Separation and concentration of L-phenylalanine using a supported liquid membrane

“…The downstream processes of fermentation include cell removal, ion-exchange, evaporation, and crystallization. 1 The ion-exchange processes, however, generate a lot of highly concentrated salt wastewater during the regeneration of ionexchange resin. With the growing concern over environmental issues, such wastewater will increase the treatment cost and weaken the competitiveness of the process.…”

Section: Introductionmentioning

confidence: 99%

Structural effects of ion‐exchange membrane on the separation of L‐phenylalanine (L‐Phe) from fermentation broth using electrodialysis

Choi

Moon

2002

J of Chemical Tech & Biotech

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The effects of membrane structure on the separation of L-phenylalanine (L-Phe) by electrodialysis from a fermentation broth and on the fouling tendency were investigated in this study. Two anion-exchange membranes (Neosepta AFX and AM-1, Tokuyama, Japan) were selected and characterized using the chronopotentiometry method. For a fresh membrane, AFX showed a lower electrical resistance and a lower permselectivity than AM-1. After being fouled with humic acid, however, the electrical resistance of AFX was higher than that of AM-1. The L-Phe selectivities for both membranes were lower than those of the fresh membranes. The result may be attributed to the structural difference between AFX and AM-1 membranes. AFX has a lower repulsion force against the co-ion and could be more strongly affected by the foulants than AM-1 because AFX has a more porous structure than AM-1. Experiments on the separation of L-Phe from the fermentation broth were carried out using two different stack con®gurations, ie desalting electrodialysis and water-splitting electrodialysis. It was observed that the recovery ef®ciency of L-Phe through electrodialysis for 100 min reached 95% for AFX and 85% for AM-1. In the desalting con®guration of electrodialysis, the solution pH must be adjusted to alkaline conditions to recover the L-Phe through the anion-exchange membrane. On the contrary, it was possible to recover the L-Phe without adjustment of the solution pH in the water-splitting electrodialysis because OH À generated from the bipolar membrane converted neutral L-Phe into an anion.

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“…Because of the above‐mentioned advantages many separation processes have been studied using hollow‐fibre membrane contactors that have the potential to provide good performance and long‐term stability. The studies include recovery of metals,20, 21 the extraction of organic solutes from dilute solutions,22–24 and extraction of antibiotics 13, 25–28. The contactors have a shell‐and‐tube configuration and allow the flow of two solutions along the shell and fibre sides.…”

Section: Introductionmentioning

confidence: 99%

Membrane extraction of a new antibiotic (Shengjimycin): equilibrium and mass transfer analysis

Hossain¹,

Kam²,

Jiang³

et al. 2011

J of Chemical Tech & Biotech

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BACKGROUND: During the last two decades, separations based on liquid membrane technology have been demonstrated to be a potentially attractive process for a large number of industrial separations. The advantages of this technology over the current separation processes allowed its commercialization in the area of chemical/environmental applications (for the removal of toxic metals). Efforts are being devoted to biotechnological processes where membrane extraction has an added advantage of improving the productivity by removing inhibitory product during its production cycle. In this article the applicability of a membrane extraction technique based on hollow-fibre membrane modules is investigated to extract a new antibiotic, Shengjimycin (SJM). SJM is produced in a multicomponent fermentation broth, from which the main components required to be separated selectively.

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Separation and concentration of L-phenylalanine using a supported liquid membrane

Cited by 4 publications

References 13 publications

Gas permeation behavior of CTA polymer inclusion membrane (PIM) containing an acidic carrier for metal recovery (DEHPA)

Gas permeation behavior of CTA polymer inclusion membrane (PIM) containing an acidic carrier for metal recovery (DEHPA)

Structural effects of ion‐exchange membrane on the separation of L‐phenylalanine (L‐Phe) from fermentation broth using electrodialysis

Membrane extraction of a new antibiotic (Shengjimycin): equilibrium and mass transfer analysis

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