Sepsis, Glucose Intolerance, and Protein Malnutrition

Dahn, Michael S.

doi:10.1001/archsurg.1980.01380120003001

Cited by 27 publications

(1 citation statement)

References 14 publications

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“…":" The provision of greater than 1.5 g/kg/day of protein results in no greater protein sparinq. ": 12 The concomitant presence of hyperglycemia and often, organ disease in the traumatically injured individual further complicates aggressive intervention." Administration of lipid calories such as w6 polyunsaturated fatty acids is becoming increasingly controversial in light of continued evidence of their detrimental effects on the immune response.…”

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confidence: 99%

Growth Factors in Nutritional Support

Hatton,

Luer,

Rapp

1993

Pharmacotherapy

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Protein catabolism occurs in the severely stressed patient despite adequate protein supplementation. Supplementation of endogenous growth factors is one mechanism being evaluated to promote anabolism and improve nitrogen retention. Recombinant technology has provided a means to reproduce these endogenous growth factors. Both recombinant human growth hormone (rGH) and recombinant human insulin‐like growth factor‐1 (rhIGf‐1) are undergoing clinical trials to establish their roles in nutritional support.

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confidence: 99%

Growth Factors in Nutritional Support

Hatton,

Luer,

Rapp

1993

Pharmacotherapy

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The effect of sepsis on the oxidation of carbohydrate and fat

Stoner

Little

Frayn

et al. 1983

Journal of British Surgery

134

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Oxidative metabolism has been studied by indirect calorimetry in 27 patients with sepsis and in 7 non-septic patients while they were all receiving total parenteral nutrition. Glucose oxidation was reduced in the septic patients and fat oxidation continued despite the infusion of an excess of glucose. The extent of these changes depended on the severity of the septic state as measured by the scoring system described in the preceding paper. The mechanism of these changes is not known. They were not related to an elevation of the plasma nonesterified fatty acid concentration. Alterations must have occurred in the way fat was taken up and metabolized by the cells. Here insulin resistance and the highly significant positive relationship found between the plasma cortisol concentration and the sepsis score might be important.

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Substrate Handling in the Stress-Induced Catabolic State — Where is the Challenge?

Mjaaland¹

1996

Acute Catabolic State

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Sepsis, Glucose Intolerance, and Protein Malnutrition

Cited by 27 publications

References 14 publications

Growth Factors in Nutritional Support

Growth Factors in Nutritional Support

The effect of sepsis on the oxidation of carbohydrate and fat

Substrate Handling in the Stress-Induced Catabolic State — Where is the Challenge?

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