Separation of eicosapentaenoic acid and docosahexaenoic acid by three-zone simulated moving bed chromatography

Wei, Bofeng; Wang, Shaoyan

doi:10.1016/j.chroma.2020.461326

Cited by 12 publications

(8 citation statements)

References 39 publications

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“…In the human body metabolism, LA can be converted into GLA and continue to generate ARA under desaturase catalysis, while LNA generates EPA and DHA after desaturation. 27 ARA, EPA, and DHA have beneficial functions for the brain, 28 eyes, 29 and blood vessels. 30 The high percentage of total functional UFAs in both PC and TAG was observed in panels F and G of Figure 3.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Analysis of Lipid Molecule Profiling and Conversion Pathway in Mandarin Fish (Siniperca chuatsi) during Fermentation via Untargeted Lipidomics

Chen

Zhang

Huang

et al. 2023

J. Agric. Food Chem.

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Lipids are the key aroma contributors and nutrients in fermented fish products. A total of 376 lipid molecules were identified in mandarin fish during fermentation by untargeted lipidomics, including glycerolipids, glycerophospholipids, lysoglycerophospholipid, sphingolipids, fatty acids (FAs), and sterol lipids. Both lipid composition and content changed dynamically during fermentation. Triglyceride (TAG, 30.05%) and phosphatidylcholine (PC, 14.87%) were the two major lipids, with especially 39.36% saturated FAs in PCs and 35.34% polyunsaturated FAs in TAGs. The content of TAGs and PCs reached a peak point at 0 and 6 days, respectively. Fermented mandarin fish expressed a high nutritional value, and the ratio of total linoleic acid/total linolenic acid was about 5:1. Glycerophospholipid metabolism was a potential metabolic pathway, and the oxidation of derived FAs contributed to flavor. These data progress in understanding lipid dynamic variation during fermentation and provide thoughts on controlling the flavor quality and safety of fermented fish products.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Analysis of Lipid Molecule Profiling and Conversion Pathway in Mandarin Fish (Siniperca chuatsi) during Fermentation via Untargeted Lipidomics

Chen

Zhang

Huang

et al. 2023

J. Agric. Food Chem.

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“…The results showed that, in the 2-2-2 mode, the purity of both DHA and EPA reached 99% and the recovery was close to or at 100%. The solvent consumption was 1.11 L/g, which was significantly lower compared with 1.46 L/g in the 1-1-2 mode [42]. In consequence, this kind of variant could improve both the separation performance and the economical efficiency of SMB.…”

Section: Three-zone Smbmentioning

confidence: 90%

Research Progress on the Typical Variants of Simulated Moving Bed: From the Established Processes to the Advanced Technologies

et al. 2023

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Simulated moving bed (SMB) chromatography is a highly efficient adsorption-based separation technology with various industrial applications. At present, its application has been successfully extended to the biochemical and pharmaceutical industrial sectors. SMB possesses the advantages of high product purity and yield, large feed treatment capacity, and simple process control due to the continuous operation mode and the efficient separation mechanism, particularly for difficult separation. Moreover, SMB performs well, particularly for multi-component separation or complicated systems’ purification processes in which each component exhibits similar properties and low resolution. With the development of the economy and technology, SMB technology needs to be improved and optimized to enhance its performance and deal with more complex separation tasks. This paper summarizes the typical variants or modifications of the SMB process through three aspects: zone variant, gradient variant, and feed or operation variant. The corresponding modification principles, operating modes, advantages, limitations, and practical application areas of each variant were comprehensively investigated. Finally, the application prospect and development direction were summarized, which could provide valuable recommendations and guidance for future research in the SMB area.

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“…Algae oil, which is rich in omega-3 PUFAs, can be used as a raw material for these products. However, to meet the desired product characteristics when used in health products, pharmaceuticals, or auxiliary medicines, PUFAs in algae oil must be purified Wei and Wang, 2020). For instance, several omega-3 PUFAs prescription drugs approved by the U.S. Food and Drug Administration for the prevention and treatment of high triglycerides require even higher purity (Hoy and Keating, 2009;Blair and Dhillon, 2014;Kim and McCormack, 2014).…”

Section: Enrichment Of Pufasmentioning

confidence: 99%

Microalgal polyunsaturated fatty acids: Hotspots and production techniques

Chen

et al. 2023

Front. Bioeng. Biotechnol.

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Algae play a crucial role in the earth’s primary productivity by producing not only oxygen but also a variety of high-value nutrients. One such nutrient is polyunsaturated fatty acids (PUFAs), which are accumulated in many algae and can be consumed by animals through the food chain and eventually by humans. Omega-3 and omega-6 PUFAs are essential nutrients for human and animal health. However, compared with plants and aquatic sourced PUFA, the production of PUFA-rich oil from microalgae is still in the early stages of exploration. This study has collected recent reports on algae-based PUFA production and analyzed related research hotspots and directions, including algae cultivation, lipids extraction, lipids purification, and PUFA enrichment processes. The entire technological process for the extraction, purification and enrichment of PUFA oils from algae is systemically summarized in this review, providing important guidance and technical reference for scientific research and industrialization of algae-based PUFA production.

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Separation of eicosapentaenoic acid and docosahexaenoic acid by three-zone simulated moving bed chromatography

Cited by 12 publications

References 39 publications

Analysis of Lipid Molecule Profiling and Conversion Pathway in Mandarin Fish (Siniperca chuatsi) during Fermentation via Untargeted Lipidomics

Analysis of Lipid Molecule Profiling and Conversion Pathway in Mandarin Fish (Siniperca chuatsi) during Fermentation via Untargeted Lipidomics

Research Progress on the Typical Variants of Simulated Moving Bed: From the Established Processes to the Advanced Technologies

Microalgal polyunsaturated fatty acids: Hotspots and production techniques

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