Separation of an effective fraction from turmeric against Streptococcus mutans biofilms by the comparison of curcuminoid content and anti-acidogenic activity

Pandit, Santosh; Kim, Hye-Jin; Kim, Jeongeun; Jeon, Jongho

doi:10.1016/j.foodchem.2010.12.005

Cited by 48 publications

(23 citation statements)

References 30 publications

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“…These compounds can be utilized for controlling dental biofilms and subsequent dental caries formation 2 . The effect of curcumin in combination with a subtherapeutic dose of methotrexate was investigated to salvage hepatotoxicity, oxidative stress and producing synergistic anti-arthritic action with methotrexate by Wistar albino rats were induced with arthiritis through subplantar injection of Freund's Complete Adjuvant and pronounced arthritis after 9 days of injection.…”

Section: Biological Activities Of Curcuminoidsmentioning

confidence: 99%

“…Natural products have been used in traditional medicines for thousands of years, and have shown promise as a source of components for the development of new drugs 1, 2. Turmeric ( Curcuma longa Linn ) is a member of the Zingiberaceae family and is cultivated in tropical and subtropical regions around the world and it is originates from India, Southeast Asia and Indonesia 3 .…”

Section: Introductionmentioning

confidence: 99%

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Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Amalraj¹,

Pius

Gopi

et al. 2017

Journal of Traditional and Complementary Medicine

708

413

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In recent years, several drugs have been developed deriving from traditional products and current drug research is actively investigating the possible therapeutic roles of many Ayruvedic and Traditional Indian medicinal therapies. Among those being investigated is Turmeric. Its most important active ingredient is curcuminoids. Curcuminoids are phenolic compounds commonly used as a spice, pigment and additive also utilized as a therapeutic agent used in several foods. Comprehensive research over the last century has revealed several important functions of curcuminoids. Various preclinical cell culture and animals studies suggest that curcuminoids have extensive biological activity as an antioxidant, neuroprotective, antitumor, anti-inflammatory, anti-acidogenic, radioprotective and arthritis. Different clinical trials also suggest a potential therapeutic role for curcuminoids in numerous chronic diseases such as colon cancer, lung cancer, breast cancer, inflammatory bowel diseases. The aim of this review is to summarize the chemistry, analog, metal complex, formulations of curcuminoids and their biological activities.

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Section: Biological Activities Of Curcuminoidsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Amalraj¹,

Pius

Gopi

et al. 2017

Journal of Traditional and Complementary Medicine

708

413

View full text Add to dashboard Cite

show abstract

“…Acid killing and H + permeability assays were performed to evaluate the effect of 1-min fluoride treatment on aciduricity of S. mutans biofilms, as described previously [Belli et al, 1995;Pandit et al, 2011a]. For the acid killing assay, 46-hour-old S. mutans biofilms were treated with fluoride (0, 30, 300, 1,000, or 2,000 ppm F -) for 1 min and incubated in glycine buffer (pH 2.5) for 30 min.…”

Section: Effect On Aciduricitymentioning

confidence: 99%

Effect of 1-Minute Fluoride Treatment on Potential Virulence and Viability of a Cariogenic Biofilm

et al. 2015

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Fluoride is a well-studied and widely used agent for the prevention of dental caries. Although dental caries is strongly related to cariogenic biofilms, the effect of brief fluoride treatment on the virulence properties of biofilms has not been well studied. This study evaluated the effect of a 1-min fluoride treatment on the virulence properties and viability of cariogenic biofilms, using a Streptococcus mutans biofilm model. For this study, 46-hour-old S. mutans biofilms were formed on saliva-coated hydroxyapatite discs and were treated with fluoride (0, 30, 300, 1,000, and 2,000 ppm F^-) for 1 min. Viability and changes in acidogenicity, aciduricity and extracellular polysaccharide (EPS) formation of the biofilms were analyzed using biochemical and microbiological methods (pH drop, H⁺ permeability, acid killing, and bacterial colony-forming unit assays). Laser scanning confocal fluorescence microscopy study was also performed. After the 1-min fluoride treatment, acidogenicity, aciduricity, and EPS formation of 46-hour-old S. mutans biofilms were significantly reduced when treated with concentrations ≥300 ppm F^-. The antivirulence activities of the 1-min fluoride treatment increased in a concentration-dependent pattern. However, the 1-min fluoride treatments did not affect viability, biovolume, and microcolony appearance of biofilm bacteria, even at high concentrations. These results suggest that the brief treatment with fluoride at concentrations ≥300 ppm F^- is an effective measure for controlling cariogenic biofilms.

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“…24 Briefly, the 94 h old biofilms, which had been incubated in 20 mM potassium phosphate buffer (pH 7.2) for 1 h to deplete the endogenous catabolites, were transferred to a salt solution (50 mM KCl plus 1 mM MgCl 2 , pH 7.0). The pH was adjusted to 7.0 with a 0.01 M KOH solution.…”

Section: Glycolytic Ph Drop Assaymentioning

confidence: 99%

Evaluation of Streptococcus mutans biofilms formed on fluoride releasing and non fluoride releasing resin composites

Pandit

Kim

Jeon

2011

Journal of Dentistry

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Separation of an effective fraction from turmeric against Streptococcus mutans biofilms by the comparison of curcuminoid content and anti-acidogenic activity

Cited by 48 publications

References 30 publications

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Effect of 1-Minute Fluoride Treatment on Potential Virulence and Viability of a Cariogenic Biofilm

Evaluation of Streptococcus mutans biofilms formed on fluoride releasing and non fluoride releasing resin composites

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