Separation and electrochemical detection of paracetamol and 4-aminophenol in a paper-based microfluidic device

Shiroma, Leandro Y.; Santhiago, Murilo; Gobbi, Ângelo L.; Kubota, Lauro T.

doi:10.1016/j.aca.2012.03.011

Cited by 197 publications

(119 citation statements)

References 33 publications

Supporting

Mentioning

113

Contrasting

Unclassified

Order By: Relevance

“…1.2b). Electrochemical sensors allowed the detection of glucose [94,95], lactate [94,95], uric acid [94], cholesterol [95], tumour markers [101], dopamine [106] and drugs [107]. Other studies described heavy metal sensors for environmental monitoring [94,96,99,100].…”

Section: Electrochemical Sensorsmentioning

confidence: 98%

“…When the sample was introduced to the device, it was wicked up into the sensing zones and the amperometric measurement was initiated via a glucometer. Alternatively, gold can be sputtered on the paper matrix through a shadow mask for the deposition of electrodes [107]. Such electrodes can be characterised by cyclic and square wave voltammetry, and chronoamperometry.…”

Section: Electrochemical Sensorsmentioning

confidence: 99%

See 1 more Smart Citation

Point-of-Care Diagnostics

Yetisen

2014

Holographic Sensors

View full text Add to dashboard Cite

Rapid tests that are low-cost and portable are the first line of defence in healthcare systems. Dipstick and lateral-flow are the two universal assay formats as they are lightweight and compact, and provide qualitative results without external instrumentation. However, existing formats have limitations in the quantification of analyte concentrations. Hence, the demand for sample preparation, improved sensitivity and user-interface has challenged the commercial products. Recently, capabilities, sensors and readout devices were expanded to multiplexable assays platforms, which might transcend the capabilities of existing design format of diagnostic tests. This chapter outlines the evolution of diagnostic devices and current trends in the development of qualitative and quantitative sensing devices for applications in healthcare, veterinary medicine, environmental monitoring and food safety. The chapter also discusses design parameters for diagnostics, their functionalisation to increase the capabilities and the performance, emerging sensing platforms and readout technologies. The factors which limit the emerging rapid diagnostics to become commercial products are also discussed.The life expectancy has grown worldwide, which also increased the healthcare spending [1, 2]. For example, 720 million people will be aged 65 or older by 2020. Currently four in five people over the age of 75 take at least one prescribed medicine, and this trend is set to increase [3]. For some of the medications, large pharma find it the hard to recover R&D costs while the pressure from the regulatory agencies also increased for the use of new drugs as the first line of defence based on efficacy and cost. Hence, the global healthcare trends and ever increasing pressure from regulatory agencies put a strong case for the development of diagnostics for healthcare monitoring as well as the evaluation of drug efficacies in clinical trials. All these considerations parallels governments' and insurance companies' interests in obtaining the best performance possible and treatment benefits they support. These trends are behind the driving force for the development of diagnostics that can reduce the healthcare costs by developing effective drugs and identifying diseases and conditions at an early stage.The major stumbling block in monitoring and controlling diseases/contaminations remains delivering simple, low-cost and robust diagnostic tests [4,5]. In the developing world, the basic healthcare infrastructure and trained healthcare personnel are

show abstract

Section: Electrochemical Sensorsmentioning

confidence: 98%

Section: Electrochemical Sensorsmentioning

confidence: 99%

Point-of-Care Diagnostics

Yetisen

2014

Holographic Sensors

View full text Add to dashboard Cite

show abstract

“…The signal/noise ratio, however, can be increased upon reducing the scan rate of the voltage. 5 [12] paracetamol, 4-aminophenol Amperometry Knoll et al [13] K + , Na + Potentiometry Novell et al [14] NH 4 + , K + , pH Potentiometry …”

Section: S6 Repads For Multiplexed Voltammetrymentioning

confidence: 99%

Paper-based electroanalytical devices with an integrated, stable reference electrode

et al. 2013

View full text Add to dashboard Cite

“…Using stencilprinting for example, microelectrodes with a chemical mediator have been fabricated for ePAD detection [17]. Metallic ink and sputter-coated electrodes have also been used, albeit to a lesser extent [10,18,19].…”

Section: Introductionmentioning

confidence: 99%