Separation of physiological factors influencing glucose insulin kinetics in diabetic patients

Abstract

A new quantitative method was developed for separation of physiological factors influencing glucose intolerance in diabetes mellitus using a three-compartmental model and the intravenous glucose tolerance test (IVGTT) in humans. The present model includes the physiologic factors of the hepatic glucose balance function, the peripheral tissue's glucose utilization rate, and the insulin secretion rate. The insulin sensitivity parameter and hepatic glucose sensitivity parameter were estimated in optimal fitting of the model-based data of glucose and insulin concentrations to the measured IVGTT data in 9 normal and 11 diabetic subjects. The results show that these sensitivity parameters are important for separation of the effects of the interactive physiologic factors, and, also useful in evaluating different glucose-insulin kinetics in 3 clinical groups of normal and diabetic subjects.

Personalized glucose-insulin model based on signal analysis

“…These prominent glucose appearance time lag effects are observed in mixed meal tolerance tests. The model presentation of Min et al (1984) and Min, G.B, Woo E.J, ( 1986) is evaluated for IVGTT glucose responses to establish the values of insulin resistance in four different test groups. They described the glucose currents with current sources where voltages across the resistances are the results of the product of current value and resistor value.…”

“…We will relate the capacitor value proportionally to the individual body weight according C = 80mL/kg (Min, B.G et al 1984) representing the volume of the blood compartment. Based on the capacitor value we can derive the values for the belonging resistors R 1 and R 2 and the current sources I B and I H .…”

“…One of the first modeling descriptions applied in glucose-insulin analysis, based on an electrical network, was investigated and published byMin et al in 1984 andMin, G.B, Woo E.J, (1986). They proposed the model depicted in Fig.4…”

High Resolution Free Triiodothyronine-Thyrotropin (Ft3-Tsh) Responses to a Single Oral Dose of Liothyronine in Humans: Evidence of Distinct Inter-Individual Differences Unraveled Using an Electrical Network Model

“…The success of such an approach was demonstrated earlier in nerve impulse conduction 9,10 and in glucose control modeling. 11,12 The influence of the gastrointestinal tract (GIT) is thought to have a prominent effect on the dissolution behavior and release to the blood compartment of an ingested drug. This effect is demonstrated in the modeling results of our present treatise.…”