Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism

Skene, Debra J.; Skornyakov, Elena; Chowdhury, Namrata; Gajula, Rajendra P.; Middleton, Benita; Satterfield, Brieann C.; Porter, Kenneth I.; Dongen, Hans P A Van; Gaddameedhi, Shobhan

doi:10.1073/pnas.1801183115

Cited by 144 publications

(206 citation statements)

References 45 publications

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“…Abnormal circadian rhythms have been associated with obesity, T2DM, CVD and hypertension [3,23,30], all components of the Metabolic Syndrome. Shift workers or people who sleep poorly are more likely to develop obesity and T2DM due to circadian clock disruption [31][32][33][34][35][36][37].…”

Section: Metabolic Syndrome Components and Circadian Disruptionmentioning

confidence: 99%

The Circadian Syndrome: is the Metabolic Syndrome and much more!

Zimmet

Alberti

Stern³

et al. 2019

J Intern Med

226

192

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The Metabolic Syndrome is a cluster of cardio‐metabolic risk factors and comorbidities conveying high risk of both cardiovascular disease and type 2 diabetes. It is responsible for huge socio‐economic costs with its resulting morbidity and mortality in most countries. The underlying aetiology of this clustering has been the subject of much debate. More recently, significant interest has focussed on the involvement of the circadian system, a major regulator of almost every aspect of human health and metabolism. The Circadian Syndrome has now been implicated in several chronic diseases including type 2 diabetes and cardiovascular disease. There is now increasing evidence connecting disturbances in circadian rhythm with not only the key components of the Metabolic Syndrome but also its main comorbidities including sleep disturbances, depression, steatohepatitis and cognitive dysfunction. Based on this, we now propose that circadian disruption may be an important underlying aetiological factor for the Metabolic Syndrome and we suggest that it be renamed the ‘Circadian Syndrome’. With the increased recognition of the ‘Circadian Syndrome’, circadian medicine, through the timing of exercise, light exposure, food consumption, dispensing of medications and sleep, is likely to play a much greater role in the maintenance of both individual and population health in the future.

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Section: Metabolic Syndrome Components and Circadian Disruptionmentioning

confidence: 99%

The Circadian Syndrome: is the Metabolic Syndrome and much more!

Zimmet

Alberti

Stern³

et al. 2019

J Intern Med

226

192

View full text Add to dashboard Cite

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“…PER2 directly inhibits the activity of peroxisome proliferator-activated receptor γ (PPARγ), a master regulator of adipogenesis and promotor of lipid storage (Grimaldi et al 2010). Metabolomic studies in humans reveal that many circulating metabolites, with the majority being lipid products, show circadian oscillations, pointing to a specific role of the endogenous circadian clocks in the regulation of the plasma lipid profile (Dallmann et al 2012;Skene et al 2018). In addition to a metabolic role, white adipose tissue contributes to energy homeostasis through the production of adipokines.…”

Section: White and Brown Adipose Tissues Contribute To The Circadian mentioning

confidence: 99%

“…; Skene et al . ). In addition to a metabolic role, white adipose tissue contributes to energy homeostasis through the production of adipokines.…”

Section: Introductionmentioning

confidence: 97%

Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue

Dollet

Zierath

2019

The Journal of Physiology

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Disruption of circadian rhythmicity induced by prolonged light exposure, altered sleep patterns and shift work is associated with the development of obesity and related metabolic disorders, including type 2 diabetes and cardiovascular diseases. White and brown adipose tissue activity shows circadian rhythmicity, with daily variations in the regulation of metabolic processes such as lipolysis, glucose and lipid uptake, and adipokine secretion. The role of the circadian clock in the regulation of energy homeostasis has raised interest in clock‐related strategies to mitigate metabolic disturbances associated with type 2 diabetes, including ‘resynchronizing’ metabolism through diet or targeting a particular time of a day to potentiate the effect of a pharmacological or physiological treatment. Exercise is an effective intervention to prevent insulin resistance and type 2 diabetes. Beyond its effect on skeletal muscle, exercise training also has a profound effect on adipose tissue. Adipose tissue partly mediates the beneficial effect of exercise on glucose and energy homeostasis, via its metabolic and endocrine function. The interaction between zeitgeber time and diet or exercise is likely to influence the metabolic response of adipose tissue and therefore impact the whole‐body phenotype. Understanding the impact of circadian clock systems on human physiology and how this is regulated by exercise in a tissue‐specific manner will yield new insights for the management of metabolic disorders.

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“…150 Human plasma proteomic conducted across 24 hours revealed strong rhythmicity for 30 proteins, mostly associated with tyrosine kinase signalling and extracellular matrix organization. 154 Along with these findings, temporal profiles of serum and skeletal muscle metabolites are strongly affected by the type of nutrients and by meal timing. 151 As mentioned above, lipidomic and metabolomic analyses conducted in human saliva, serum and skeletal muscle around-the-clock, revealed thousands of robustly oscillating metabolites.…”

Section: When the Clock Goes Wrong: Circadian Misalignments In Humamentioning

confidence: 83%

The importance of being rhythmic: Living in harmony with your body clocks

Dibner

2019

Acta Physiologica

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OSCILLATORSThe time-keeping system, dubbed "circadian" from Latin circa diem (about a day), allows light-sensitive beings, including humans, to coordinate their physiology and behaviour to the daily changes in geophysical time (Figure 1). The mammalian network of body clocks is organized in a strictly hierarchical manner. A master oscillator, residing in the paired suprachiasmatic nuclei (SCN) of the hypothalamus ( Figure 1A), synchronizes a myriad of peripheral oscillators situated in each organ ( Figure 1B) on a daily basis. In turn, rhythmicity in the SCN is entrained by external timecues or Zeitgebers (German term for time givers). Daily changes in light intensity, detected by classical photoreceptors and intrinsically light-sensitive retinal ganglion cells expressing AbstractCircadian rhythms have developed in all light-sensitive organisms, including humans, as a fundamental anticipatory mechanism that enables proactive adaptation to environmental changes. The circadian system is organized in a highly hierarchical manner, with clocks operative in most cells of the body ensuring the temporal coordination of physiological processes. Circadian misalignment, stemming from modern life style, draws increasing attention due to its tight association with the development of metabolic, cardiovascular, inflammatory and mental diseases as well as cancer.This review highlights recent findings emphasizing the role of the circadian system in the temporal orchestration of physiology, with a particular focus on implications of circadian misalignment in human pathologies. K E Y W O R D Scircadian clock, circadian misalignment, continuous recording of circadian bioluminescence, human physiology How to cite this article: Dibner C. The importance of being rhythmic: Living in harmony with your body clocks. Acta Physiol. 2020;228:e13281. https ://doi.

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Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism

Cited by 144 publications

References 45 publications

The Circadian Syndrome: is the Metabolic Syndrome and much more!

The Circadian Syndrome: is the Metabolic Syndrome and much more!

Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue

The importance of being rhythmic: Living in harmony with your body clocks

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