Sepsis-Induced Acute Kidney Injury

Mårtensson, Jerker; Bellomo, Rinaldo

doi:10.1016/j.ccc.2015.06.003

Cited by 73 publications

(44 citation statements)

References 68 publications

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“…The tissue shows glomerulus contraction and dilatation, and edema in renal tubular epithelial and interstitial tissues. The BUN and Cr levels in serum are increased, suggesting kidney dysfunction [28]. In the present study, miR-138 was responsible for the tissue damage and organ dysfunction induced by LPS.…”

Section: Discussionmentioning

confidence: 66%

MicroRNA-138 Aggravates Inflammatory Responses of Macrophages by Targeting SIRT1 and Regulating the NF-κB and AKT Pathways

Bai

Zhang

Yang

et al. 2018

Cell Physiol Biochem

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Background/Aims: With increased understanding of sepsis, mortality is decreasing. However, there is still a lack of effective therapeutic strategy. The inflammatory response of macrophages is critical during sepsis. Methods: Macrophages were stimulated with LPS. Western blotting and qRT-PCR were used to detect inflammatory responses. Then, the inhibitor of microRNA-138 was transfected and Western blotting, qRT-PCR, H&E staining and ELISA were used to verify the role of microRNA-138 in inflammation. Then target gene prediction databases were used to predict the potential target of microRNA-138. Both animal and cell models under LPS challenges were established to verify the regulation of SIRT1 and microRNA-138 during inflammation. Results: The present study showed that microRNA-138 was increased in macrophages stimulated with LPS. Additionally, the NF-κB and AKT pathways were both activated. The pre-treatment of microRNA-138 inhibitor decreased inflammatory factors, downregulated the NF-κB pathway, activated the AKT pathway and protected against organ damage in mice challenged with LPS. SIRT1 was demonstrated as a potential target of microRNA-138In macrophages stimulated with LPS, the inhibition effect of microRNA-138 inhibitor on inflammation was lost by SIRT1 siRNA pre-treatment. In the animal model, the protective effect of microRNA-138 antagomir disappeared in SIRT1 knockout mice. Conclusion: We demonstrated that miR-138 participated in the inflammatory process by inhibiting SIRT1 and activating the NF-κB pathway.

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Section: Discussionmentioning

confidence: 66%

MicroRNA-138 Aggravates Inflammatory Responses of Macrophages by Targeting SIRT1 and Regulating the NF-κB and AKT Pathways

Bai

Zhang

Yang

et al. 2018

Cell Physiol Biochem

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“…Acute kidney injury of various aetiologies is an important public health issue worldwide. 3 Based on various epidemiological studies, 20% of individuals undergoing elective cardiovascular (CV) surgery or intervention may develop AKI. 4,5 Post-operative AKI has important implications relating to subsequent mortality, morbidity, and cost.…”

Section: Introductionmentioning

confidence: 99%

Endovascular aneurysm repair (EVAR)– and transcatheter aortic valve replacement (TAVR)–associated acute kidney injury

Jhaveri

Saratzis

Wanchoo

et al. 2017

Kidney International

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“…[27,28] As sepsis was a frequent complication of patient with ECF, there would be a large portion of ECF patients accompanied with AKI. These had been studied that clinical bleeding was a major manifestation of renal failure in the predialysis era.…”

Section: Discussionmentioning

confidence: 99%

Risk factor and outcome for intra-abdominal bleeding in patients with enterocutaneous fistula

Ren²,

Liu³

et al. 2016

Medicine

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Intra-abdominal bleeding is a major and lethal complication in patients with enterocutaneous fistula (ECF) while few studies are involved in this aspect. In the present study, we aimed to investigate the risk factors and assessed the outcome for intra-abdominal bleeding in patients with ECF.A retrospective study was performed from October 2013 to October 2015. Medical records of 67 ECF patients with intra-abdominal bleeding and 134 ECF patients without intra-abdominal bleeding matched as controls were reviewed and analyzed. Logistic regression was performed to evaluate the risk factor of intra-abdominal bleeding in patients with ECF. Outcomes such as mortality, hospital durations, and cost were compared between ECF patients with or without intra-abdominal bleeding.A total of 67 ECF patients suffered intra-abdominal bleeding during hospitalization. In the logistic regression, duodenum fistula (odds ratio [OR]: 3.899, 95% confidence interval [CI]: 1.204–12.634, P = 0.023), hemorrhage history (OR: 15.846 95% CI: 5.779–43.448, P < 0.001), and acute kidney injury (OR: 6.350 95% CI: 2.033–19.836, P = 0.001) were independent risk factors for intra-abdominal bleeding in patients with ECF. In addition, the bleeding patients showed a significantly higher mortality rate, prolonged total parenteral nutrition days, hospital and intensive care unit durations, more complications, and increased cost.We revealed the 3 risk factors for intra-abdominal bleeding among ECF patients. Besides, intra-abdominal hemorrhage was associated with a poor prognosis in patients with ECF.

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Sepsis-Induced Acute Kidney Injury

Cited by 73 publications

References 68 publications

MicroRNA-138 Aggravates Inflammatory Responses of Macrophages by Targeting SIRT1 and Regulating the NF-κB and AKT Pathways

MicroRNA-138 Aggravates Inflammatory Responses of Macrophages by Targeting SIRT1 and Regulating the NF-κB and AKT Pathways

Endovascular aneurysm repair (EVAR)– and transcatheter aortic valve replacement (TAVR)–associated acute kidney injury

Risk factor and outcome for intra-abdominal bleeding in patients with enterocutaneous fistula

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