascular catheters, similar to the other representatives of CoNS, but some cases of sepsis in immune-competent patients with lack of risk factors have been reported. 2 The first case of S. warneri isolated from sturgeons with sepsis has been reported by Bulgarian authors. 20 Another rare pathogen that can be isolated from patients with risk factors is S. capitis.…”

Section: Discussionmentioning

confidence: 99%

“…Methicillin resistant Staphylococcus aureus (MRSA) and methicillin resistant coagulase-negative staphylococci (MRCoNS), except when the latter are contaminants, are the major causes of life-threatening bloodstream infections (BSI), endocarditis, postoperative soft tissue infections, osteomyelitis, septic arthritis, metastatic abscesses, especially nosocomial ones, and pose a global problem for public health. [1][2][3] The virulence arsenal of staphylococcal isolates differs depending on the bacterial species and the coagulase-positive S. aureus has been proved to be the most virulent species. The most frequent severe BSI infections caused by this pathogen are due to various extracellular products, e.g.…”

Section: Introductionmentioning

confidence: 99%

Molecular-genetic Method for Fast Direct Detection of Staphylococcus Aureus and Methicillin Resistance in Blood Cultures and Punctures

Gergova

Tsitou

Mitov

2019

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Citation: Gergova RT, Tsitou VMS, Mitov IG. Molecular-genetic method for fast direct detection of Staphylococcus aureus and methicillin resistance in blood cultures and punctures. Folia Med (Plovdiv) 2019;61(4):559-65. AbstractBackground: Invasive infections caused by methicillin resistant Staphylococcus aureus and coagulase-negative staphylococci (MRSA/ MRSCoN) require fast, adequate treatment.The aim of this study was to develop a faster protocol for direct detection of MRSA/MRSCoN in blood cultures and in abscess punctures based on mecA and species specific identification of S. aureus by polymerase-chain reaction (PCR). Materials and methods:We examined 77 growth-positive BACTEC blood cultures and 50 abscess punctures by routine microbiological assay and simultaneous PCR detection of MRSA/MRSCoN. The specificity of the PCR was evaluated by using DNA from another 15 microbial species for negative controls. We determined the minimum inhibitory concentration (MIC) of oxacillin, vancomycin, tigecycline, linezolid, levofloxacin, clindamycin, and erythromycin against the S. aureus isolates using the E-test. Results:In the blood cultures, the two methods detected 39.3% of MRSA, and 93.9% of MRCoNS. In the punctures, the PCR assay identified 20.9% of MRSA and 79.2% of MSSA. In the puncture cases, there were three PCR MRSA positive and culture negative samples. Screening for susceptibility to 14 antimicrobial agents demonstrated significantly higher (p<0.05) methicillin resistance in blood culture isolates than in the puncture ones (39.3% and 20.0%, respectively). Conclusion:The new PCR protocol was very fast and specific. It was more sensitive in detecting MRSA from abscess punctures than the routine microbiological techniques. This protocol will speed up the right choice of empirical therapy, which is extremely important for saving patients' lives.

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Sepsis with multiple abscesses caused by staphylococcus warneri: a case report

Cited by 15 publications

References 9 publications

Staphylococcal species less frequently isolated from human clinical specimens - are they a threat for hospital patients?

Staphylococcal species less frequently isolated from human clinical specimens - are they a threat for hospital patients?

Assessment of microbiological aerosol concentration in selected healthcare facilities in southern Poland

Molecular-genetic Method for Fast Direct Detection of Staphylococcus Aureus and Methicillin Resistance in Blood Cultures and Punctures

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