Separation of aliphatic and aromatic amines by thin-layer chromatography using silica gel plates

Petronio, B.M.; Russo, Mario Vincenzo

doi:10.1007/bf02302464

Cited by 16 publications

(1 citation statement)

References 8 publications

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“…In the study of environmental behavior, it is necessary that simple and sensitive methods be developed to determine aromatic amines in environmental matrices [2 -5]. HPLC [6], GC [7,8], colorimetry [9], TLC [10], and spectrophotometry [11] are often used for the analysis of aromatic amines. Among them, HPLC can offer high sensitivity and selectivity to detect aromatic amines in complicated environmental samples.…”

Section: Introductionmentioning

confidence: 99%

Comparison of continuous‐flow microextraction and static liquid‐phase microextraction for the determination of p‐toluidine in Chlamydomonas reinhardtii

Liu

Chen

Yang

et al. 2007

J of Separation Science

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In this study, two microextraction methods, viz. continuous-flow microextraction (CFME) and static liquid-phase microextraction (s-LPME), were optimized and compared for the determination of p-toluidine in water and Chlamydomonas reinhardtii samples. The calibration curve for p-toluidine was linear in the concentration range of 0.01-5 microg/mL, and the squared regression coefficients (r(2)) for the lines were up to 0.999 for both CFME and s-LPME treatments. Detection limits in CFME and s-LPME were 8.2 ng/mL and 4.9 ng/mL, based on a signal-to-noise (S/N) ratio of 3, respectively. The precision was tested, in five replicates, by analysis of a 100-ng/mL standard solution of p-toluidine and the relative standard deviations were 5.43 and 3.08% for CFME and s-LPME, respectively. The concentration factors were 5.5 and 14.4 for CFME and s-LPME, respectively. s-LPME has a higher extraction efficiency, lower detection limit, and higher concentration factor than that of CFME. Additionally, the s-LPME method is precise and reproducible, and requires only a 3.0-microL microdrop of extraction solvent. Therefore, this procedure is more convenient in use, and viable for qualitative and quantitative analysis of p-toluidine in water and biota samples.

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Section: Introductionmentioning

confidence: 99%

Comparison of continuous‐flow microextraction and static liquid‐phase microextraction for the determination of p‐toluidine in Chlamydomonas reinhardtii

Liu

Chen

Yang

et al. 2007

J of Separation Science

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Aliphatic and Alicyclic Amines

Cavender,

Green

2023

Patty's Toxicology

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Aliphatic and alicyclic amines are a diverse family of chemical substances that touch every aspect of human life. Simple amines are common intermediates used in chemical synthesis and millions of tons are produced annually. Amines are both raw materials needed for bodily function and are prominent waste products. Amines are used in foodstuffs, pharmaceuticals, and agricultural chemicals. In general, it is far more difficult to find a use that does not include amines than to find one that does. Over time, knowledge of the effect of amines on living systems has been increasing, with the largest increases in‐line with the sensitivity of the use. That is, the more of an impact a substance has on the population, the greater the chance a robust database exists. The European Union REACH program (Registration, Evaluation, Authorization of Chemicals) has been responsible for a large influx of data for amine substances that have significant relevance to society but did not have a potential for significant exposure under proper conditions of use. The open use policy from the European Chemicals Agency has allowed REACH data, which was primarily from industrial manufacturers, to be added to this chapter revision, which previously contained academic sources.

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Aliphatic and Alicyclic Amines

Cavender¹

2000

Patty's Toxicology

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Aliphatic and alicyclic amines are nonaromatic amines that have a straight chain, a branched chain, or a cyclic alkyl moiety attached to the nitrogen atom. Aliphatic amines are highly alkaline and tend to be fat soluble. As such, they have the potential to produce severe irritation to skin, eyes, and mucous membranes. Corrosive burns as well as marked allergic sensitization may also occur. Volatile amines, which are characterized by boiling points lower than 100°C, are highly irritating and include methylamine, dimethylamine, trimethylamine, ethylamine, diethylamine, triethylamine, n ‐propylamine, isopropylamine, diisopropylamine, allylamine, n ‐butylamine, isobutylamine, sec ‐butylamine, tert ‐butylamine, and dimethylbutylamine. Workplace practice must consider these properties in developing strategies to protect workers. Toxicity information in humans continues to be limited. Although great strides in understanding the process of carcinogenicity have been made in recent years, controversies regarding potential aliphatic amine carcinogenicity are far from being resolved. Of considerable interest is the possibility of nitrosamine formation, which is both compound specific and pH dependent.

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Separation of aliphatic and aromatic amines by thin-layer chromatography using silica gel plates

Cited by 16 publications

References 8 publications

Comparison of continuous‐flow microextraction and static liquid‐phase microextraction for the determination of p‐toluidine in Chlamydomonas reinhardtii

Comparison of continuous‐flow microextraction and static liquid‐phase microextraction for the determination of p‐toluidine in Chlamydomonas reinhardtii

Aliphatic and Alicyclic Amines

Aliphatic and Alicyclic Amines

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