Separation of quaternary conjugate salt systems by fractional crystallization

Synthesis of chiral crystallization processes

“…This process combines the two racemates in equal amounts to form the conjugate salt system. The compatible salts are separated by a fractional crystallization scheme described in Berry and Ng (1996). The process paths are also shown on the phase diagram in Figure 15.…”

“…Fractional crystallization was studied by Cisternas and Rudd (19931, Dye and Ng (1995b), Cisternas and Swaney (19981, Cisternas (1999), and Thomsen et al (19981, among others. Design of crystallization processes for recovering pure solids from conjugate salt pairs was considered by Berry and Ng (1996); they showed that the same method could be used to resolve racemic mktures.…”

“…These techniques have been discussed extensively in the literature (Berry and Ng, 1996;Wibowo and Ng, 2000). For example, an isothermal ternary phase diagram with a solvent indicates whether separation by fractional crystallization is possible.…”

Representation of material balance for fractional crystallization of reciprocal salt pair Systems: KNO₃ production case study

“…These studies can be classified into two categories: those that use a phase diagram to identify the types of processes that may be applied to specific types of solid-liquid equilibrium behavior [1][2][3][4], and those that use a network flow model between a priori determined thermodynamic states that allow selection of an optimal structure [5][6][7].…”

“…Berry and Ng [4] gave a method for the separation of salts in the pure, solid state for reciprocal salt pair systems. They identified three classes of separations that could be used to separate simple salts from a solution.…”