Sepiolite, a Potential Excipient for Drugs Subject to Oxidative Degradation

Hermosı́n, M.C.; Cornejo, J.; White, Joe L.; Hemx, Stanley L.

doi:10.1002/jps.2600700219

Cited by 28 publications

(12 citation statements)

References 9 publications

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“…The lesser oxidizing power of sepiolite than that of palygorskite in the presence of an aqueous solution of hydrocortisone has been attributed to the very low iron content of sepiolite (Hermosin et al, 1981). The ESR spectra of sepiolite (Figure 2) also show the same two features observed for palygorskite: a structural Fe 3+ signal at g = 4.2 and a surface-adsorbed iron oxide or hydroxide at g --2.…”

Section: Forms Of Fe Z+ In Palygorskite and Sepiolitementioning

confidence: 70%

“…The hydrocortisone-clay interactions were carried out in an aqueous medium as described earlier (Cornejo et al, 1980;Hermosin et al, 1981). The quantity of hydrocortisone adsorbed by the clays was measured by the decrease in the intensity of the UV absorbance of the supernatant liquid at 254 nm after centrifuging to separate the clay.…”

Section: Methodsmentioning

confidence: 99%

“…The quantity of hydrocortisone adsorbed by the clays was measured by the decrease in the intensity of the UV absorbance of the supernatant liquid at 254 nm after centrifuging to separate the clay. High-pressure liquid chromatography (HPLC) was also used to measure the amount of hydrocortisone degraded by the clays (Cornejo et al, 1980;Hermosin et al, 1981).…”

Section: Methodsmentioning

confidence: 99%

“…Both signals are weaker in sepiolite than in palygorskite and depend on the amount of total iron in the clays. These values for sepiolite and palygorskite are 3.2 mg/g and 26.6 rag/g, respectively (Cornejo et al, 1980;Hermosin et al, 1981). The low iron content of sepiolite minimizes the possiblity of electron-electron interactions arising from neighboring paramagnetic ions in the structure.…”

Section: Forms Of Fe Z+ In Palygorskite and Sepiolitementioning

confidence: 99%

“…Copyright O 1983, The Clay Minerals Society skite (Hermosin et al,, 1981). The present investigation examines the role of Fe a+ in the catalytic oxidation of hydrocortisone by palygorskite and sepiolite.…”

Section: Introductionmentioning

confidence: 98%

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Role of Ferric Iron in the Oxidation of Hydrocortisone by Sepiolite and Palygorskite

Cornejo

Hermosı́n

White

et al. 1983

Clays and clay miner.

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Abstract--The role of adsorbed and structural Fe n+ in palygorskite and sepiolite with respect to the oxidation of hydrocortisone in aqueous suspension has been evaluated using electron spin resonance and UVvisible spectroscopy. Natural surface-adsorbed Fe 3+ showed an important activity in the oxidation process, although smaller than octahedral Fe 3+. The kinetics of oxidative degradation of hydrocortisone by palygorskite appear to be composed of two apparent first order reactions which may be associated with two kinds of sites for Fe in palygorskite. The lower oxidizing power of sepiolite for hydrocortisone degradation is due to its very low Fe z+ content.

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Section: Forms Of Fe Z+ In Palygorskite and Sepiolitementioning

confidence: 70%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Forms Of Fe Z+ In Palygorskite and Sepiolitementioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 3 more Smart Citations

Role of Ferric Iron in the Oxidation of Hydrocortisone by Sepiolite and Palygorskite

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Clays and clay miner.

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Study of Attapulgite for Human Health

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The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021 This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Sepiolite, a Potential Excipient for Drugs Subject to Oxidative Degradation

Cited by 28 publications

References 9 publications

Role of Ferric Iron in the Oxidation of Hydrocortisone by Sepiolite and Palygorskite

Role of Ferric Iron in the Oxidation of Hydrocortisone by Sepiolite and Palygorskite

Study of Attapulgite for Human Health

Nanominerals and Nanomaterials Utilized in Pharmacy and Therapeutics

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