Separation selectivity in chiral capillary electrophoresis with charged selectors

Sensitive chiral analysis by capillary electrophoresis

“…Chiral separations performed by CE in aqueous media may be included in the EKC mode because the discrimination of the enantiomers of a chiral compound is due to their different interaction with a chiral selector, that is, enantiomers are distributed in a different way between the bulk solution and the chiral selector according to a chromatographic mechanism [6][7][8]. It is important to note that the chiral separation principle is absolutely the same in the enantiomeric separation of a charged chiral analyte with a neutral chiral selector and in that of an uncharged chiral analyte with a charged chiral selector.…”

Chiral separation by chromatographic and electromigration techniques. A Review

“…In capillary electrochromatography (CEC), which represents a recent technique, similarly to HPLC chiral stationary phases or chiral mobile phase additives can be applied. Several comprehensive reviews give a survey of chiral separation principles used in CE and applications to various compound classes [10][11][12][13][14][15][16][17].…”

“…The reader will be referred to specialized review articles for details. Several recent comprehensive reviews and book articles summarize chromatographic [3][4][5][6][7][8][9] and electrophoretic methods [10][11][12][13][14][15][16][17] for chiral separation in general.…”

Chiral and Chirality Discrimination on Helical Polyacetylenes

“…[26][27][28][29][30] We have recently found that a novel optically active, stereoregular poly(phenylacetylene) derivative bearing a β-cyclodextrin residue as the side group (poly-25) exhibits a macromolecular helicity inversion accompanied by a color change responding to molecular and chiral recognition events that occurred at the remote side chain (Fig. 6).…”