Abstract:Related substances, such as process-related substances and degradation products, may affect the efficacy of drugs and cause adverse reactions. Therefore, identifying and controlling them is of the importance. A rapid ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) method has been developed for the separation and characterization of related substances in Candesartan cilexetil tablets. Chromatographic separation was achieved by using ZORBAX Ec… Show more
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