Separation, identification and quantitation of nitroglycerin and its metabolic or hydrolysis products

Wu, Chien Chin; Sokoloski, Theodore D.; Burkman, Allan M.; Wu, Lei

doi:10.1016/s0021-9673(00)82352-3

Cited by 13 publications

(1 citation statement)

References 22 publications

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“…A Varian 3700 dual column instrument was used, equipped with a 9mCi 63 Ni electron capture detector together with a Chimadzu Chromatopac C-RIA recording data processor. 9 Concentrations of NTG were determined from a standard curve relating drug concentration to the area under NTG chromatogram relative to that of an internal standard (o-iodobenzyl alcohol) of known concentration. Using the internal standard method, the assay precision was ± 6% at NTG concentrations of 50, 100, and 200 ng/ml.…”

Section: Methods_ _ _ _ _ _ _ _ _ _ _ _ _mentioning

confidence: 99%

Extraction of Nitroglycerin by a Membrane Oxygenator

Dasta,

Jacobi,

Sokoloski

et al. 1983

J Extra Corpor Technol

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This study examined the extraction efficiency of a membrane oxygenator for nitroglycerin (NTG). An In-Vitro cardiopulmonary bypass circuit was constructed to mimic clinical conditions. A NTG solution (150 ng/ml) was placed into the circuit via a glass cardiotomy reservoir and circulated at 5 L/min for 60 min. Analysis of NTG samples obtained during the study showed that the oxygenator initially extracted 70% of drug entering the device. A small increase in drug concentration was observed for the first 10 min, followed by a continual decrease. By 60 min only 20% of the original drug concentration remained. We conclude that the membrane oxygenator used during cardiopulmonary bypass is capable of substantially extracting NTG.

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Section: Methods_ _ _ _ _ _ _ _ _ _ _ _ _mentioning

confidence: 99%

Extraction of Nitroglycerin by a Membrane Oxygenator

Dasta,

Jacobi,

Sokoloski

et al. 1983

J Extra Corpor Technol

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Analysis, disposition and pharmacokinetics of nitroglycerin

Curry

Aburawi

1985

Biopharm & Drug Disp

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Influence of Cardiopulmonary Bypass on Nitroglycerin Clearance

Dasta

Weber

et al. 1986

The Journal of Clinical Pharma

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The effect of cardiopulmonary bypass on the clearance of nitroglycerin (NTG) was studied in seven patients scheduled for coronary artery bypass graft surgery. Intravenous NTG was administered through nonadsorbing tubing at a starting dosage of 5-10 micrograms/min and was adjusted as needed. Blood samples were obtained from the radial artery and antecubital vein before bypass and from the arterial outlet of the oxygenator during bypass at least 30 minutes apart during a constant dosage or at least 30 minutes after a dosage change. Serum concentrations were analyzed for NTG by gas chromatography. Venous NTG concentrations were always lower than concurrent arterial concentrations, with an average arteriovenous extraction of 67.2%. Serum concentrations of NTG were generally within the range associated with a therapeutic response in congestive heart failure patients. Consistent with other reports, NTG concentrations varied widely among patients and considerable intrasubject fluctuations in drug concentrations were seen. The mean +/- SD apparent clearance of NTG before bypass of 0.044 +/- 0.02 L/kg/min increased 20% to 0.052 +/- 0.02 L/kg/min during bypass (P = .05). These results suggest that cardiopulmonary bypass increases the clearance of NTG; however, the magnitude appears to be small and only partially explains the reported increased dosage needed during cardiopulmonary bypass.

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Separation, identification and quantitation of nitroglycerin and its metabolic or hydrolysis products

Cited by 13 publications

References 22 publications

Extraction of Nitroglycerin by a Membrane Oxygenator

Extraction of Nitroglycerin by a Membrane Oxygenator

Analysis, disposition and pharmacokinetics of nitroglycerin

Influence of Cardiopulmonary Bypass on Nitroglycerin Clearance

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