Sepsis and antimicrobial stewardship: two sides of the same coin

Fitzpatrick, Fidelma; Tarrant, Carolyn; Hamilton, Vida; Kiernan, Fiona; Jenkins, David R.; Krockow, Eva M.

doi:10.1136/bmjqs-2019-009445

Cited by 51 publications

(42 citation statements)

References 19 publications

(15 reference statements)

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“…In the face of a growing burden of antimicrobial resistance and antibiotic-associated infections such as Clostridioides difficile infection, a greater alignment between antimicrobial stewardship and sepsis prevention and treatment programmes is essential. 47 Complementary strategies such as de-escalation protocols and prompt discontinuation of antibiotics when no longer indicated should be incorporated into sepsis quality improvement initiatives. Little is known about antimicrobial resistance in maternity units globally 48 and this information is essential to guide policy on the safe administration of prophylactic antibiotics during childbirth.…”

Section: Ensure Laboratory Diagnostics For Sepsis Are Affordable and mentioning

confidence: 99%

How to close the maternal and neonatal sepsis gap in sub-Saharan Africa

et al. 2020

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Section: Ensure Laboratory Diagnostics For Sepsis Are Affordable and mentioning

confidence: 99%

How to close the maternal and neonatal sepsis gap in sub-Saharan Africa

et al. 2020

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“…This information on sepsis bundle compliance will help improve sepsis management. While the Surviving Sepsis bundle emphasizes the timely administration of broad-spectrum antibiotics to cover possible causative pathogens, this approach may adversely increase the use of broad-spectrum antibiotics and thus the risk of multidrug-resistant pathogens [18]. Therefore, the appropriateness of antimicrobial treatment and antibiotic stewardship in the treatment of sepsis will be assessed.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the appropriateness of antimicrobial treatment and antibiotic stewardship in the treatment of sepsis will be assessed. Re-evaluation and de-escalation by antibiotic stewardship are the critical aspects of sepsis management and need to be integrated, along with the sepsis bundle, to improve the quality and outcomes of sepsis management [18]. In Europe (Ireland and United Kingdom), to address this issue, goals and effectiveness of antibiotic stewardship efforts have been made integral parts of sepsis management [19,20].…”

Section: Discussionmentioning

confidence: 99%

Korean Registry for Improving Sepsis Survival (KISS): Protocol for a Multicenter Cohort of Adult Patients with Sepsis or Septic Shock

Kim

et al. 2020

Infect Chemother

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Sepsis is one of the significant causes of morbidity and mortality. The burden caused by sepsis has continued to increase in recent years in the Korea, highlighting the urgent need for the implementation of strategies to improve sepsis treatment outcomes. We therefore designed a web-based sepsis registry system ("Korean Registry for Improving Sepsis Survival" [KISS]) protocol to be used in hospitals in the Korea for evaluation of the epidemiology and clinical characteristics of patients with sepsis, via an analysis of outcome predictors. The inclusion criteria of this registry are as follows: adult patients ≥18 years admitted to the participating hospitals who are diagnosed with sepsis or septic shock. Demographic and clinical information data of the patients will be collected from hospital medical records and will be recorded in a case report form, which will be entered into a web-based data management system. The analysis of the collected data will be performed as follows: (1) epidemiological and clinical characteristics of sepsis and septic shock, (2) application of sepsis bundles and antibiotic stewardship, and (3) audit and feedback. In conclusion, we aim to build the comprehensive web-based sepsis registry in the Korea through a nationwide network of participating hospitals. Information collected and analyzed through the KISS can be used for further improvements in the clinical management of sepsis. Furthermore, the KISS will facilitate research leading to the formulation of public health policies regarding sepsis bundle and antibiotic stewardship strategies in the Korea.

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“…These competing considerations must be addressed together, even in life‐critical conditions like sepsis doctors (and vets) should objectively appraise their patient to reach an evidence‐based decision to use or withhold antibiotics without forgetting that inappropriate prescription represents both a public health threat and a patient safety issue (Fitzpatrick et al . ).…”

Section: Introductionmentioning

confidence: 97%

“…However, overdiagnosis and overtreatment pose their own set of dangers including the risk of adverse effects -including hospital-acquired MDR infections (including Clostridioides difficile) and the potential exacerbation of AMR. These competing considerations must be addressed together, even in life-critical conditions like sepsis doctors (and vets) should objectively appraise their patient to reach an evidence-based decision to use or withhold antibiotics without forgetting that inappropriate prescription represents both a public health threat and a patient safety issue (Fitzpatrick et al 2019).…”

Section: Introductionmentioning

confidence: 99%