Separation of no-carrier-added 113,117mSn and 113m,114mIn from alpha particle irradiated natural cadmium target

Ghosh, Kaustab; Maiti, Moumita; Lahiri, Susanta

doi:10.1007/s10967-012-2115-1

Cited by 7 publications

(3 citation statements)

References 29 publications

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“…In vivo behavior was analogous to that of 111 In-DTPA- d -Phe 1 -octreotide . The use of nat Cd targets has been investigated, but coproduction of 111,113m In is unavoidable and yields are drastically decreased. , Neutron irradiation of enriched 113 In has also been reported . In lieu of a detailed summary below, here we simply report that 114m In is capable of damaging cell DNA and the β – particle decay appears suitable for treatment of large tumors (>1 cm 3 ). , Indium-114m has undergone preclinical studies for palliative treatment of advanced lymphoid malignancy and for targeting of HER2-expressing malignant tumors, as well as clinical studies to treat lymphoid cell malignancy. ,− …”

Section: Indiummentioning

confidence: 89%

“…408 The use of nat Cd targets has been investigated, but coproduction of 111,113m In is unavoidable and yields are drastically decreased. 408,409 Neutron irradiation of enriched 113 In has also been reported. 410 In lieu of a detailed summary below, here we simply report that 114m In is capable of damaging cell DNA and the β − particle decay appears suitable for treatment of large tumors (>1 cm 3 ).…”

Section: Indium-114m Productionmentioning

confidence: 96%

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Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

2018

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Radiometals possess an exceptional breadth of decay properties and have been applied to medicine with great success for several decades. The majority of current clinical use involves diagnostic procedures, which use either positron-emission tomography (PET) or single-photon imaging to detect anatomic abnormalities that are difficult to visualize using conventional imaging techniques (e.g., MRI and X-ray). The potential of therapeutic radiometals has more recently been realized and relies on ionizing radiation to induce irreversible DNA damage, resulting in cell death. In both cases, radiopharmaceutical development has been largely geared toward the field of oncology; thus, selective tumor targeting is often essential for efficacious drug use. To this end, the rational design of fourcomponent radiopharmaceuticals has become popularized. This Review introduces fundamental concepts of drug design and applications, with particular emphasis on bifunctional chelators (BFCs), which ensure secure consolidation of the radiometal and targeting vector and are integral for optimal drug performance. Also presented are detailed accounts of production, chelation chemistry, and biological use of selected main group and rare earth radiometals.

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Section: Indiummentioning

confidence: 89%

Section: Indium-114m Productionmentioning

confidence: 96%

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

2018

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“…[8]. In a recent experiment, we produced 111,113m,114m In along with 113,117m Sn by aparticle activation on natural cadmium target [16]. 111 In was also produced by heavy ion activations ( 7 Li, 11 B) on nat Ag target [17][18][19] and 12 C activation on rhodium target [20].…”

Section: Introductionmentioning

confidence: 99%

Separation of no-carrier-added 111In and 109Cd from α-particle induced Ag target using glass wool surface

Lahiri

Maiti

Ghosh

2015

J Radioanal Nucl Chem

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Alpha particle bombardment on thick silver target produced no-carrier-added (NCA) 111 In and 109 Cd radioisotopes in the matrix. NCA 111 In and 109 Cd were separated from the target matrix by solid-liquid extraction using glass wool surface. At 10 -2 M HNO 3 concentration, *100 % 111 In and 93 % 109 Cd were adsorbed on the glass wool surface along with 16 % contamination of bulk Ag. After quantitative removal of bulk Ag from glass wool surface by de-ionized water, 111 In and 109 Cd were desorbed by 0.1 M HNO 3 . The mutual separation between 111 In and 109 Cd was achieved by column chromatography using Dowex 50WX-50 resin.

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