Sepsis neonatal por anaerobios Bacteroides capillosus

Structural and Kinetic Properties of a β-Hydroxyacid Dehydrogenase Involved in Nicotinate Fermentation

“…The latter two organisms are clinically relevant as A. colihominis is an isolate from the blood of a patient with nosocomial bacteraemia, 4 while B. capillosus, a normal resident of the human gut, can cause neonatal sepsis and can be associated with cysts and wounds. 5 According to sequence homology, Hgd belongs to the 3-hydroxyisobutyrate dehydrogenase (3-HIBADH)/ 6-phosphogluconate dehydrogenase (6-PGDH) superfamily. 6 This class of dehydrogenases acts on the common 3-hydroxypropionate moiety of their substrates (Fig.…”