Separation and some properties of Aloe vera L. leaf pulp lectins

Akev, Nuriye; Can, Ayşe

doi:10.1002/(sici)1099-1573(199909)13:6<489::aid-ptr499>3.0.co;2-5

Cited by 18 publications

(8 citation statements)

References 17 publications

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“…Lectin purification. Two distinct lectins namely, Aloctin I and Aloctin II, were purified to apparent homogeneity from A. vera leaf pulp aqueous extract by ammonium sulphate fractionation and hydroxylapatite column chromatography as described previously (Akev and Can, 1999). The main lectin, named Aloctin I, was used in this study.…”

Section: Methodsmentioning

confidence: 99%

“…In two studies, lectins purified from A. arborescens Miller were reported to augment antitumour immunity through activation of T-cells (Yoshimoto et al, 1987) and to inhibit mouse methylcholanthrene-induced fibrosarcoma (Imanishi et al, 1981). In the present study, the antitumour effect of the main A. vera lectin (Aloctin I), purified to apparent homogeneity and characterized previously in our laboratory (Akev and Can, 1999), against Ehrlich ascites tumours was investigated in vivo.…”

Section: Introductionmentioning

confidence: 91%

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Effect of Aloe vera leaf pulp extract on Ehrlich ascites tumours in mice

Akev

Turkay²,

Can

et al. 2007

European Journal of Cancer Prevention

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Among the various known therapeutic effects of Aloe vera (L.) Burm. fil., a few recent studies have shown that preparations of the plant leaves can prevent or regress the growth of certain tumours. In this study, undertaken with A. vera leaf pulp extract against Ehrlich ascites tumours in mice, the animals were separated into five groups: I - healthy control, II - tumour control, III - experiment 1 (extract given before tumour inoculation), IV - experiment 2 (extract given with tumour inoculation) and V - experiment 3 (extract given after tumour inoculation). Ehrlich ascites tumours (0.33 ml) were injected subcutaneously into groups II-V. Aloe extract was injected at 55 mg protein/kg, twice a week for 21 days. Tumour size, thymus and spleen weights were measured, as well as leucocyte count, tumour necrosis factor-alpha and sialic acid as tumour markers. The best inhibitory effect on tumour growth was obtained with the extract given prophylactically before tumour implantation (experiment 1), although Aloe extract also regressed tumour sizes when given simultaneously with (experiment 2), or therapeutically after (experiment 3), tumour implantation. Accordingly, serum sialic acid and tumour necrosis factor-alpha levels, chosen as tumour markers, which were raised in the tumour control group, were significantly decreased by the prophylactic administration of the extract. The increase in leucocyte count seen in experiment 1 and 2 groups, along with lymphoid hyperplasia observed in spleen and thymus necroscopy, lead us to think that the tumour preventive effect of Aloe could be due to its immunomodulatory activity. According to our results, A. vera could be proposed as a prophylactic for cancer prevention.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Effect of Aloe vera leaf pulp extract on Ehrlich ascites tumours in mice

Akev

Turkay²,

Can

et al. 2007

European Journal of Cancer Prevention

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“…They are hapten inhibition tests performed in order to investigate the inhibition of lectin-induced hemagglutination and thus find the proper ligand of the lectin. The hemagglutination inhibition tests by various carbohydrates were performed in a manner analogous to the hemagglutination test (Wang et al 1995;Akev and Can 1999). The carbohydrates used were D-maltose, D(+)-raffinose, mellibiose, D-mannose, N-acetyl-Dgalactosamine and chitin.…”

Section: Hemagglutination Inhibition Testsmentioning

confidence: 99%

Comparative Study on the Anticancer Drug Potential of a Lectin Purified from Aloe Vera and Aloe-Emodin

Akev

Çandöken

Erdem‐Kuruca

2020

Asian Pac J Cancer Prev

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“…Yagi et al (1997) reported on the glycoproteins in the "gel" (inner leaf). Aken and Can (1999) gave an account of the presence of lectins aloctin I and II in aloe vera leaf and leaf juice (exudate included). Park and Son (2006) reported on lectins, glycoproteins, and proteinase inhibitors in aloe vera leaves.…”

Section: Proteins Glycoproteins and Amino Acidsmentioning

confidence: 99%

Could We Really Use Aloe Vera Food Supplements to Treat Diabetes?

Habtemariam¹

2017

Int J Diabetes Clin Res

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Separation and some properties of Aloe vera L. leaf pulp lectins

Cited by 18 publications

References 17 publications

Effect of Aloe vera leaf pulp extract on Ehrlich ascites tumours in mice

Effect of Aloe vera leaf pulp extract on Ehrlich ascites tumours in mice

Comparative Study on the Anticancer Drug Potential of a Lectin Purified from Aloe Vera and Aloe-Emodin

Could We Really Use Aloe Vera Food Supplements to Treat Diabetes?

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