Separation of basic drug enantiomers by capillary zone electrophoresis using ovoglycoprotein as a chiral selector

Role of chemical structure in stereoselective recognition of beta‐blockers and H1‐antihistamines by human serum transferrin in capillary zone electrophoresis

“…Besides CDs and a large variety of other chiral selectors (see review in [9]), proteins showing stereoselective recognition have been used for enantiomer separation in CE. Chiral separation of beta-blockers and H 1 -antihistamines was obtained with different proteins, such as ovoglycoprotein [10], ovomucoid [11], BSA [11], HSA [12], and human serum transferrin [13][14][15][16], etc.…”

Enantiomeric Separation of Basic Drugs with Partially Filled Serum Albumin as Chiral Selector in Capillary Electrophoresis

“…At present, proteins used as enantioselectors include bovine serum albumin and human serum albumin (HSA), α-acid glycoprotein, cellulase, ovomucoid, and human serum transferrin. [18][19][20][21][22] Because of the chiral nature, proteins often interact differently with the enantiomers of chiral molecules. 23,24 This is the basis of the chiral recognition of protein and guest.…”

Separation of basic drug enantiomers by capillary electrophoresis using chicken α1‐acid glycoprotein: Insight into chiral recognition mechanism

“…A number of proteins have been investigated as chiral selectors in CE, either as immobilized ligands or as buffer additives [1,2]. Albumins such as bovine serum albumin [3] and human serum albumin [4], a 1 -acid glycoprotein (a 1 -AGP) [5], ovomucoid from chicken egg whites (OMCHI) [6], ovoglycoprotein from chicken egg whites (OGCHI) [7], avidin [8], and riboflavin binding protein (or flavoprotein) [9], enzymes such as cellobiohydrolase I [10], lysozyme [11] and pepsin [12], and other proteins such as ovotransferrin (or conalbumin) [13] have been employed as chiral selectors.…”