Separation of fumaric acid by amine extraction without and with 1-octanol as phase modifier

Kloetzer, Lenuţa; Ilica, Roxana-Andreea; Caşcaval, Dan; Galaction, Anca‐Irina

doi:10.1016/j.seppur.2019.115724

Cited by 11 publications

(35 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pH value of the aqueous phase was maintained at 2, this being the pH value corresponding to the maximum extraction yield [ 8 ]. The pH’s adjustment to the prescribed value was made with a solution of 3% sulfuric acid (Sigma-Aldrich Chemie GmbH, Steinheim, Germany, p.a.…”

Section: Methodsmentioning

confidence: 99%

“…The efficiency of physical extraction can be significantly improved by using extractants that are able to transform the fumaric acid by a chemical reaction into a compound soluble in organic phase. This method is called reactive extraction and it has previously been studied for the purpose of efficiently separating fumaric acid using Amberlite LA-2 dissolved in various solvents with different dielectric constants [ 8 ]. The reactive extraction of fumaric acid occurs by an interfacial reaction with salt or the formation of an aminic adduct, depending on the organic phase’s polarity.…”

Section: Introductionmentioning

confidence: 99%

“…The reactive extraction of fumaric acid occurs by an interfacial reaction with salt or the formation of an aminic adduct, depending on the organic phase’s polarity. The reactive extraction yield reached over 95% for solvents with a higher polarity when ammonium fumarate was produced, the process’s efficiency being improved by adding a phase modifier [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…On the basis of the information resulting from studies on the reactive extraction of fumaric acid from pure aqueous solutions and simulated broths without biomass [ 8 ], an investigation of this acid’s separation by the same technique from Rhizopus oryzae suspensions was performed. Therefore, the influence of the solvent dielectric constant and 1-octanol addition on the interfacial mass transfer rate of fumaric acid was analyzed in direct relation to the fungal biomass’s concentration.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Direct Extraction of Fumaric Acid from Rhizopus oryzae Suspensions—Interfacial Mass Transfer

et al. 2021

Self Cite

View full text Add to dashboard Cite

Experimental studies on the reactive extraction of fumaric acid with Amberlite LA-2 from Rhizopus oryzae suspensions using three solvents with different dielectric constants varying from 9.08 to 1.90 (dichloromethane, n-butyl acetate, and n-heptane, respectively) underlined the particular behavior of the extraction system in the presence of fungal biomass. The interfacial mass flow of the reaction product was found to be significantly affected by the biomass, due mainly to its adsorption onto the phase separation interface, this leading to the appearance of a physical barrier against the solute’s transfer. However, the magnitude of the adsorption phenomenon was found to depend on Rhizopus oryzae’s affinity for the solvent phase, which increased significantly from dichloromethane to n-heptane. The negative influence of the biomass on the interfacial mass transfer can be partially counteracted by adding 1-octanol into the organic phase, improving the solvent’s ability to solve the fumaric acid–Amberlite LA-2 complex and simplifying the reactive extraction mechanism, effects that were found to be more important for low-polar solvents. Consequently, for the same mixing intensity, the maximum amplification factor was reached for n-heptane, its value being almost 5–6 times higher than that obtained for dichloromethane and over 2 times higher than that obtained with n-butyl acetate.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Direct Extraction of Fumaric Acid from Rhizopus oryzae Suspensions—Interfacial Mass Transfer

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, many works have demonstrated that lignin models could also be oxidized into fumaric acid under hydrothermal conditions [26][27][28][29][30]. As a building block, fumaric acid has been widely studied [31]. It was reported that maleic and fumaric acid can degrade to acrylic [32,33].…”

Section: Introductionmentioning

confidence: 99%

Production of Acrylic Acid from Biomass-Derived Fumaric Acid under Hydrothermal Conditions

et al. 2021

View full text Add to dashboard Cite

Production of energy and chemicals from biomass resources has been regarded as one promising method to address the challenge of global warming. In this research, production of acrylic acid from fumaric acid, one of the biomass-derived building blocks, is proposed. CuO was employed as a solid oxidant, which showed excellent activity and selectivity for the production of acrylic acid, and water played an essential role in acting as not only a solvent but also a catalyst in this process. An optimum acrylic acid yield of 76.4% was successfully obtained after the reaction of fumaric acid with CuO at 300 °C for only 60 s.This research provides a green and highly efficient way to produce value-added chemicals from biomass-derived building blocks, and thus is promising for practical application.

show abstract

Application of reactive extraction for the separation of pseudomonic acids: Influencing factors, interfacial mechanism, and process modelling

et al. 2021

Self Cite

View full text Add to dashboard Cite

Mupirocin (a mixture of A, B, C, and D pseudomonic acids-four complex, similar structures) is an antibiotic belonging to the monocarboxylic acid class, used to cure infections caused by bacteria (Gram-positive), especially methicillin-resistant Staphylococcus aureus (MRSA). Its biotechnological production and separation need constant attention, as improving antibiotics is important in the pharmaceutical industry. This is the first study regarding pseudomonic acids separation through reactive extraction; the experiments were focused on finding a proper combination of extractant and diluent for optimization of the separation yield. The pH influence (4-9) and extractant (TOA and Amberlite LA-2, 5-20 g/L) concentration dissolved in n-heptane (green solvent) have been analyzed, obtaining the maximum extraction yield (88.78%) at pH 4, 20 g/L extractant, and 10% octanol added to the organic solvent. The addition of the phase modifier, 1-octanol, improved the extraction yield by 2.6 times for Pseudomonic acid A due to interactions of formed complexes with the phase modifier that improves its solubility. The experimental results for determining the mechanism of the interfacial reaction showed that, regardless of the pH value and solvent polarity (modified by the addition of 1-octanol), only one molecule of Pseudomonic acid A and extractant react at the aqueous-organic interface. In addition, the system was modelled and optimized with a methodology combining artificial neural networks (ANN) and differential evolution.

show abstract

Separation of fumaric acid by amine extraction without and with 1-octanol as phase modifier

Cited by 11 publications

References 15 publications

Direct Extraction of Fumaric Acid from Rhizopus oryzae Suspensions—Interfacial Mass Transfer

Direct Extraction of Fumaric Acid from Rhizopus oryzae Suspensions—Interfacial Mass Transfer

Production of Acrylic Acid from Biomass-Derived Fumaric Acid under Hydrothermal Conditions

Application of reactive extraction for the separation of pseudomonic acids: Influencing factors, interfacial mechanism, and process modelling

Contact Info

Product

Resources

About