Sepsis in Africa: practical steps to stem the tide

Otu, Akaninyene; Elston, James; Nsutebu, Emmanuel

doi:10.11604/pamj.2015.21.323.6462

Cited by 18 publications

(18 citation statements)

References 5 publications

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“…About 568 articles were removed by screening using their titles and abstracts. Three articles were excluded after using full-text review with the reason that the outcomes of the articles were not clear for researchers [10, 45, 46]. Finally, 36 articles fit with our study objectives (Fig.…”

Section: Resultsmentioning

confidence: 99%

Unfinished agenda of the neonates in developing countries: magnitude of neonatal sepsis: systematic review and meta-analysis

Amare

Mela

Dessie

2019

Heliyon

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PurposeNeonatal sepsis is the major cause of mortality and morbidity globally, particularly in developing countries. Despite studies revealed the extent of neonatal sepsis in developing countries, the findings were inconclusive. Therefore, the main aim of this study was to determine the pooled prevalence of neonatal sepsis in developing countries.MethodsWe used a systematic review and Meta-analysis study method. The reviewed studies were accessed through an electronic web-based search strategy from the electronic database (PUBMED), advanced google scholar, different journal sites. The data extraction was done by two researchers using a data extraction table and the disparity between data extractors was resolved by the third researcher. The analysis was done using STATA version 11. The I2 test was used to assess heterogeneity across studies. The Funnel plot, Begg's test, and Egger's test were used to check for publication bias. The random-effect model was used to determine the pooled effect size. All studies related to neonatal sepsis which fulfill the inclusion criteria were considered into this study. The quality of each study was checked using the Newcastle-Ottawa Scale and studies graded low score were excluded from the study.ResultsAt the end, 36 articles fit with our study objectives. Studies conducted in Ethiopia were significant the source of heterogeneity of the study with a coefficient = 90, P-value = 0.025. The overall pooled prevalence of the study was 29.92%. The limitations of this study would be the authors were only used articles reported in the English language, and publication bias.ConclusionThe pooled prevalence of neonatal sepsis was found to be high which accounted for a third of the neonates. Despite countries have established possible prevention and treatment mechanisms, neonatal sepsis is the major public health problem in lower and middle-income countries till now.

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Section: Resultsmentioning

confidence: 99%

Unfinished agenda of the neonates in developing countries: magnitude of neonatal sepsis: systematic review and meta-analysis

Amare

Mela

Dessie

2019

Heliyon

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“…The 116 articles had a median Web of Science citations was 5 (IQR: 3-12) on and 5 (IQR: 3-13) median citations when considering additional citation sources (BIOSIS, Chinese Science Citation, Data Citation, Russian Science, and SCIELO). The median usage count (since 2013) was 2 (IQR: 1-4), and the articles had a median of 23 (IQR: [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] references.…”

Section: Resultsmentioning

confidence: 99%

Systematic review and bibliometric analysis of African anesthesia and critical care medicine research Part II: A scientometric analysis of the 116 most cited articles

Kanmounye

Tochie

Mbonda

et al. 2020

Preprint

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BackgroundScientometrics is used to assess the impact of research in several health fields, including Anesthesia and Critical Care Medicine. The purpose of this study was to define the landscape and key players of Anesthesia and Critical Care Medicine research in Africa.MethodsThe authors searched Web of Science from inception to May 4, 2020, for articles on and about Anesthesia and Critical Care Medicine in Africa with ≥ 2 citations. Quantitative (H-index) and qualitative (descriptive analysis of yearly publications and interpretation of document, co-authorship, author country, and keyword) bibliometric analyses were done.ResultsThe search strategy returned 116 articles that had a median of 5 (IQR: 3-12) citations on Web of Science. The most frequent journals were Anesthesia and Analgesia (18, 15.5%), World Journal of Surgery (13, 11.2%), and South African Medical Journal (8, 6.9%). Most (74, 63.8%) articles were published on or after 2013, and seven authors had more than 1 article in the top 116 articles: Epiu I (3, 2.6%), Elobu AE (2, 1.7%), Fenton PM (2, 1.7%), Kibwana S (2, 1.7%), Rukewe A (2, 1.7%), Sama HD (2, 1.7%), and Zoumenou E (2, 1.7%). The bibliometric coupling analysis of documents highlighted 10 clusters with the most significant nodes being Biccard BM, 2018; Baker T, 2013; Llewellyn RL, 2009; Nigussie S, 2014; and Aziato L, 2015. Dubowitz G (5) and Ozgediz D (4) had the highest H-indices among the authors referenced by the most-cited African Anesthesia and Critical Care Medicine articles. The U.S.A. had the largest global node, while South Africa and Uganda had the largest African nodes. The most prominent keywords were anesthesia, mortality, and surgery. ConclusionThis study highlighted a decline in the number of top-cited African articles and the roles of the U.S.A, Southern African, and East African countries in scholarly output. Future studies should focus on understanding the time trends of the publications.

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“…We found that only about fifty percent of the hospitals have laboratory services for 24 h for basic laboratory tests as full blood count, basic metabolic profile, blood, and urine cultures. This is a perennial issue in African countries, where the availability, accessibility, and affordability of blood culture is a common problem (28). Only 2% of the hospitals surveyed in Nigeria do have the capacity to measure any serum markers like serum lactate.…”

Section: Discussionmentioning

confidence: 99%

A National Survey of Resources to Address Sepsis in Children in Tertiary Care Centers in Nigeria

et al. 2019

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Background: Infections leading to sepsis are major contributors to mortality and morbidity in children world-wide. Determining the capacity of pediatric hospitals in Nigeria to manage sepsis establishes an important baseline for quality-improvement interventions and resource allocations. Objectives: To assess the availability and functionality of resources and manpower for early detection and prompt management of sepsis in children at tertiary pediatric centers in Nigeria. Methods: This was an online survey of tertiary pediatric hospitals in Nigeria using a modified survey tool designed by the World Federation of Pediatric Intensive and Critical Care Societies (WFPICCS). The survey addressed all aspects of pediatric sepsis identification, management, barriers and readiness. Results: While majority of the hospitals 97% (28/29) reported having adequate triage systems, only 60% (16/27) follow some form of guideline for sepsis management. There was no consensus national guideline for management of pediatric sepsis. Over 50% of the respondents identified deficit in parental education, poor access to healthcare services, failure to diagnose sepsis at referring institutions, lack of medical equipment and lack of a definitive protocol for managing pediatric sepsis, as significant barriers. Conclusions: Certain sepsis-related interventions were reportedly widespread, however, there is no standardized sepsis protocol, and majority of the hospitals do not have pediatric intensive care units (PICU). These findings could guide quality improvement measures at institutional level, and healthcare policy/spending at the national level.

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Sepsis in Africa: practical steps to stem the tide

Cited by 18 publications

References 5 publications

Unfinished agenda of the neonates in developing countries: magnitude of neonatal sepsis: systematic review and meta-analysis

Unfinished agenda of the neonates in developing countries: magnitude of neonatal sepsis: systematic review and meta-analysis

Systematic review and bibliometric analysis of African anesthesia and critical care medicine research Part II: A scientometric analysis of the 116 most cited articles

A National Survey of Resources to Address Sepsis in Children in Tertiary Care Centers in Nigeria

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