Sepiolite based materials for storage and slow release of nitric oxide

Fernandes, Ana C.; Antunes, Fernando; Pires, João

doi:10.1039/c3nj00452j

Cited by 24 publications

(29 citation statements)

References 44 publications

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“…However, as shown below, NO loaded MIP‐177 will produce a positive effect on cell migration at concentrations of 90 μg mL −1 , for which no toxicity was found. Compared with previous work, where all porous materials studied for the same purpose presented at least 20 % toxicity with HeLa cells after 72 hours, no toxicity was observed in the present case with HeLa cells (a comparison with other MOFs is presented in the Supporting Information).…”

Section: Resultscontrasting

confidence: 70%

“…[12,13,31,32] Thek inetic desorption curve in Figure 3b)s hows quick NO release in the first 2hours,reaching an equilibrium after 20 hours.N Oa mounts released from MIP-177 (1.7 mmol mg À1 ;a bout 55 %o ft he loaded amount) exceed those of previously reported porous materials.F or example, zeolites,clay-based materials and titanosilicates such as ETS-10, ETS-4 and some modified formulae all present values 1.7 mmol mg À1 . [9,10,[33][34][35][36] Furthermore,t he release performance of MIP-177 is higher than reported for most MOFs, only CPO-27 exceeds the value of MIP-177. [12,13,19] Remarkably,4 5% of the loaded NO is retained in the material even under high vacuum, which is in agreement with the formation of strongly-bound nitrite species (Figure 1a nd 2).…”

Section: Therapeutic No Releasementioning

confidence: 74%

“…NO amounts released from MIP‐177 (1.7 μmol mg −1 ; about 55 % of the loaded amount) exceed those of previously reported porous materials. For example, zeolites, clay‐based materials and titanosilicates such as ETS‐10, ETS‐4 and some modified formulae all present values ≤1.7 μmol mg −1 . Furthermore, the release performance of MIP‐177 is higher than reported for most MOFs, only CPO‐27 exceeds the value of MIP‐177 .…”

Section: Resultsmentioning

confidence: 89%

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Tuning Cellular Biological Functions Through the Controlled Release of NO from a Porous Ti‐MOF

et al. 2020

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Materials for the controlled release of nitric oxide (NO) are of interest for therapeutic applications. However, to date, many suffer from toxicity and stability issues, as well as poor performance. Herein, we propose a new NO adsorption/release mechanism through the formation of nitrites on the skeleton of a titanium‐based metal–organic framework (MOF) that we named MIP‐177, featuring a suitable set of properties for such an application: (i) high NO storage capacity (3 μmol mg−1solid), (ii) excellent biocompatibility at therapeutic relevant concentrations (no cytotoxicity at 90 μg mL−1 for wound healing) due to its high stability in biological media (<9 % degradation in 72 hours) and (iii) slow NO release in biological media (≈2 hours for 90 % release). The prospective application of MIP‐177 is demonstrated through NO‐driven control of mitochondrial respiration in cells and stimulation of cell migration, paving the way for the design of new NO delivery systems for wound healing therapy.

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Section: Resultscontrasting

confidence: 70%

Section: Therapeutic No Releasementioning

confidence: 74%

Section: Resultsmentioning

confidence: 89%

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Tuning Cellular Biological Functions Through the Controlled Release of NO from a Porous Ti‐MOF

et al. 2020

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“…Nanocompósitos com polietilenoamina Ácido fólico [11] Nanocompósito com polypyrrole Aspirina [12] Microesferas de quitosana utilizando PLG organofilizada Diclofenaco sódico [13] PLG sozinha Lapachol [14] PLG liofilizada Ofloxacina [15] Compósito para a formação de hidrogel com carboximetilcelulose-g-poli(ácido acrílico) e alginato de sódio Diclofenaco [16] Compósito para a formação de hidrogel goma guar-gpoli(ácido acrílico) e alginato de sódio Diclofenaco [17] Sepiolita Pilarização Óxido nítrico [18] Fonte: Arquivo do autor, 2015.…”

Section: Forma Utilizada Fármaco Referênciaunclassified

“…Um exemplo disso foi a utilização da argila sepiolita para o carreamento de óxido nítrico (NO) com finalidade terapêutica. Esta argila foi importante na redução da cinética de liberação de NO por via endógena, controlando, de forma crucial e evitando efeitos adversos [18].…”

Section: Forma Utilizada Fármaco Referênciaunclassified

Utilização de argilas fibrosas e tubulares para a liberação modificadas de fármacos: uma revisão

Silva¹,

Vilarinho²,

Barud

et al. 2016

Matéria (Rio J.)

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RESUMONas últimas décadas o uso de argilominerais nas áreas de Ciência e Engenharia de Materiais tem recebido notória atenção para a sua utilização no carreamento de fármacos. Dentre os diversos tipos de argilas, as fibrosas e as tubulares tem sido utilizadas na preparação de bionanocompósitos, devido as suas propriedades inerentes, como exemplo a elevada área superficial. Esta pesquisa visou o levantamento bibliográfico da utilização das argilas tubulares e fibrosas para o carreamento de fármacos. A busca por artigos foi realizado no banco de dados Web of Science, utilizando combinação dos termos: Fibrous Clay and drug delivery, Tubular Clay and drug delivery, Halloysite and drug delivery, Imogolite and drug delivery, Palygoskite and drug delivery e Sepiolite and drug delivery. Foram encontrados o total de 36 artigos durante a pesquisa. Observouse que a maioria dos artigos utilizam as argilas em combinação com outros materiais (com formação de compósitos e blendas), principalmente polímeros, a fim de expandir as propriedades que melhoram a vetorização de insumos farmacêuticos ativos (IFAs), tais como a modificação do tamanho dos poros, do pH, da energia de ligação entre as moléculas, entre outros. Assim, evidencia-se que o interesse pela utilização das argilas no campo terapêutico tem aumentado, mostrando a relevância de pesquisas na área de medicamentos e materiais.Palavras-chave: argila fibrosa, argila tubular, argilominerais, carreamento de fármacos. ABSTRACTIn recent decades the use of clay minerals in the areas of Materials Science and Engineering has received notable attention for its use in carrying of drugs. Among the various types of clay, and fibrous tubes have been used in the preparation of bionanocompósitos due to their inherent properties, for example high surface area. This research aimed a review at the literature of the use of tubular and fibrous clays for the carrying of drugs. The search for articles was conducted in the Web of Science database, using combination of terms: Fibrous Clay and drug delivery, Tubular Clay and drug delivery, Halloysite and drug delivery, imogolite and drug delivery, drug delivery and Palygoskite and Sepiolite and drug delivery. Found total of 36 articles during the search. It was observed that most of the clay articles used in combination with other materials (with formation of composites and blends), in particular polymers in order to extend the properties that improve the vectoring of active pharmaceutical ingredients (APIs), such as modification pore size, the pH, the binding energy between molecules, among others. Thus, it is clear that the interest in the use of clays in the therapeutic field has increased, showing the relevance of research in the area of drugs and materials.

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Tuning Cellular Biological Functions Through the Controlled Release of NO from a Porous Ti‐MOF

et al. 2020

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Sepiolite based materials for storage and slow release of nitric oxide

Cited by 24 publications

References 44 publications

Tuning Cellular Biological Functions Through the Controlled Release of NO from a Porous Ti‐MOF

Tuning Cellular Biological Functions Through the Controlled Release of NO from a Porous Ti‐MOF

Utilização de argilas fibrosas e tubulares para a liberação modificadas de fármacos: uma revisão

Tuning Cellular Biological Functions Through the Controlled Release of NO from a Porous Ti‐MOF

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