Sepsis and Coronavirus Disease 2019: Common Features and Anti-Inflammatory Therapeutic Approaches

Beltrán-García, Jesús; Osca-Verdegal, Rebeca; Pallardó, Federico V.; Ferreres, José; Rodríguez, M. Andrea; Mulet, Sandra; Ferrando-Sánchez, Carolina; Carbonell, Nieves; García‐Giménez, José Luis

doi:10.1097/ccm.0000000000004625

Cited by 91 publications

(80 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…COVID-19 can present as sepsis hence precautionary isolation measures were taken against him, as RT-PCR test results were unavailable. 9 …”

Section: Discussionmentioning

confidence: 99%

Perioperative challenges in managing a patient with COVID-19 undergoing debridement for massive scalp myiasis

Teah

et al. 2021

BMJ Case Rep

View full text Add to dashboard Cite

A young man presented to our centre needing an urgent debridement of his postcraniotomy wound due to massive myiasis during the COVID-19 pandemic in October 2020. Prior to the surgery, his nasopharyngeal swab real-time PCR test result was unknown. One day later, it returned as SARS-CoV-2 positive. All healthcare workers who were involved in the patient management avoided cross infection as they wore appropriate personal protective equipment. This article depicts the importance of adequate preparations when handling potentially infectious patients and the perioperative issues associated with it.

show abstract

“…COVID-19 can present as sepsis hence precautionary isolation measures were taken against him, as RT-PCR test results were unavailable. 9 …”

Section: Discussionmentioning

confidence: 99%

Perioperative challenges in managing a patient with COVID-19 undergoing debridement for massive scalp myiasis

Teah

et al. 2021

BMJ Case Rep

View full text Add to dashboard Cite

show abstract

“…Possible causes include a direct attack of the virus on the endothelial cells via ACE-2 receptors, cytokine storm, or activation of the coagulation system. Surprisingly, disseminated intravascular coagulation has also been reported in patients with COVID-19 [ 78 ]. However, DIC associated with COVID-19 has a different pathophysiology than that of septic DIC.…”

Section: Final Remarks On Covid-19 and Sepsismentioning

confidence: 99%

“…However, DIC associated with COVID-19 has a different pathophysiology than that of septic DIC. The COVID-19-associated DIC is characterized by an enhanced fibrinolytic system, whereas septic DIC is a DIC with suppressed fibrinolysis [ 78 ]. Thus, coagulopathies accompanying severe COVID-19 can cause thromboembolism, but can also go to the other extreme of inducing DIC with a different underlying mechanism than that of sepsis.…”

Section: Final Remarks On Covid-19 and Sepsismentioning

confidence: 99%

Severe COVID-19 and Sepsis: Immune Pathogenesis and Laboratory Markers

2021

View full text Add to dashboard Cite

The ongoing outbreak of the novel coronavirus disease 2019 (COVID-19), induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has taken a significant toll on people and countries all over the world. The pathogenesis of COVID-19 has not been completely elucidated yet. This includes the interplay between inflammation and coagulation which needs further investigation. The massive production of proinflammatory cytokines and chemokines results in the so-called cytokine storm, leading to plasma leakage, vascular hyperpermeability, and disseminated vascular coagulation. This is usually accompanied by multiorgan failure. The extensive changes in the serum levels of cytokines are thought to play a crucial role in the COVID-19 pathogenesis. Additionally, the viral load and host inflammation factors are believed to have a significant role in host damage, particularly lung damage, from SARS-CoV-2. Interestingly, patients exhibit quantitative and qualitative differences in their immune responses to the virus, which can impact the clinical manifestation and outcomes of COVID-19. There needs to be a better understanding of the dynamic events that involve immune responses, inflammatory reactions, and viral replication in the context of the COVID-19 infection. Here, we discuss the main aspects of COVID-19 pathogenesis while supporting the hypothesis that inflammatory immune responses are involved in the progression of the disease to a more critical and fatal phase. We also explore the similarities and differences between severe COVID-19 and sepsis. A deeper understanding of the COVID-19 clinical picture as it relates to better-known conditions such as sepsis can provide useful clues for the management, prevention, and therapy of the disease.

show abstract

“…Indeed, sepsis-associated ABD is highlighted in the current COVID-19 pandemic trends [56][57][58][59][60][61]. According to the clinical criteria of Sepsis-3, i.e., quick Sequential (sepsis-related) Organ Function Assessment (qSOFA: range, 0 -3 points, with 1 point each for tachypnea (≥ 22/min), altered mentation, or systolic hypotension (≤ 100 mm Hg), if ≥ 2 points indicates sepsis) [3], most severe COVID-19-associated ARDS and altered mentation have fully met the diagnose of sepsis [4,7,13,[62][63][64]. Moreover, the ARDS play pivotal roles in the development of multiple organ dysfunction syndrome (MODS) in septic event [65,66].…”

Section: Sepsis Is Related To Severe Covid-19-associated Abdmentioning

confidence: 99%

COVID-19-Associated Acute Brain Dysfunction Related to Sepsis

2021

View full text Add to dashboard Cite

In global term, as of November 30, 2020, over 30 million people has been infected by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more than 10,000,000 of them died of acute organ failure. Our reviews have shown that coronavirus disease 2019 (COVID-19) patients with pneumonia and acute respiratory distress syndrome (ARDS) have life-threatening acute brain dysfunction (ABD), ranging from altered mental status/delirium to stupor/coma. Altered mental status/delirium was the most common manifestation of ABD caused by severe COVID-19. The prevalence of altered mental status and/or delirium was up to 66-79.5%, and prevalence of coma was 10%. The most common clinical type of COVID-19-associated ABD was COVID-19-associated acute stroke including ischemic and hemorrhagic stroke (n > 350 cases), followed by COVID-19-associated encephalopathy (n > 200 cases), and COVID-19-associated central nervous system (CNS) infection (n > 70 cases). According to the Sepsis-3 criteria, we confess that severe COVID-19-associated ABD with ARDS and altered mental status is related to sepsis. Moreover, we also review the diagnosis and treatment of COVID-19-associated ABD with sepsis. In view of the fact that COVID-19 is at the peak of epidemic worldwide, we hope that this review will provide evidence of COVID-19 sepsis threating to the brain dysunction. Thus, recognizing the COVID-19-associated ABD related to sepsis is very important for early empirical combination therapy to survive severe COVID-19.

show abstract

Sepsis and Coronavirus Disease 2019: Common Features and Anti-Inflammatory Therapeutic Approaches

Cited by 91 publications

References 41 publications

Perioperative challenges in managing a patient with COVID-19 undergoing debridement for massive scalp myiasis

Perioperative challenges in managing a patient with COVID-19 undergoing debridement for massive scalp myiasis

Severe COVID-19 and Sepsis: Immune Pathogenesis and Laboratory Markers

COVID-19-Associated Acute Brain Dysfunction Related to Sepsis

Contact Info

Product

Resources

About