Separation of Fiber Tracts within the Human Cingulum Bundle using Single-Shot STEAM DTI

Karaus, Alexander; Hofer, Sabine; Frahm, Jens

doi:10.2174/1874347100903010021

Cited by 9 publications

(15 citation statements)

References 15 publications

(18 reference statements)

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“…Relative to full Fourier acquisitions without parallel imaging, the significantly lower number of Fourier lines shortens the image acquisition time by more than a factor of 2 and simultaneously increases the SNR by almost a factor of 3 due to the possibility of using higher flip angles (for more details see Karaus et al, 2009). …”

Section: Methodsmentioning

confidence: 99%

Reconstruction and dissection of the entire human visual pathway using diffusion tensor MRI

2010

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The human visual system comprises elongated fiber pathways that represent a serious challenge for diffusion tensor imaging (DTI) and fiber tractography: while tracking of frontal fiber bundles may be compromised by the nearby presence of air-filled cavities, nerves, and eye muscles, the anatomic courses of the three main fiber bundles of the optic radiation are subject to pronounced inter-subject variability. Here, tractography of the entire visual pathway was achieved in six healthy subjects at high spatial accuracy, that is, at 1.8 mm isotropic spatial resolution, without susceptibility-induced distortions, and in direct correspondence to anatomic MRI structures. Using a newly developed diffusion-weighted single-shot STEAM MRI sequence, we were able to track the thin optic nerve including the nasal optic nerve fibers, which cross the optic chiasm, and to dissect the optic radiation into the anterior ventral bundle (Meyer's loop), the central bundle, and the dorsal bundle. Apart from scientific applications these results in single subjects promise advances in the planning of neurosurgical procedures to avoid unnecessary damage to the visual fiber system.

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Section: Methodsmentioning

confidence: 99%

Reconstruction and dissection of the entire human visual pathway using diffusion tensor MRI

2010

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“…While this sequence does not provide long diffusion times without T 2 decay, it avoids susceptibility artifacts, allowing anatomically correct fiber tractography independent of magnetic susceptibilities. 226,227,230 Despite its favorable physical properties, Turbo-STEAM DWI is less frequently used because of its low SNR.…”

Section: Stimulated Echo Acquisition Mode (Steam) Dwimentioning

confidence: 99%

The quest for high spatial resolution diffusion‐weighted imaging of the human brain in vivo

Holdsworth

O’Halloran²,

Setsompop

2019

NMR in Biomedicine

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Diffusion‐weighted imaging, a contrast unique to MRI, is used for assessment of tissue microstructure in vivo. However, this exquisite sensitivity to finer scales far above imaging resolution comes at the cost of vulnerability to errors caused by sources of motion other than diffusion motion. Addressing the issue of motion has traditionally limited diffusion‐weighted imaging to a few acquisition techniques and, as a consequence, to poorer spatial resolution than other MRI applications. Advances in MRI imaging methodology have allowed diffusion‐weighted MRI to push to ever higher spatial resolution. In this review we focus on the pulse sequences and associated techniques under development that have pushed the limits of image quality and spatial resolution in diffusion‐weighted MRI.

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“…On the other hand, turbo‐STEAM (stimulated echo acquisition mode) sequences allow for DW MRI without any susceptibility‐induced artifacts. They further avoid the high specific energy absorption rates of fast spin‐echo sequences, which have also been proposed for DW MRI of the prostate .…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the image intensities of an iteratively optimized numerical estimate no longer scale with the square root of the number of k ‐space acquisitions as known for Fourier transform MRI, which turns out to be especially advantageous for highly undersampled acquisitions. The underlying increase in SNR compared with preceding STEAM MRI variants expands the range of possible applications and renders the technique a natural candidate for prostate imaging.…”

Section: Introductionmentioning

confidence: 99%

Diffusion‐weighted MRI of the prostate without susceptibility artifacts: Undersampled multi‐shot turbo‐STEAM with rotated radial trajectories

et al. 2019

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Funding informationDeutsche Krebshilfe e.V.The aim of this study was to develop and evaluate a clinically feasible approach to diffusion-weighted (DW) MRI of the prostate without susceptibility-induced artifacts.The proposed method relies on an undersampled multi-shot DW turbo-STEAM sequence with rotated radial trajectories and a multi-step inverse reconstruction with denoised multi-shot phase maps. The total acquisition time was below 6 min for a resolution of 1.4 × 1.4 × 3.5 mm 3 and six directions at b = 600 s mm −2 . Studies of eight healthy subjects and two patients with prostate cancer were performed at 3 T employing an 18-channel body-array coil and elements of the spine coil. The method was compared with conventional DW echo-planar imaging (EPI) of the prostate. The results confirm that DW STEAM MRI avoids geometric distortions and false image intensities, which were present for both single-shot EPI (ssEPI) and readoutsegmented EPI, particularly near the intestinal wall of the prostate. Quantitative accuracy of the apparent diffusion coefficient (ADC) was validated with use of a numerical phantom providing ground truth. ADC values in the central prostate gland of healthy subjects were consistent with those measured using ssEPI and with literature data.Preliminary results for patients with prostate cancer revealed a correct anatomical localization of lesions with respect to T 2 -weighted MRI in both mean DW STEAM images and ADC maps. In summary, DW STEAM MRI of the prostate offers clinically relevant advantages for the diagnosis of prostate cancer compared with state-of-theart EPI-based approaches. The method warrants extended clinical trials.

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Separation of Fiber Tracts within the Human Cingulum Bundle using Single-Shot STEAM DTI

Cited by 9 publications

References 15 publications

Reconstruction and dissection of the entire human visual pathway using diffusion tensor MRI

Reconstruction and dissection of the entire human visual pathway using diffusion tensor MRI

The quest for high spatial resolution diffusion‐weighted imaging of the human brain in vivo

Diffusion‐weighted MRI of the prostate without susceptibility artifacts: Undersampled multi‐shot turbo‐STEAM with rotated radial trajectories

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