Separation of norepinephrine enantiomers, DOPA enantiomers and dopamine derivatized with o-phthalaldehyde-N-acetyl-l-cysteine by high-performance liquid chromatography

Nimura, Noriyuki; Iwaki, Kazuo; Kinoshita, Toshio

doi:10.1016/0021-9673(87)80044-4

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1993

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Mirror Images: The Analysis of Pharmaceutical Enantiomers

Pasutto

1992

The Journal of Clinical Pharma

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Pharmaceutical enantiomers often exhibit different pharmacodynamic and pharmacokinetic properties. Stereospecific chromatographic assays are available to separate these stereoisomers. Therapeutic agents often contain chemical functional groups (e.g. amino, hydroxyl, carbonyl, and carboxylic acid). These can be reacted with enantiomerically pure reagents to give diastereoisomers suitable for analysis on achiral gas chromatographic (GC) and high performance liquid chromatographic (HPLC) columns. Alternatively, derivatized or underivatized drugs may be resolved on chiral chromatographic phases. A wide variety of GC (e.g. amino acid, cyclodextrin, and metal-complex) and HPLC (mobile phase additive, crown ether, pi-pi interaction and related phases, protein, cyclodextrin, polysaccharide, methacrylate and amide polymer, and ligand exchange) columns are commercially available. This article reviews the chromatographic separation of enantiomers.

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