Sepsis 2016 Agra, India

Sharma, Surinder K.; Rohatgi, Anurag; Bajaj, Mansi; Sprung, Charles L.; Morales, Ricardo; Kasdan, Harvey L.; Reiter, A; Volker, T.; Meissonnier, Julien; Белобородова, Н. В.; Мороз, В. В.; Bedova, Aleksandra; Sarshor, Yu. N.; Осипов, А. А.; Chernevskaya, Katerina; Федотчева, Н. И.; Chernevskaya, Ekaterina; Imahase, Hisashi; Yamada, Kosuke; Sakamoto, Yuichiro; Ohta, Miho; Sakurai, Ryota; Yahata, Mayuko; Umeka, Mitsuru; Miike, Toru; Koami, Hiroyuki; Nagashima, Futoshi; Iwamura, Takashi; Inoue, Satoshi; Li, Zhifeng; Grech, Dennis; Morcillo, Patrick; Bekker, Alex; Ulloa, Luis; Mukhopadhyay, Samanwoy; Pandey, AK; Bhattacharjee, Samsiddhi; Mohapatra, Saroj Kant; Wilson, Julie K.; Jadhav, Savita; Misra, Rabindra Nath; Gandham, Nageswari; Angadi, Kalpana; Vywahare, Chanda; Gupta, Neetu; Desai, Deepali; Bakochi, Anahita; Mohanty, Tirthankar; Linder, Adam; Malmström, Johan; Anand, Dimple; Bhargava, Seema; Srivastava, Lalit M.; Ray, Sumit; Fisher, Jane; Bentzer, Peter; Costa, Luís Henrique Angenendt da; Júnior, Nilton Nascimentos dos Santos; Catalão, Carlos Henrique Rocha; Rocha, Maria José Alves da; Focà, Alfredo; Peronace, Cinzia; Matera, Giovanni; Giancotti, Aida; Barreca, Giorgio Settimo; Quirino, Angela; Loria, Maria Teresa; Settembre, Pio; Liberto, Maria Carla; Amantea, B; Hartog, Christiane S.; Moeller, Claudia; Fleischmann, Carolin; Thomas-Rueddel, D.; Vlasakov, Vlasislav; Rochwerg, Bram; Theurer, Philip; Reinhart, Konrad; Smith, Anna E.; Taylor, Sandra; Costa, Christopher da; Radford, Amanda; Lee, Terry; Singer, Joel; Boyd, John H.; Fineberg, David; Williams, Mark; Russell, James A.

doi:10.1186/s13054-016-1204-x

Cited by 3 publications

(2 citation statements)

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“…These substances affect the functions of mitochondria by producing active oxygen species, decreasing the rate of oxidation of NADdependent substrates [9], and suppressing the phagocyte activity of neutrophils in vitro [10]. The effects observed in vitro caused by the action of the AMM were similar to those in septic patients, and an increase in the concentration of these metabolites has been proposed as one of the causes of mitochondrial dysfunction in sepsis [11]. The following AMM are potentially involved in the pathological process: phenyllactic acid (PhLA), phenylpropionic acid (PhPA), phenylacetic acid (PhAA), p-hydroxyphenylacetic acid (p-HPhAA), and p-hydroxyphenyllactic (p-HPhLA) acid.…”

Section: Introductionmentioning

confidence: 99%

Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study

et al. 2020

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Background: High serum levels of certain aromatic microbial metabolites (AMM) are associated with severity and mortality in critically ill patients. Omics-based studies suggest gut dysbiosis and reduced microbiome diversity in critical conditions. However, the landscape of gut microbial metabolites is still to be outlined, not to mention the interplay correlation between the metabolome and gut microbiome in critically ill patients. The aim of this study was to analyze the association between serum and fecal levels of AMM and compare them with the composition of gut microbiota in critically ill patients in the acute and chronic stages. Methods: In this prospective observational pilot study, we analyzed the temporal dynamics of the gut microbiome and the AMM spectrum across two distinct subgroups-acute critical ill (ACI) patients with nosocomial pneumonia and chronically critically ill (CCI) patients (9 subjects each group)-as well as performed comparison with 23 healthy volunteers. The AMM levels for each patient were measured using GC-MS in simultaneously taken serum and fecal samples (SFS). These parameters were compared with 16S rRNA fecal microbiome profiles. Results: The observed proportions of bacterial taxa suggest a significant gut dysbiosis in the ACI and the CCI patients. Stronger imbalance in microbiome composition and dynamics observed in the ACI patients compared to the CCI ones resonates with a higher severity in the former group. The total levels of AMM in serum samples were higher for the ACI patients than for the CCI patients (3.7 (1.4-6.3) and 1.1 (1.0-1.6) μM, respectively; p = 0.0003). The qualitative composition of the SFS was also altered. We discovered significant associations between gut microbial taxa levels and metabolite concentrations in blood serum as well as in feces in each of the ACI and the CCI patients. Conclusions: Aromatic microbial metabolite profiles in the gut and the serum are interlinked and reflect a disruption of the gut microbial community in critically ill patients.

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Section: Introductionmentioning

confidence: 99%

Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study

et al. 2020

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“…These data strongly suggest it could be beneficial to monitor and modulate coagulation in IE. Among coagulation parameters, D-dimers have been previously identified as a marker able to provide important insights into the infection-related coagulation abnormalities [13][14][15]. Three studies have evaluated the prognostic role of D-dimers in IE.…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis

Zampino

Iossa

Ursi

et al. 2021

JCM

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(1) Background: The aim of this study was to assess the clinical significance and prognostic role of the main hemostasis parameters in infective endocarditis (IE): prothrombin time as international normalized ratio (PT-INR), activated partial thromboplastin time (aPTT), fibrinogen, D-dimers, platelet count, homocysteine. (2) Methods: We studied 337 patients with IE. Clinical, hemato-chemical and echocardiography parameters were analyzed. Coagulation parameters were measured on admission. (3) Results: D-dimers levels (p = 0.012) and a prolonged PT-INR (p = 0.013) were associated with higher in-hospital mortality, while prolonged aPTT (p = 0.021) was associated with increased 1-year mortality. Staphylococcus aureus (S. aureus) infection (p = 0.003), prosthetic valve endocarditis (PVE) (p = 0.001), surgical indication (p = 0.002) and higher D-dimer levels (p = 0.005) were independent predictors of in-hospital mortality. PVE (p = 0.001), a higher Charlson Comorbidity Index (p = 0.049), surgical indication (p = 0.001) and prolonged aPTT (p = 0.012) were independent predictors of 1-year mortality. Higher levels of D-dimers (p < 0.001) and a shorter aPTT (p < 0.001) were associated with embolic complications of IE. S. aureus etiology was bound to higher D-dimers levels (p < 0.001) and a shorter aPTT (p = 0.006). (4) Conclusions: Elevated D-dimers are associated with a higher risk for in-hospital mortality in IE patients. High D-dimers and a short aPTT are associated with a higher risk for embolic events in IE. A longer aPTT is associated with 1-year mortality.

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Gut Microbiome in Critical Illness (Review)

Черневская

Белобородова

2018

Obŝaâ reanimatologiâ

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Radical changes in the composition, diversity and metabolic activity of gut microbiome in critically ill patients most probably affect adversely the outcome of treatment. Microbiota dysfunction may be a predictor and presumably the main cause of infectious complications and sepsis. Clinicists use objective scales for evaluation of patient condition severity including specific parameters of disorders of organs and systems; however, microbiota function is not considered specific and, hence, not evaluated. Technical capabilities of the recent decade have allowed characterizing the intestinal microbiota and that helped understanding the ongoing processes. The authors have analyzed data about the role of intestinal microbiota as a metabolic 'reactor' during critical states, possible complications related to misbalance of 'harmful' and 'beneficial' bacteria, and examined potential of a targeted therapy aimed directly at correction of intestinal microbiota. Search for papers was carried out using Scopus and Web of Science databases 2001 to 2018 years: (Gut Microbiota) AND (Critically ill OR Intensive care unit), key words taken for the search were: intestinal microbiota, metabolism, sepsis, antibiotics, critically ill patients, multiple organ failure. A number of questions in understanding of the interaction between gut microbiome and host remain open. It is necessary to take into account interference of microbial metabolism while assessing metabolome of patients with sepsis. Among low-molecular compounds found in blood of sepsis patients, special attention should be paid to molecules that can be classified as ‘common metabolites’ of humans and bacteria, for example, degradation products of aromatic compounds, which many-fold rise in blood of septic patients. It is necessary to take into consideration and experimentally model changes in the human internal environment, which occur during radical transformation of microbiome in critically ill patients. Such approach brings in new prospects for objective monitoring of diseases by evaluating metabolic profile at a particular moment of time based on integral indices reflecting the status of microbiome/metabolome system, which will supply new targets for therapeutic intervention in future.

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Sepsis 2016 Agra, India

Cited by 3 publications

References 1 publication

Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study

Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study

Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis

Gut Microbiome in Critical Illness (Review)

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