SepsEast and COVID-19: Time to Make a Difference

Lainščak, Mitja; Šustić, Alan; Beneš, Jan; Czuczwar, Mirosław; Janković, Radmilo; Kirov, Mikhail Y.; Kula, Roman; Kusza, Krzysztof; Podbregar, Matej; Săndesc, Dorel; Bedreag, Ovidiu Horea; Szułdrzyński, Konstanty; Záhorec, R; Hegyi, Péter; Molnár, Zsolt

doi:10.22514/sv.2020.16.0001

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…However, it has long been reported by key opinion leaders of intensive care medicine in the region, that although we are more than 3 decades after the changing of the socialist system, several fundamental issues are still to be solved (31,32). The most burning is the lack of human resources, including ICU nurses and doctors alike.…”

Section: Discussionmentioning

confidence: 99%

Extracorporeal Cytokine Removal in Critically Ill COVID-19 Patients: A Case Series

et al. 2021

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Introduction: Extracorporeal hemoadsorption (HA) is a potential adjunctive therapy in severe cases of COVID-19 associated pneumonia. In this retrospective study we report data from critically ill patients treated with HA during the first and second wave of the pandemic.Patients and Methods: All patients, who received HA therapy with CytoSorb within the first 96 h of intensive care unit (ICU) admission without hospital-acquired bacterial superinfection, were included. Clinical and laboratory data were collected: on admission, before (TB) and after (TA) HA therapy.Results: Out of the 367 COVID-19 cases, 13 patients were treated with CytoSorb, also requiring mechanical ventilation and renal replacement therapy. All patients were alive at the end of HA, but only 3 survived hospital stay. From TB-TA there was a tendency of decreasing norepinephrine requirement: 193.7 [IQR: 34.8–270.4] to 50.2 [6.5–243.5] ug/kg/day and increasing PaO2/FiO2 ratio 127.8 (95% CI: 96.0–159.6) to 155.0 (115.3–194.6) mmHg but they did not reach statistical significance (p = 0.14 and 0.58, respectively). Treatment related adverse events were not reported.Conclusion: The treatment was well-tolerated, and there was a tendency toward an improvement in vasopressor need and oxygenation during the course of HA. These observations render the need for prospective randomized trials.

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Section: Discussionmentioning

confidence: 99%

Extracorporeal Cytokine Removal in Critically Ill COVID-19 Patients: A Case Series

et al. 2021

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SepsEast Registry indicates high mortality associated with COVID-19 caused acute respiratory failure in Central-Eastern European intensive care units

Beneš

Jankowski

Szułdrzyński

et al. 2022

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The coronavirus disease (COVID-19) pandemic caused unprecedented research activity all around the world but publications from Central-Eastern European countries remain scarce. Therefore, our aim was to characterise the features of the pandemic in the intensive care units (ICUs) among members of the SepsEast (Central-Eastern European Sepsis Forum) initiative. We conducted a retrospective, international, multicentre study between March 2020 and February 2021. All adult patients admitted to the ICU with pneumonia caused by COVID-19 were enrolled. Data on baseline and treatment characteristics, organ support and mortality were collected. Eleven centres from six countries provided data from 2139 patients. Patient characteristics were: median 68, [IQR 60–75] years of age; males: 67%; body mass index: 30.1 [27.0–34.7]; and 88% comorbidities. Overall mortality was 55%, which increased from 2020 to 2021 (p = 0.004). The major causes of death were respiratory (37%), cardiovascular (26%) and sepsis with multiorgan failure (21%). 1061 patients received invasive mechanical ventilation (mortality: 66%) without extracorporeal membrane oxygenation (n = 54). The rest of the patients received non-invasive ventilation (n = 129), high flow nasal oxygen (n = 317), conventional oxygen therapy (n = 122), as the highest level of ventilatory support, with mortality of 50%, 39% and 22%, respectively. This is the largest COVID-19 dataset from Central-Eastern European ICUs to date. The high mortality observed especially in those receiving invasive mechanical ventilation renders the need of establishing national–international ICU registries and audits in the region that could provide high quality, transparent data, not only during the pandemic, but also on a regular basis.

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SepsEast and COVID-19: Time to Make a Difference

Cited by 2 publications

References 24 publications

Extracorporeal Cytokine Removal in Critically Ill COVID-19 Patients: A Case Series

Extracorporeal Cytokine Removal in Critically Ill COVID-19 Patients: A Case Series

SepsEast Registry indicates high mortality associated with COVID-19 caused acute respiratory failure in Central-Eastern European intensive care units

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